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Mouse TLR6 Antibody (N-Term) Blocking Peptide

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9221310

Participates in the innate immune response to Gram- positive bacteria and fungi. Specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the… More details

$455 / 0.5 mg +1 FREE 8GB USB
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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
TLR6, Blocking Peptide
Full Product Name
Mouse TLR6 Antibody (N-term) Blocking Peptide
Product Gene Name
Tlr6 blocking peptide
Product Synonym Names
Toll-like receptor 6; CD286; Tlr6
Form/Format
The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
Specificity
The synthetic peptide sequence used to generate the antibody was selected from the N-term region of human Mouse TLR6. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Antibody/Peptide Pairs
TLR6 peptide (MBS9221310) is used for blocking the activity of TLR6 antibody (MBS9205577)
Molecular Weight
91,116 Da
Cellular Location
Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, phagosome membrane; Single-pass type I membrane protein. Note: Upon complex formation with CD36 and TLR4, internalized through dynamin-dependent endocytosis
Tissue Location
Detected in thymus, spleen, ovary and lung.

Other Notes

Small volumes of Tlr6 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Tlr6 purchase

MBS9221310 is a blocking peptide targeting Tlr6. Also known as Mouse TLR6 Antibody (N-term) Blocking Peptide.

Additional Details

NCBI/Uniprot data below describe general gene information for Tlr6. It may not necessarily be applicable to this product.

NCBI GI #
157057101
NCBI GeneID
21899
NCBI Accession #
NP_035734
UniProt Primary Accession #
Q9EPW9
UniProt Secondary Accession #
Q9WTQ4
UniProt Related Accession #
Q9EPW9
GenBank Nucleotide #
NM_011604.3
NCBI Official Full Name
toll-like receptor 6
NCBI Official Synonym Full Names
toll-like receptor 6
NCBI Official Symbol
Tlr6
UniProt Protein Name
Toll-like receptor 6
UniProt Synonym Protein Names
CD_antigen: CD286
UniProt Gene Name
Tlr6
UniProt Entry Name
TLR6_MOUSE
NCBI Protein Information
toll-like receptor 6

UniProt Comments for Tlr6

TLR6: Participates in the innate immune response to Gram- positive bacteria and fungi. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2. Belongs to the Toll-like receptor family.

Protein type: Membrane protein, integral; Receptor, misc.

Cellular Component: Golgi apparatus; integral to plasma membrane; lipid raft

Molecular Function: diacylated lipoprotein binding; protein heterodimerization activity; transmembrane receptor activity

Biological Process: defense response to bacterium; detection of diacylated bacterial lipoprotein; inflammatory response; interleukin-1 beta secretion; microglial cell activation; nitric oxide metabolic process; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-6 biosynthetic process; positive regulation of JNK activity; response to bacterial lipoprotein; T-helper 1 type immune response; toll-like receptor signaling pathway
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Research Articles on Tlr6

1. Dengue virus NS1 protein is the viral protein responsible for the activation of TLR2 and TLR6 during Dengue virus infection

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Tlr6 blocking peptide

 Reference Product  PubMed Publications
 Tlr2 blocking peptide  >546 publications with Tlr6 and Tlr2
 Myd88 blocking peptide  >110 publications with Tlr6 and Myd88
 Cd14 blocking peptide  >68 publications with Tlr6 and Cd14
 Nod2 blocking peptide  >27 publications with Tlr6 and Nod2
 Irak2 blocking peptide  >16 publications with Tlr6 and Irak2
 Traf6 blocking peptide  >12 publications with Tlr6 and Traf6
 Cd36 blocking peptide  >12 publications with Tlr6 and Cd36
 Irak1 blocking peptide  >11 publications with Tlr6 and Irak1
 Irak4 blocking peptide  >8 publications with Tlr6 and Irak4

Pathways associated with Tlr6 blocking peptide

 Products by Pathway  Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Toll-like Receptor Signaling Pathway antibodies  Toll-like Receptor Signaling Pathway Diagram
 Toll-like Receptor Signaling Pathway antibodies  Toll-like Receptor Signaling Pathway Diagram
 Tuberculosis Pathway antibodies  Tuberculosis Pathway Diagram
 Tuberculosis Pathway antibodies  Tuberculosis Pathway Diagram

Diseases associated with Tlr6 blocking peptide

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >173 publications with Tlr6 and Inflammation
 Necrosis Antibodies  >103 publications with Tlr6 and Necrosis
 Immune System Diseases Antibodies  >84 publications with Tlr6 and Immune System Diseases
 Lung Diseases Antibodies  >42 publications with Tlr6 and Lung Diseases
 Cardiovascular Diseases Antibodies  >21 publications with Tlr6 and Cardiovascular Diseases
 Pneumonia Antibodies  >16 publications with Tlr6 and Pneumonia
 Atherosclerosis Antibodies  >11 publications with Tlr6 and Atherosclerosis
 Liver Diseases Antibodies  >10 publications with Tlr6 and Liver Diseases
 Kidney Diseases Antibodies  >10 publications with Tlr6 and Kidney Diseases
 Prostatic Neoplasms Antibodies  >7 publications with Tlr6 and Prostatic Neoplasms

Organs/Tissues associated with Tlr6 blocking peptide

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >43 publications with Tlr6 and Bone
 Skin Antibodies  >25 publications with Tlr6 and Skin
 Embryonic Tissue Antibodies  >10 publications with Tlr6 and Embryonic Tissue
 Mammary Gland Antibodies  >1 publications with Tlr6 and Mammary Gland
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