Suz12 Blocking Peptide (Center) Blocking Peptide

This gene encodes a core component of the polycomb repressive complex 2 (PRC2) that also includes, at least, embryonic ectoderm development protein (EED) and enhancer of zeste homolog 1 or 2 (EZH1 or EZH2). Through the methyltransferase activity of EZH1 or EZH2, the PRC2 complex methylates Lys9 and Lys27 of histone 3 and Lys26 of histone 1, leading to recruitment of the PRC1 complex, histone 2A ubiquitylation and transcriptional repression of the target genes. This gene product is essential for the activity and integrity of the PRC2 complex, and is required for X chromosome inactivation, stem cell maintenance and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]

SUZ12: a zinc finger protein. A breakpoint translocation of the cognate gene with JAZF1 has been reported in endometrial stromal sarcoma.

Protein type: Oncoprotein; C2H2-type zinc finger protein; Transcription factor

Cellular Component: ESC/E(Z) complex; nucleolus; nucleus; sex chromatin

Molecular Function: chromatin binding; chromatin DNA binding; histone methyltransferase activity; methylated histone residue binding; protein binding; RNA binding; sequence-specific DNA binding

Biological Process: histone methylation; histone ubiquitination; negative regulation of cell differentiation; negative regulation of chemokine production; negative regulation of epithelial cell proliferation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of tyrosine phosphorylation of Stat3 protein; positive regulation of cell proliferation