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SPPL2A Blocking Peptide

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9633269

MBS9633269 is a blocking peptide targeting SPPL2A. More details

$460 / 1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
SPPL2A, Blocking Peptide
Full Product Name
SPPL2A Blocking Peptide
Product Gene Name
SPPL2A blocking peptide
Product Synonym Names
EC 3.4.99; IMP3; Intramembrane protease 3; Presenilin like protein 2; PSL2; Signal peptide peptidase like 2A; SPP like 2A protein
Antibody/Peptide Pairs
SPPL2A peptide (MBS9633269) is used for blocking the activity of SPPL2A antibody (MBS9630886)
Molecular Weight
58,143 Da
Chromosome Location
Chromosome: 15; NC_000015.9 (50999730..51057910, complement). Location: 15q21.2
OMIM
608238
Supply Chain Verification
Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of SPPL2A blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SPPL2A. It may not necessarily be applicable to this product.

NCBI GI #
21314755
NCBI GeneID
84888
NCBI Accession #
NP_116191.2
UniProt Primary Accession #
Q8TCT8
UniProt Secondary Accession #
Q8TAW1; Q96SZ8; B2RDS0
UniProt Related Accession #
Q8TCT8
GenBank Nucleotide #
NM_032802.3
NCBI Official Full Name
signal peptide peptidase-like 2A
NCBI Official Symbol
SPPL2A
NCBI Official Synonym Symbols
IMP3; PSL2
UniProt Protein Name
Signal peptide peptidase-like 2A
UniProt Synonym Protein Names
Intramembrane protease 3; IMP-3; Presenilin-like protein 2
Protein Family
Signal peptide peptidase
UniProt Gene Name
SPPL2A
UniProt Synonym Gene Names
IMP3; PSL2
UniProt Entry Name
PSL2_HUMAN
NCBI Protein Information
signal peptide peptidase-like 2A; IMP-3; SPP-like 2A; OTTHUMP00000162418; intramembrane protease 3; presenilin-like protein 2; intramembrane cleaving protease

NCBI Summary for SPPL2A

This gene is a member of the signal peptide peptidase-like protease (SPPL) family and encodes an endosomal membrane protein with a protease associated (PA) domain. This protein plays a role in innate and adaptive immunity. A pseudogene of this gene also lies on chromosome 15. [provided by RefSeq]

UniProt Comments for SPPL2A

SPPL2A: Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in FASLG, ITM2B and TNF processing. Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus. Also responsible for the intramembrane cleavage of Fas antigen ligand FASLG, which promotes the release of the intracellular FasL domain (FasL ICD). May play a role in the regulation of innate and adaptive immunity. Belongs to the peptidase A22B family.

Protein type: EC 3.4.23.-; Membrane protein, multi-pass; Cancer Testis Antigen (CTA); Protease; Membrane protein, integral

Chromosomal Location of Human Ortholog: 15q21.2

Cellular Component: lysosomal membrane; late endosome membrane; plasma membrane

Molecular Function: protein binding; protein homodimerization activity; aspartic-type endopeptidase activity

Biological Process: regulation of immune response; membrane protein intracellular domain proteolysis; membrane protein ectodomain proteolysis
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Research Articles on SPPL2A

1. SPPL2a and SPPL2b mediate the intramembrane cleavage, whereas neither SPP nor SPPL3 is capable of processing the Bri2 N-terminal fragment.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with SPPL2A blocking peptide

 Disease Name  Pubmed Publications
 Arthritis, Rheumatoid Antibodies  >1 publications with SPPL2A and Arthritis, Rheumatoid

Organs/Tissues associated with SPPL2A blocking peptide

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1 publications with SPPL2A and Blood
 Kidney Antibodies  >1 publications with SPPL2A and Kidney
 Skin Antibodies  >1 publications with SPPL2A and Skin
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