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Phospho-Rat Tsc2(t1373) Blocking Peptide

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9230803

In complex with TSC1, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase- activating protein (GAP) for the small GTPase RHEB, a direct activator of the… More details

$455 / 0.5 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
TSC2 (T1373), Blocking Peptide
Full Product Name
Phospho-rat TSC2(T1373) Blocking Peptide
Product Gene Name
Product Synonym Names
Tuberin; Tuberous sclerosis 2 protein homolog; Tsc2
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Specificity
The synthetic peptide sequence is selected from aa 1366-1380 of RAT Tsc2
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Antibody/Peptide Pairs
Molecular Weight
194,006 Da
Tissue Location
CNS, uterus, heart, skeletal muscle, kidney and spleen

Other Notes

Small volumes of Tsc2 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Tsc2 purchase

MBS9230803 is a blocking peptide targeting Tsc2. Also known as Phospho-rat TSC2(T1373) Blocking Peptide.

Additional Details

NCBI/Uniprot data below describe general gene information for Tsc2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
tuberin
NCBI Official Synonym Full Names
tuberous sclerosis 2
NCBI Official Symbol
Tsc2
NCBI Official Synonym Symbols
Rc
UniProt Protein Name
Tuberin
UniProt Synonym Protein Names
Tuberous sclerosis 2 protein homolog
Protein Family
UniProt Gene Name
Tsc2
UniProt Entry Name
TSC2_RAT
NCBI Protein Information
tuberin

NCBI Summary for Tsc2

acts as a tumor suppressor; may play a role in cell cycle regulation; acute phase response, and negative regulation of cell proliferation [RGD, Feb 2006]

UniProt Comments for Tsc2

In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. May also play a role in microtubule-mediated protein transport. Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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