Mouse Slc5a8 Blocking Peptide (C-Term) Blocking Peptide

Name: Mouse Slc5a8 Blocking Peptide (C-Term) Blocking Peptide; MyBioSource
Brand: MyBioSource
SKU: MBS9228637
Price: 455 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9228637

Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate),… More details

$455 / 0.5 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Slc5a8, Blocking Peptide

Full Product Name

Mouse Slc5a8 Blocking Peptide (C-term)

Product Gene Name

Slc5a8 blocking peptide

Product Synonym Names

Sodium-coupled monocarboxylate transporter 1; Electrogenic sodium monocarboxylate cotransporter; Solute carrier family 5 member 8; Slc5a8

Form/Format

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.

Specificity

The synthetic peptide sequence is selected from aa 563-574 of MOUSE Slc5a8

Preparation and Storage

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Antibody/Peptide Pairs

Slc5a8 peptide (MBS9228637) is used for blocking the activity of Slc5a8 antibody (MBS9213641)

Molecular Weight

66,766 Da

Cellular Location

Membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein Note: Restricted to the apical cell membrane of enterocytes

Tissue Location

Expressed in brain, colon, kidney and in the ileum and jejunum of small intestine. In the kidney, expression occurred in the proximal tubule and the loop of Henle, being restricted to tubular epithelial cells in both the cortex and the medulla. In the colon, predominantly expressed in the distal half of the large bowel and in the most terminal ileum. Localized selectively in the luminal surface of crypts in the large intestine and to the brush border in the middle parts of crypts in the cecum. In the brain, expression was seen throughout, exclusively in neurons, including the cortex, hippocampus, cerebellum and pituitary gland (at protein level). Expression is reduced in oligodendrogliomas.

Other Notes

Small volumes of Slc5a8 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Slc5a8 purchase

MBS9228637 is a blocking peptide targeting Slc5a8. Also known as Mouse Slc5a8 Blocking Peptide (C-term).

Additional Details

NCBI/Uniprot data below describe general gene information for Slc5a8. It may not necessarily be applicable to this product.

NCBI GI #

110347555

NCBI GeneID

216225

NCBI Accession #

NP_663398.2

UniProt Primary Accession #

Q8BYF6

UniProt Secondary Accession #

Q8VD01

UniProt Related Accession #

Q8BYF6

GenBank Nucleotide #

NM_145423.2

NCBI Official Full Name

sodium-coupled monocarboxylate transporter 1

NCBI Official Synonym Full Names

solute carrier family 5 (iodide transporter), member 8

NCBI Official Symbol

Slc5a8

NCBI Official Synonym Symbols

Ait; SMCT

UniProt Protein Name

Sodium-coupled monocarboxylate transporter 1

UniProt Synonym Protein Names

Electrogenic sodium monocarboxylate cotransporter; Solute carrier family 5 member 8

Protein Family

Sodium-coupled monocarboxylate transporter

UniProt Gene Name

Slc5a8

UniProt Entry Name

SC5A8_MOUSE

NCBI Protein Information

sodium-coupled monocarboxylate transporter 1

UniProt Comments for Slc5a8

SLC5A8: Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), lactate, mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D- hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for the absorption of D- lactate and monocarboxylate drugs from the intestinal tract. Acts as a tumor suppressor, suppressing colony formation in colon cancer, prostate cancer and glioma cell lines. May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient and hence contribute to the maintenance of the energy status and function of neurons. Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.

Protein type: Membrane protein, multi-pass; Transporter, SLC family; Membrane protein, integral; Apoptosis; Tumor suppressor; Transporter

Cellular Component: integral to plasma membrane

Molecular Function: symporter activity

Research Articles on Slc5a8

1. Slc5a8 is an obligatory link between dietary fibre and mucosal immune system via the bacterial metabolite butyrate and that this transporter is a conditional tumour suppressor in colon linked to dietary fibre content.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with Slc5a8 blocking peptide

Products by Pathway	Pathway Diagram
Organic Anion Transporters Pathway antibodies	Organic Anion Transporters Pathway Diagram
SLC-mediated Transmembrane Transport Pathway antibodies	SLC-mediated Transmembrane Transport Pathway Diagram
Transmembrane Transport Of Small Molecules Pathway antibodies	Transmembrane Transport Of Small Molecules Pathway Diagram
Transport Of Inorganic Cations/anions And Amino Acids/oligopeptides Pathway antibodies	Transport Of Inorganic Cations/anions And Amino Acids/oligopeptides Pathway Diagram

Diseases associated with Slc5a8 blocking peptide

Disease Name	Pubmed Publications
Colonic Neoplasms Antibodies	>12 publications with Slc5a8 and Colonic Neoplasms
Inflammation Antibodies	>8 publications with Slc5a8 and Inflammation
Adenocarcinoma Antibodies	>4 publications with Slc5a8 and Adenocarcinoma
Cell Transformation, Neoplastic Antibodies	>4 publications with Slc5a8 and Cell Transformation, Neoplastic
Necrosis Antibodies	>4 publications with Slc5a8 and Necrosis
Fatty Liver Antibodies	>3 publications with Slc5a8 and Fatty Liver
Hyperuricemia Antibodies	>2 publications with Slc5a8 and Hyperuricemia
Prostatic Neoplasms Antibodies	>2 publications with Slc5a8 and Prostatic Neoplasms
Neoplasm Metastasis Antibodies	>1 publications with Slc5a8 and Neoplasm Metastasis
Kidney Diseases Antibodies	>1 publications with Slc5a8 and Kidney Diseases

Organs/Tissues associated with Slc5a8 blocking peptide

Organ/Tissue Name	Pubmed Publications
Intestine Antibodies	>26 publications with Slc5a8 and Intestine
Kidney Antibodies	>20 publications with Slc5a8 and Kidney
Eye Antibodies	>10 publications with Slc5a8 and Eye
Lung Antibodies	>5 publications with Slc5a8 and Lung
Salivary Gland Antibodies	>2 publications with Slc5a8 and Salivary Gland
Embryonic Tissue Antibodies	>1 publications with Slc5a8 and Embryonic Tissue
Mammary Gland Antibodies	>1 publications with Slc5a8 and Mammary Gland