SF3B4 Blocking Peptide

Name: SF3B4 Blocking Peptide; MyBioSource
Brand: MyBioSource
SKU: MBS3230320
Price: 195 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3230320

This is a synthetic peptide designed for use in combination with anti-SF3B4 antibody madeTarget Description: SF3B4 is one of four subunits of the splicing factor 3B. The protein cross-links to a region in the pre-mRNA immediately upstream of the branchpoint… More details

$195 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SF3B4, Blocking Peptide

Full Product Name

SF3B4 Peptide

Product Gene Name

SF3B4 blocking peptide

Product Synonym Gene Name

Hsh49; SAP49; SF3b49

Form/Format

Lyophilized powder

Preparation and Storage

Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20 degree C. Avoid repeat freeze-thaw cycles.

Antibody/Peptide Pairs

SF3B4 peptide (MBS3230320) is used for blocking the activity of SF3B4 antibody (MBS3205355)

Molecular Weight

47kDa

OMIM

154400

Product Categories/Family for SF3B4 blocking peptide

Peptide

Applications Tested/Suitable for SF3B4 blocking peptide

Immunohistochemistry (IHC), Western Blot (WB)

Other Notes

Small volumes of SF3B4 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SF3B4 purchase

MBS3230320 is a blocking peptide targeting SF3B4. Also known as SF3B4 Peptide.

Additional Details

NCBI/Uniprot data below describe general gene information for SF3B4. It may not necessarily be applicable to this product.

NCBI GI #

5032069

NCBI GeneID

10262

NCBI Accession #

NP_005841

UniProt Primary Accession #

Q15427

UniProt Related Accession #

Q15427

GenBank Nucleotide #

NM_005850

NCBI Official Full Name

splicing factor 3B subunit 4

NCBI Official Synonym Full Names

splicing factor 3b subunit 4

NCBI Official Symbol

SF3B4

NCBI Official Synonym Symbols

AFD1; Hsh49; SAP49; SF3b49

UniProt Protein Name

Splicing factor 3B subunit 4

UniProt Synonym Protein Names

Pre-mRNA-splicing factor SF3b 49 kDa subunit; SF3b50; Spliceosome-associated protein 49

Protein Family

Splicing factor

UniProt Gene Name

SF3B4

UniProt Synonym Gene Names

SAP49; SAP 49

UniProt Entry Name

SF3B4_HUMAN

NCBI Protein Information

splicing factor 3B subunit 4

NCBI Summary for SF3B4

This gene encodes one of four subunits of the splicing factor 3B. The protein encoded by this gene cross-links to a region in the pre-mRNA immediately upstream of the branchpoint sequence in pre-mRNA in the prespliceosomal complex A. It also may be involved in the assembly of the B, C and E spliceosomal complexes. In addition to RNA-binding activity, this protein interacts directly and highly specifically with subunit 2 of the splicing factor 3B. This protein contains two N-terminal RNA-recognition motifs (RRMs), consistent with the observation that it binds directly to pre-mRNA. [provided by RefSeq, Jul 2008]

UniProt Comments for SF3B4

SF3B4: subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. SF3B4 has been found in complex 'B' and 'C' as well. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron.

Protein type: RNA-binding; Spliceosome; RNA splicing

Chromosomal Location of Human Ortholog: 1q21.2

Cellular Component: nucleoplasm; spliceosome; U12-dependent spliceosome

Molecular Function: protein binding; nucleotide binding

Biological Process: RNA splicing, via transesterification reactions; nuclear mRNA splicing, via spliceosome; positive regulation of nuclear mRNA splicing, via spliceosome; RNA splicing; gene expression; mRNA processing

Disease: Acrofacial Dysostosis 1, Nager Type

Research Articles on SF3B4

1. SF3B4 indicates early-stage hepatocellular carcinoma in precancerous lesions, and also functions as an early-stage driver in the development of liver cancer.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with SF3B4 blocking peptide

Reference Product	PubMed Publications
SF3B2 blocking peptide	>8 publications with SF3B4 and SF3B2
BMPR1A blocking peptide	>2 publications with SF3B4 and BMPR1A

Pathways associated with SF3B4 blocking peptide

Products by Pathway	Pathway Diagram
Gene Expression Pathway antibodies	Gene Expression Pathway Diagram
Processing Of Capped Intron-Containing Pre-mRNA Pathway antibodies	Processing Of Capped Intron-Containing Pre-mRNA Pathway Diagram
Spliceosome Pathway antibodies	Spliceosome Pathway Diagram
Spliceosome Pathway antibodies	Spliceosome Pathway Diagram
Spliceosome, U2-snRNP Pathway antibodies	Spliceosome, U2-snRNP Pathway Diagram
MRNA Splicing Pathway antibodies	MRNA Splicing Pathway Diagram
MRNA Splicing - Major Pathway antibodies	MRNA Splicing - Major Pathway Diagram
MRNA Splicing - Minor Pathway antibodies	MRNA Splicing - Minor Pathway Diagram
MRNA Processing Pathway antibodies	MRNA Processing Pathway Diagram

Diseases associated with SF3B4 blocking peptide

Disease Name	Pubmed Publications
Neoplasms Antibodies	>1 publications with SF3B4 and Neoplasms
Neoplasms, Experimental Antibodies	>1 publications with SF3B4 and Neoplasms, Experimental
Congenital Abnormalities Antibodies	>1 publications with SF3B4 and Congenital Abnormalities

Organs/Tissues associated with SF3B4 blocking peptide

Organ/Tissue Name	Pubmed Publications
Bone Antibodies	>2 publications with SF3B4 and Bone
Heart Antibodies	>1 publications with SF3B4 and Heart
Blood Antibodies	>1 publications with SF3B4 and Blood
Embryonic Tissue Antibodies	>1 publications with SF3B4 and Embryonic Tissue
Brain Antibodies	>1 publications with SF3B4 and Brain