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SMURF1 Blocking Peptide – The purity is >90%,tested by HPLC and MS. Purity

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9616613

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the… More details

$460 / 1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
SMURF1, Blocking Peptide
Full Product Name
SMURF1 Blocking Peptide
Product Gene Name
SMURF1 blocking peptide
Product Synonym Gene Name
SMURF1
Product Synonym Names
E3 ubiquitin-protein ligase SMURF1; hSMURF1; KIAA1625; Smad specific E3 ubiquitin ligase 1; SMAD specific E3 ubiquitin protein ligase 1; Smad ubiquitination regulatory factor 1; SMAD-specific E3 ubiquitin-protein ligase 1; SMUF1_HUMAN; SMURF 1; smurf1
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.
Purity/Purification
The purity is >90%,tested by HPLC and MS.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Antibody/Peptide Pairs
SMURF1 peptide (MBS9616613) is used for blocking the activity of SMURF1 antibody (MBS9613331)
Molecular Weight
83,440 Da
OMIM
605568
Supply Chain Verification
Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.
Notes
For phospho antibody, we provide phospho peptide (0.5mg) and non-phospho peptide (0.5mg)
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for SMURF1 blocking peptide
Blocking/Control

Other Notes

Small volumes of SMURF1 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SMURF1 purchase

MBS9616613 is a blocking peptide targeting SMURF1.

Additional Details

NCBI/Uniprot data below describe general gene information for SMURF1. It may not necessarily be applicable to this product.

NCBI GI #
315434204
NCBI GeneID
57154
NCBI Accession #
NP_001186776.1
UniProt Primary Accession #
Q9HCE7
UniProt Secondary Accession #
O75853; Q547Q3; Q9UJT8; A4D279; B7ZMB6; B9EGV3
UniProt Related Accession #
Q9HCE7
GenBank Nucleotide #
NM_001199847.1
NCBI Official Full Name
E3 ubiquitin-protein ligase SMURF1 isoform 3
NCBI Official Synonym Full Names
SMAD specific E3 ubiquitin protein ligase 1
NCBI Official Symbol
SMURF1
UniProt Protein Name
E3 ubiquitin-protein ligase SMURF1
UniProt Synonym Protein Names
SMAD ubiquitination regulatory factor 1; SMAD-specific E3 ubiquitin-protein ligase 1
Protein Family
E3 ubiquitin-protein ligase
UniProt Gene Name
SMURF1
UniProt Synonym Gene Names
KIAA1625; hSMURF1
UniProt Entry Name
SMUF1_HUMAN
NCBI Protein Information
E3 ubiquitin-protein ligase SMURF1

NCBI Summary for SMURF1

This gene encodes a ubiquitin ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. This protein plays a key roll in the regulation of cell motility, cell signalling, and cell polarity. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Dec 2010]
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UniProt Comments for SMURF1

SMURF1: E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. Interacts with TRAF4. Interacts (via HECT domain) with FBXL15 (via LRR repeats). Interacts with SMAD7 and TGFBR1; SMAD7 recruits SMURF1 to TGFBR1 and regulates TGF-beta receptor degradation. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 6.3.2.19; Ubiquitin conjugating system; EC 6.3.2.-; Ligase; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 7q22.1

Cellular Component: axon; cell soma; cytoplasm; cytosol; mitochondrion; nucleoplasm; nucleus; plasma membrane

Molecular Function: activin binding; ligase activity; phospholipid binding; protein binding; ubiquitin-protein ligase activity

Biological Process: BMP signaling pathway; cell differentiation; ectoderm development; negative regulation of BMP signaling pathway; negative regulation of ossification; negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of defense response to virus by host; proteasomal ubiquitin-dependent protein catabolic process; protein export from nucleus; protein polyubiquitination; protein ubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process; receptor catabolic process; transforming growth factor beta receptor signaling pathway; ubiquitin-dependent SMAD protein catabolic process; Wnt receptor signaling pathway, planar cell polarity pathway
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Research Articles on SMURF1

1. a model that CD166 regulates MCAM through a signaling flow from activation of PI3K/AKT and c-Raf/MEK/ERK signaling to the inhibition of potential MCAM ubiquitin E3 ligases, betaTrCP and Smurf1.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with SMURF1 blocking peptide

 Reference Product  PubMed Publications
 SMAD1 blocking peptide  >42 publications with SMURF1 and SMAD1
 RHOA blocking peptide  >40 publications with SMURF1 and RHOA
 SMAD7 blocking peptide  >34 publications with SMURF1 and SMAD7
 SMAD2 blocking peptide  >24 publications with SMURF1 and SMAD2
 SMAD4 blocking peptide  >18 publications with SMURF1 and SMAD4
 SMAD5 blocking peptide  >18 publications with SMURF1 and SMAD5
 SMAD3 blocking peptide  >17 publications with SMURF1 and SMAD3
 SMAD6 blocking peptide  >17 publications with SMURF1 and SMAD6

Pathways associated with SMURF1 blocking peptide

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Processing: Ubiquitination & Proteasome Degradation Pathway antibodies  Antigen Processing: Ubiquitination & Proteasome Degradation Pathway Diagram
 Asymmetric Localization Of PCP Proteins Pathway antibodies  Asymmetric Localization Of PCP Proteins Pathway Diagram
 BMP Receptor Signaling Pathway antibodies  BMP Receptor Signaling Pathway Diagram
 BMP Signalling And Regulation Pathway antibodies  BMP Signalling And Regulation Pathway Diagram
 Beta-catenin Independent WNT Signaling Pathway antibodies  Beta-catenin Independent WNT Signaling Pathway Diagram
 Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies  Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
 Downregulation Of TGF-beta Receptor Signaling Pathway antibodies  Downregulation Of TGF-beta Receptor Signaling Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram

Diseases associated with SMURF1 blocking peptide

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >13 publications with SMURF1 and Necrosis
 Inflammation Antibodies  >9 publications with SMURF1 and Inflammation
 Fibrosis Antibodies  >8 publications with SMURF1 and Fibrosis
 Breast Neoplasms Antibodies  >8 publications with SMURF1 and Breast Neoplasms
 Liver Diseases Antibodies  >7 publications with SMURF1 and Liver Diseases
 Liver Neoplasms Antibodies  >7 publications with SMURF1 and Liver Neoplasms
 Neoplasm Metastasis Antibodies  >5 publications with SMURF1 and Neoplasm Metastasis
 Kidney Diseases Antibodies  >5 publications with SMURF1 and Kidney Diseases
 Cardiovascular Diseases Antibodies  >5 publications with SMURF1 and Cardiovascular Diseases
 Adenocarcinoma Antibodies  >5 publications with SMURF1 and Adenocarcinoma

Organs/Tissues associated with SMURF1 blocking peptide

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >89 publications with SMURF1 and Bone
 Muscle Antibodies  >13 publications with SMURF1 and Muscle
 Connective Tissue Antibodies  >12 publications with SMURF1 and Connective Tissue
 Embryonic Tissue Antibodies  >11 publications with SMURF1 and Embryonic Tissue
 Kidney Antibodies  >10 publications with SMURF1 and Kidney
 Heart Antibodies  >9 publications with SMURF1 and Heart
 Liver Antibodies  >9 publications with SMURF1 and Liver
 Bone Marrow Antibodies  >8 publications with SMURF1 and Bone Marrow
 Brain Antibodies  >8 publications with SMURF1 and Brain
 Blood Antibodies  >6 publications with SMURF1 and Blood
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