SNF8 Antibody (N-Term) Blocking Peptide

The protein encoded by this gene is a component of the endosomal sorting complex required for transport II (ESCRT-II), which regulates the movement of ubiquitinylated transmembrane proteins to the lysosome for degradation. This complex also interacts with the RNA polymerase II elongation factor (ELL) to overcome the repressive effects of ELL on RNA polymerase II activity. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

SNF8: Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL. Required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization. It is also required for the degradation of CXCR4. Belongs to the SNF8 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor

Chromosomal Location of Human Ortholog: 17q21.32

Cellular Component: cytoplasm; cytosol; endosome membrane; late endosome membrane; membrane; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane; recycling endosome; transcription factor complex

Molecular Function: channel regulator activity; protein binding; protein C-terminus binding; protein homodimerization activity; protein N-terminus binding; transcription factor binding

Biological Process: autophagy; early endosome to late endosome transport; endocytic recycling; endosome transport; positive regulation of protein catabolic process; protein targeting to vacuole during ubiquitin-dependent protein catabolic process via the MVB pathway; regulation of MAP kinase activity; regulation of protein catabolic process; regulation of transcription from RNA polymerase II promoter