TRIM63 Blocking Peptide – Cat# MBS9626549

TRIM63 Blocking Peptide – The purity is >90%,tested by HPLC and MS. Purity

Name: TRIM63 Blocking Peptide; The purity is >90%,tested by HPLC and MS. Purity; MyBioSource
Brand: MyBioSource
SKU: MBS9626549
Price: 460 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9626549

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the… More details

$460 / 1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

TRIM63, Blocking Peptide

Full Product Name

TRIM63 Blocking Peptide

Product Gene Name

TRIM63 blocking peptide

Product Synonym Names

E3 ubiquitin-protein ligase TRIM63; FLJ32380; IRF; Iris RING finger protein; MURF 1; MURF-1; MuRF1; MURF2; Muscle specific ring finger protein 1; Muscle specific ring finger protein 2; Muscle-specific RING finger protein 1; OTTHUMP00000008701; RING finger protein 28; RNF 28; RNF28; SMRZ; Striated muscle RING zinc finger protein; TRI63_HUMAN; TRIM 63; Trim63; Tripartite motif containing 63; tripartite motif containing 63, E3 ubiquitin protein ligase; Tripartite motif containing protein 63; Tripartite motif-containing protein 63; Ubiquitin ligase TRIM63

Form/Format

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.

Purity/Purification

The purity is >90%,tested by HPLC and MS.

Preparation and Storage

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Antibody/Peptide Pairs

TRIM63 peptide (MBS9626549) is used for blocking the activity of TRIM63 antibody (MBS9607836)

Molecular Weight

36,950 Da

OMIM

606131

Supply Chain Verification

Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.

Notes

For phospho antibody, we provide phospho peptide (0.5mg) and non-phospho peptide (0.5mg)

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Applications Tested/Suitable for TRIM63 blocking peptide

Blocking/Control

Other Notes

Small volumes of TRIM63 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TRIM63 purchase

MBS9626549 is a blocking peptide targeting TRIM63.

Additional Details

NCBI/Uniprot data below describe general gene information for TRIM63. It may not necessarily be applicable to this product.

NCBI GI #

19924163

NCBI GeneID

84676

NCBI Accession #

NP_115977.2

UniProt Primary Accession #

Q969Q1

UniProt Secondary Accession #

Q5T2I1; Q96BD3; Q96KD9; Q9BYV4; B4DN95

UniProt Related Accession #

Q969Q1

GenBank Nucleotide #

NM_032588.3

NCBI Official Full Name

E3 ubiquitin-protein ligase TRIM63

NCBI Official Synonym Full Names

tripartite motif containing 63, E3 ubiquitin protein ligase

NCBI Official Symbol

TRIM63

NCBI Official Synonym Symbols

IRF; SMRZ; MURF1; MURF2; RNF28

UniProt Protein Name

E3 ubiquitin-protein ligase TRIM63

UniProt Synonym Protein Names

Iris RING finger protein; Muscle-specific RING finger protein 1; MuRF-1; MuRF1; RING finger protein 28; Striated muscle RING zinc finger protein; Tripartite motif-containing protein 63

Protein Family

E3 ubiquitin-protein ligase

UniProt Gene Name

TRIM63

UniProt Synonym Gene Names

IRF; MURF1; RNF28; SMRZ; MuRF-1; MuRF1

UniProt Entry Name

TRI63_HUMAN

NCBI Protein Information

E3 ubiquitin-protein ligase TRIM63; ring finger protein 28; iris ring finger protein; muscle specific ring finger protein 2; muscle-specific RING finger protein 1; tripartite motif-containing protein 63; striated muscle RING zinc finger protein

NCBI Summary for TRIM63

This gene encodes a member of the RING zinc finger protein family found in striated muscle and iris. The product of this gene is an E3 ubiquitin ligase that localizes to the Z-line and M-line lattices of myofibrils. This protein plays an important role in the atrophy of skeletal and cardiac muscle and is required for the degradation of myosin heavy chain proteins, myosin light chain, myosin binding protein, and for muscle-type creatine kinase. [provided by RefSeq, Feb 2012]

UniProt Comments for TRIM63

MURF1: E3 ubiquitin ligase. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric- associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.

Protein type: EC 6.3.2.-; Ligase; EC 6.3.2.19; Ubiquitin ligase; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 1p34-p33

Cellular Component: microtubule; cytoplasm; M band; Z disc; nucleus

Molecular Function: signal transducer activity; protein binding; zinc ion binding; ubiquitin-protein ligase activity; titin binding; ligase activity

Biological Process: proteasomal ubiquitin-dependent protein catabolic process; skeletal muscle atrophy; muscle contraction; regulation of gene expression; protein ubiquitination; response to electrical stimulus involved in regulation of muscle adaptation; signal transduction

Research Articles on TRIM63

1. both MuRF1 and MAFbx are enriched in skeletal, cardiac, and smooth muscle--REVIEW

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with TRIM63 blocking peptide

Reference Product	PubMed Publications
TTN blocking peptide	>6 publications with TRIM63 and TTN
SQSTM1 blocking peptide	>3 publications with TRIM63 and SQSTM1
PKM2 blocking peptide	>1 publications with TRIM63 and PKM2
MYOZ1 blocking peptide	>1 publications with TRIM63 and MYOZ1
SUMO2 blocking peptide	>1 publications with TRIM63 and SUMO2

Pathways associated with TRIM63 blocking peptide

Products by Pathway	Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Antigen Processing: Ubiquitination & Proteasome Degradation Pathway antibodies	Antigen Processing: Ubiquitination & Proteasome Degradation Pathway Diagram
Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies	Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
TWEAK Signaling Pathway antibodies	TWEAK Signaling Pathway Diagram

Diseases associated with TRIM63 blocking peptide

Disease Name	Pubmed Publications
Atrophy Antibodies	>237 publications with TRIM63 and Atrophy
Nervous System Diseases Antibodies	>170 publications with TRIM63 and Nervous System Diseases
Muscular Atrophy Antibodies	>161 publications with TRIM63 and Muscular Atrophy
Hypertrophy Antibodies	>57 publications with TRIM63 and Hypertrophy
Disease Models, Animal Antibodies	>53 publications with TRIM63 and Disease Models, Animal
Weight Loss Antibodies	>43 publications with TRIM63 and Weight Loss
Necrosis Antibodies	>36 publications with TRIM63 and Necrosis
Cardiovascular Diseases Antibodies	>35 publications with TRIM63 and Cardiovascular Diseases
Inflammation Antibodies	>34 publications with TRIM63 and Inflammation
Heart Diseases Antibodies	>33 publications with TRIM63 and Heart Diseases

Organs/Tissues associated with TRIM63 blocking peptide

Organ/Tissue Name	Pubmed Publications
Muscle Antibodies	>337 publications with TRIM63 and Muscle
Heart Antibodies	>58 publications with TRIM63 and Heart
Vascular Antibodies	>13 publications with TRIM63 and Vascular
Lung Antibodies	>13 publications with TRIM63 and Lung
Liver Antibodies	>12 publications with TRIM63 and Liver
Embryonic Tissue Antibodies	>9 publications with TRIM63 and Embryonic Tissue
Brain Antibodies	>5 publications with TRIM63 and Brain
Skin Antibodies	>2 publications with TRIM63 and Skin
Uncharacterized Tissue Antibodies	>1 publications with TRIM63 and Uncharacterized Tissue