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TEC Antibody (Center) Blocking Peptide

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9227199

Non-receptor tyrosine kinase that contributes to signaling from many receptors and participates as a signal transducer in multiple downstream pathways, including regulation of the actin cytoskeleton. Plays a redundant role to ITK in regulation of the adaptive… More details

$455 / 0.5 mg +1 FREE 8GB USB
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
TEC, Blocking Peptide
Full Product Name
TEC Antibody (Center) Blocking Peptide
Product Gene Name
TEC blocking peptide
Product Synonym Gene Name
PSCTK4
Product Synonym Names
Tyrosine-protein kinase Tec; TEC; PSCTK4
Form/Format
The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
Specificity
The synthetic peptide sequence used to generate the antibody was selected from the Center region of human TEC. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Antibody/Peptide Pairs
TEC peptide (MBS9227199) is used for blocking the activity of TEC antibody (MBS9215281)
Molecular Weight
73,581 Da
OMIM
600583
Cellular Location
Cytoplasm. Cell membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Note: Following B-cell or T-cell receptors activation by antigen, translocates to the plasma membrane through its PH domain. Thrombin and integrin engagement induces translocation of TEC to the cytoskeleton during platelet activation. In cardiac myocytes, assumes a diffuse intracellular localization under basal conditions but is recruited to striated structures upon various stimuli, including ATP (By similarity).
Tissue Location
Expressed in a wide range of cells, including hematopoietic cell lines like myeloid, B-, and T-cell lineages

Other Notes

Small volumes of TEC blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TEC purchase

MBS9227199 is a blocking peptide targeting TEC. Also known as TEC Antibody (Center) Blocking Peptide.

Additional Details

NCBI/Uniprot data below describe general gene information for TEC. It may not necessarily be applicable to this product.

NCBI GI #
158518392
NCBI GeneID
7006
NCBI Accession #
P42680.2
UniProt Primary Accession #
P42680
UniProt Secondary Accession #
Q3MIS5; B7ZKZ6
UniProt Related Accession #
P42680
NCBI Official Full Name
Tyrosine-protein kinase Tec
NCBI Official Synonym Full Names
tec protein tyrosine kinase
NCBI Official Symbol
TEC
NCBI Official Synonym Symbols
PSCTK4
UniProt Protein Name
Tyrosine-protein kinase Tec
Protein Family
Protein
UniProt Gene Name
TEC
UniProt Synonym Gene Names
PSCTK4
UniProt Entry Name
TEC_HUMAN
NCBI Protein Information
tyrosine-protein kinase Tec

NCBI Summary for TEC

The protein encoded by this gene belongs to the Tec family of non-receptor protein-tyrosine kinases containing a pleckstrin homology domain. Tec family kinases are involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and integrin molecules. They are also key players in the regulation of the immune functions. Tec kinase is an integral component of T cell signaling and has a distinct role in T cell activation. This gene may be associated with myelodysplastic syndrome. [provided by RefSeq, Jul 2008]
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UniProt Comments for TEC

TEC: a non-receptor protein-tyrosine kinases of the Tec family. Containing a pleckstrin homology domain. Involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and integrin molecules. May be an important signal transducer for cell division and/or for differentiation in the liver system.

Protein type: Protein kinase, tyrosine (non-receptor); EC 2.7.10.2; Protein kinase, TK; Kinase, protein; TK group; Tec family

Chromosomal Location of Human Ortholog: 4p12

Cellular Component: cytoskeleton; cytosol; extrinsic to internal side of plasma membrane

Molecular Function: non-membrane spanning protein tyrosine kinase activity; protein binding; receptor binding

Biological Process: B cell receptor signaling pathway; cell differentiation; innate immune response; integrin-mediated signaling pathway; peptidyl-tyrosine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; protein amino acid phosphorylation; regulation of cell proliferation; tissue regeneration; transmembrane receptor protein tyrosine kinase signaling pathway
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Research Articles on TEC

1. These results provide the first evidence that Nef interacts with cytoplasmic tyrosine kinases of the Tec family and suggest that Nef provides a mechanistic link between HIV-1 and Itk signaling in the viral life cycle.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with TEC blocking peptide

 Reference Product  PubMed Publications
 KIT blocking peptide  >32 publications with TEC and KIT
 LYN blocking peptide  >30 publications with TEC and LYN
 JAK2 blocking peptide  >20 publications with TEC and JAK2
 VAV1 blocking peptide  >19 publications with TEC and VAV1
 GRB2 blocking peptide  >9 publications with TEC and GRB2
 BLNK blocking peptide  >8 publications with TEC and BLNK
 DOK1 blocking peptide  >5 publications with TEC and DOK1
 GRAP2 blocking peptide  >1 publications with TEC and GRAP2
 PLCG1 blocking peptide  >1 publications with TEC and PLCG1
 PLCG2 blocking peptide  >1 publications with TEC and PLCG2

Pathways associated with TEC blocking peptide

 Products by Pathway  Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 EPO Signaling Pathway antibodies  EPO Signaling Pathway Diagram
 FCERI Mediated Ca+2 Mobilization Pathway antibodies  FCERI Mediated Ca+2 Mobilization Pathway Diagram
 Fc Epsilon Receptor (FCERI) Signaling Pathway antibodies  Fc Epsilon Receptor (FCERI) Signaling Pathway Diagram
 IL-3 Signaling Pathway antibodies  IL-3 Signaling Pathway Diagram
 IL-6 Signaling Pathway antibodies  IL-6 Signaling Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Interleukin-3, 5 And GM-CSF Signaling Pathway antibodies  Interleukin-3, 5 And GM-CSF Signaling Pathway Diagram

Diseases associated with TEC blocking peptide

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >143 publications with TEC and Inflammation
 Kidney Diseases Antibodies  >96 publications with TEC and Kidney Diseases
 Carcinoma Antibodies  >93 publications with TEC and Carcinoma
 Necrosis Antibodies  >85 publications with TEC and Necrosis
 Nephritis Antibodies  >41 publications with TEC and Nephritis
 Fibrosis Antibodies  >39 publications with TEC and Fibrosis
 Neoplasms, Experimental Antibodies  >32 publications with TEC and Neoplasms, Experimental
 Liver Diseases Antibodies  >32 publications with TEC and Liver Diseases
 Acute Kidney Injury Antibodies  >27 publications with TEC and Acute Kidney Injury
 Neoplasm Metastasis Antibodies  >26 publications with TEC and Neoplasm Metastasis

Organs/Tissues associated with TEC blocking peptide

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >213 publications with TEC and Kidney
 Bone Marrow Antibodies  >123 publications with TEC and Bone Marrow
 Skin Antibodies  >93 publications with TEC and Skin
 Heart Antibodies  >79 publications with TEC and Heart
 Thyroid Antibodies  >70 publications with TEC and Thyroid
 Muscle Antibodies  >69 publications with TEC and Muscle
 Lung Antibodies  >59 publications with TEC and Lung
 Intestine Antibodies  >35 publications with TEC and Intestine
 Lymph Node Antibodies  >28 publications with TEC and Lymph Node
 Lymph Antibodies  >26 publications with TEC and Lymph
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