Phospho-Rat Tsc1(s312) Blocking Peptide

Name: Phospho-Rat Tsc1(s312) Blocking Peptide; MyBioSource
Brand: MyBioSource
SKU: MBS9230800
Price: 455 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9230800

In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (By similarity). Implicated as a tumor suppressor. Involved in microtubule-mediated protein… More details

$455 / 0.5 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

TSC1 (S312), Blocking Peptide

Full Product Name

Phospho-rat TSC1(S312) Blocking Peptide

Product Gene Name

Tsc1 blocking peptide

Product Synonym Names

Hamartin; Tuberous sclerosis 1 protein homolog; Tsc1

Form/Format

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.

Specificity

The synthetic peptide sequence is selected from aa 305-317 of RAT Tsc1

Preparation and Storage

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Antibody/Peptide Pairs

TSC1 (S312) peptide (MBS9230800) is used for blocking the activity of TSC1 (S312) antibody (MBS9200715)

Molecular Weight

129,022 Da

Cellular Location

Cytoplasm. Membrane; Peripheral membrane protein. Note: At steady state found in association with membranes.

Tissue Location

Highly expressed in brain, spleen and kidney, followed by liver and heart

Other Notes

Small volumes of Tsc1 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Tsc1 purchase

MBS9230800 is a blocking peptide targeting Tsc1. Also known as Phospho-rat TSC1(S312) Blocking Peptide.

Additional Details

NCBI/Uniprot data below describe general gene information for Tsc1. It may not necessarily be applicable to this product.

NCBI GI #

11177894

NCBI GeneID

60445

NCBI Accession #

NP_068626.1

UniProt Primary Accession #

Q9Z136

UniProt Related Accession #

Q9Z136

GenBank Nucleotide #

NM_021854.1

NCBI Official Full Name

hamartin

NCBI Official Synonym Full Names

tuberous sclerosis 1

NCBI Official Symbol

Tsc1

UniProt Protein Name

Hamartin

UniProt Synonym Protein Names

Tuberous sclerosis 1 protein homolog

Protein Family

Hamartin

UniProt Gene Name

Tsc1

UniProt Entry Name

TSC1_RAT

NCBI Protein Information

hamartin

UniProt Comments for Tsc1

TSC1: tuberous sclerosis protein 1 (TSC1). May have tumor suppressor activity. Together with tuberin (TSC2), inhibits mammalian target of rapamycin (mTOR)-mediated signaling to eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) and ribosomal protein S6 kinase. Regulated by the phosphatidylinositol 3-kinase/Akt pathway and phosphorylation of tuberin. Phosphorylated by cyclin-dependent kinase 1/cyclin B during the cell cycle.

Protein type: Motility/polarity/chemotaxis; Tumor suppressor

Cellular Component: actin filament; cell cortex; cytoplasm; cytoskeleton; cytosol; growth cone; intracellular membrane-bound organelle; lamellipodium; membrane; nucleus; perinuclear region of cytoplasm; plasma membrane; protein complex; TSC1-TSC2 complex

Molecular Function: chaperone binding; GTPase activating protein binding; GTPase regulator activity; protein binding; protein N-terminus binding

Biological Process: adaptive immune response; adult locomotory behavior; cardiac muscle cell differentiation; cell projection organization and biogenesis; cell-matrix adhesion; cerebral cortex development; glucose import; hippocampus development; kidney development; memory T cell differentiation; myelination; negative regulation of cell proliferation; negative regulation of cell size; negative regulation of insulin receptor signaling pathway; negative regulation of macroautophagy; negative regulation of TOR signaling pathway; negative regulation of translation; nervous system development; neural tube closure; positive regulation of focal adhesion formation; potassium ion transport; protein heterooligomerization; protein stabilization; regulation of actin cytoskeleton organization and biogenesis; regulation of cell cycle; regulation of cell-matrix adhesion; regulation of focal adhesion formation; regulation of GTPase activity; regulation of phosphoprotein phosphatase activity; regulation of protein kinase activity; regulation of stress fiber formation; regulation of translation; response to insulin stimulus; rRNA export from nucleus; synapse organization and biogenesis

