Mouse TLR1 Antibody (C-Term) Blocking Peptide

Name: Mouse TLR1 Antibody (C-Term) Blocking Peptide; MyBioSource
Brand: MyBioSource
SKU: MBS9221302
Price: 455 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9221302

Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6,… More details

$455 / 0.5 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

TLR1, Blocking Peptide

Full Product Name

Mouse TLR1 Antibody (C-term) Blocking Peptide

Product Gene Name

Tlr1 blocking peptide

Product Synonym Names

Toll-like receptor 1; Toll/interleukin-1 receptor-like protein; TIL; CD281; Tlr1

Form/Format

The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.

Specificity

The synthetic peptide sequence used to generate the antibody was selected from the C-term region of human Mouse TLR1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.

Preparation and Storage

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Antibody/Peptide Pairs

TLR1 peptide (MBS9221302) is used for blocking the activity of TLR1 antibody (MBS9207864)

Molecular Weight

90,673 Da

Cellular Location

Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, phagosome membrane; Single-pass type I membrane protein

Other Notes

Small volumes of Tlr1 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Tlr1 purchase

MBS9221302 is a blocking peptide targeting Tlr1. Also known as Mouse TLR1 Antibody (C-term) Blocking Peptide.

Additional Details

NCBI/Uniprot data below describe general gene information for Tlr1. It may not necessarily be applicable to this product.

NCBI GI #

20140791

NCBI GeneID

21897

NCBI Accession #

Q9EPQ1.1

UniProt Primary Accession #

Q9EPQ1

UniProt Secondary Accession #

Q9EPW5

UniProt Related Accession #

Q9EPQ1

NCBI Official Full Name

Toll-like receptor 1

NCBI Official Synonym Full Names

toll-like receptor 1

NCBI Official Symbol

Tlr1

UniProt Protein Name

Toll-like receptor 1

UniProt Synonym Protein Names

Toll/interleukin-1 receptor-like protein; TIL; CD_antigen: CD281

Protein Family

Toll-like receptor

UniProt Gene Name

Tlr1

UniProt Synonym Gene Names

TIL

UniProt Entry Name

TLR1_MOUSE

NCBI Protein Information

toll-like receptor 1

UniProt Comments for Tlr1

TLR1: Participates in the innate immune response to microbial agents. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Binds MYD88 (via TIR domain). Interacts with CNPY3. Interacts (via extracellular domain) with TLR2. Ligand binding induces the formation of a heterodimer with TLR2. Ubiquitous. Highly expressed in spleen, ovary, peripheral blood leukocytes, thymus and small intestine. Belongs to the Toll-like receptor family.

Protein type: Membrane protein, integral

Cellular Component: Golgi apparatus; integral to plasma membrane; lipid raft

Molecular Function: protein heterodimerization activity; transmembrane receptor activity

Biological Process: defense response; defense response to bacterium; detection of triacylated bacterial lipoprotein; microglial cell activation; positive regulation of interleukin-6 biosynthetic process; positive regulation of tumor necrosis factor biosynthetic process; response to bacterial lipoprotein; toll-like receptor signaling pathway

Research Articles on Tlr1

1. Activation of MyD88-dependent TLR1/2 signaling by misfolded alpha-synuclein, a protein linked to neurodegenerative disorders.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Tlr1 blocking peptide

Reference Product	PubMed Publications
Tlr2 blocking peptide	>727 publications with Tlr1 and Tlr2
Myd88 blocking peptide	>145 publications with Tlr1 and Myd88
Nod2 blocking peptide	>40 publications with Tlr1 and Nod2
Tirap blocking peptide	>39 publications with Tlr1 and Tirap
Traf6 blocking peptide	>17 publications with Tlr1 and Traf6
Irak2 blocking peptide	>16 publications with Tlr1 and Irak2
Irak1 blocking peptide	>12 publications with Tlr1 and Irak1
Irak4 blocking peptide	>10 publications with Tlr1 and Irak4

Pathways associated with Tlr1 blocking peptide

Products by Pathway	Pathway Diagram
Beta Defensins Pathway antibodies	Beta Defensins Pathway Diagram
Defensins Pathway antibodies	Defensins Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Innate Immune System Pathway antibodies	Innate Immune System Pathway Diagram
Toll-like Receptor Signaling Pathway antibodies	Toll-like Receptor Signaling Pathway Diagram
Toll-like Receptor Signaling Pathway antibodies	Toll-like Receptor Signaling Pathway Diagram
Tuberculosis Pathway antibodies	Tuberculosis Pathway Diagram
Tuberculosis Pathway antibodies	Tuberculosis Pathway Diagram

Diseases associated with Tlr1 blocking peptide

Disease Name	Pubmed Publications
Inflammation Antibodies	>246 publications with Tlr1 and Inflammation
Necrosis Antibodies	>155 publications with Tlr1 and Necrosis
Lung Diseases Antibodies	>49 publications with Tlr1 and Lung Diseases
Kidney Diseases Antibodies	>23 publications with Tlr1 and Kidney Diseases
Liver Diseases Antibodies	>17 publications with Tlr1 and Liver Diseases
Pneumonia Antibodies	>12 publications with Tlr1 and Pneumonia
Colitis Antibodies	>11 publications with Tlr1 and Colitis
Heart Diseases Antibodies	>11 publications with Tlr1 and Heart Diseases
Leprosy Antibodies	>9 publications with Tlr1 and Leprosy
Neoplasms, Experimental Antibodies	>8 publications with Tlr1 and Neoplasms, Experimental

Organs/Tissues associated with Tlr1 blocking peptide

Organ/Tissue Name	Pubmed Publications
Other Antibodies	>203 publications with Tlr1 and Other
Bone Marrow Antibodies	>64 publications with Tlr1 and Bone Marrow
Kidney Antibodies	>48 publications with Tlr1 and Kidney
Spleen Antibodies	>48 publications with Tlr1 and Spleen
Intestine Antibodies	>42 publications with Tlr1 and Intestine
Liver Antibodies	>41 publications with Tlr1 and Liver
Skin Antibodies	>37 publications with Tlr1 and Skin
Lymph Node Antibodies	>24 publications with Tlr1 and Lymph Node
Embryonic Tissue Antibodies	>16 publications with Tlr1 and Embryonic Tissue
Thymus Antibodies	>7 publications with Tlr1 and Thymus