Research Articles on Tsc1

1. TSC1 is selectively induced by ischemia in hippocampal CA3 neurons; in CA1 neurons, TSC1 was unaffected by ischemia but was upregulated by ischemic preconditioning preceding ischemia; overexpression of TSC1 increased resistance to oxygen glucose deprivation by inducing productive autophagy

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Tsc1 blocking peptide

Reference Product	PubMed Publications
Tsc2 blocking peptide	>1032 publications with Tsc1 and Tsc2
Mtor blocking peptide	>623 publications with Tsc1 and Mtor
Rheb blocking peptide	>166 publications with Tsc1 and Rheb
Akt1 blocking peptide	>37 publications with Tsc1 and Akt1
Ikbkb blocking peptide	>9 publications with Tsc1 and Ikbkb
Rps6ka1 blocking peptide	>8 publications with Tsc1 and Rps6ka1
Prkaa1 blocking peptide	>3 publications with Tsc1 and Prkaa1
Akt3 blocking peptide	>3 publications with Tsc1 and Akt3
Akt2 blocking peptide	>3 publications with Tsc1 and Akt2

Pathways associated with Tsc1 blocking peptide

Products by Pathway	Pathway Diagram
AMPK Signaling Pathway antibodies	AMPK Signaling Pathway Diagram
AMPK Signaling Pathway antibodies	AMPK Signaling Pathway Diagram
Cellular Responses To Stress Pathway antibodies	Cellular Responses To Stress Pathway Diagram
Choline Metabolism In Cancer Pathway antibodies	Choline Metabolism In Cancer Pathway Diagram
Choline Metabolism In Cancer Pathway antibodies	Choline Metabolism In Cancer Pathway Diagram
Energy Dependent Regulation Of MTOR By LKB1-AMPK Pathway antibodies	Energy Dependent Regulation Of MTOR By LKB1-AMPK Pathway Diagram
Gene Expression Pathway antibodies	Gene Expression Pathway Diagram
Generic Transcription Pathway antibodies	Generic Transcription Pathway Diagram
IGF1R Signaling Cascade Pathway antibodies	IGF1R Signaling Cascade Pathway Diagram
IRS-mediated Signalling Pathway antibodies	IRS-mediated Signalling Pathway Diagram

Diseases associated with Tsc1 blocking peptide

Disease Name	Pubmed Publications
Tuberous Sclerosis Antibodies	>1125 publications with Tsc1 and Tuberous Sclerosis
Epilepsy Antibodies	>192 publications with Tsc1 and Epilepsy
Brain Diseases Antibodies	>152 publications with Tsc1 and Brain Diseases
Lymphangioleiomyomatosis Antibodies	>111 publications with Tsc1 and Lymphangioleiomyomatosis
Kidney Diseases Antibodies	>107 publications with Tsc1 and Kidney Diseases
Cardiovascular Diseases Antibodies	>47 publications with Tsc1 and Cardiovascular Diseases
Tuberous Sclerosis 1 Antibodies	>47 publications with Tsc1 and Tuberous Sclerosis 1
Carcinoma, Renal Cell Antibodies	>45 publications with Tsc1 and Carcinoma, Renal Cell
Liver Neoplasms Antibodies	>35 publications with Tsc1 and Liver Neoplasms
Neoplasms, Experimental Antibodies	>33 publications with Tsc1 and Neoplasms, Experimental

Organs/Tissues associated with Tsc1 blocking peptide

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>365 publications with Tsc1 and Brain
Prostate Antibodies	>9 publications with Tsc1 and Prostate
Uncharacterized Tissue Antibodies	>1 publications with Tsc1 and Uncharacterized Tissue