USP16 Antibody (N-Term) Blocking Peptide

Name: USP16 Antibody (N-Term) Blocking Peptide; MyBioSource
Brand: MyBioSource
SKU: MBS9224587
Price: 455 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9224587

Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of… More details

$455 / 0.5 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

USP16, Blocking Peptide

Full Product Name

USP16 Antibody (N-term) Blocking Peptide

Product Gene Name

USP16 blocking peptide

Product Synonym Names

Ubiquitin carboxyl-terminal hydrolase 16; 341912; Deubiquitinating enzyme 16; Ubiquitin thioesterase 16; Ubiquitin-processing protease UBP-M; Ubiquitin-specific-processing protease 16; USP16

Form/Format

The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.

Specificity

The synthetic peptide sequence used to generate the antibody was selected from the N-term region of human USP16. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.

Preparation and Storage

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Molecular Weight

46,599 Da

OMIM

604735

Cellular Location

Nucleus.

Tissue Location

Present in all the tissues examined including fetal brain, lung, liver, kidney, and adult heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas

Other Notes

Small volumes of USP16 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for USP16 purchase

MBS9224587 is a blocking peptide targeting USP16. Also known as USP16 Antibody (N-term) Blocking Peptide.

Additional Details

NCBI/Uniprot data below describe general gene information for USP16. It may not necessarily be applicable to this product.

NCBI GI #

6686071

NCBI GeneID

10600

NCBI Accession #

Q9Y5T5.1

UniProt Primary Accession #

Q9Y5T5

UniProt Secondary Accession #

Q53GP7; Q53HA0; Q5VKN8; Q8NEL3; Q9H3E6; A8MU43; B3KN13; B4DFV8; B4DY37; D3DSD9

UniProt Related Accession #

Q9Y5T5

NCBI Official Full Name

Ubiquitin carboxyl-terminal hydrolase 16

NCBI Official Synonym Full Names

ubiquitin specific peptidase 16

NCBI Official Symbol

USP16

NCBI Official Synonym Symbols

UBPM; UBP-M

UniProt Protein Name

Ubiquitin carboxyl-terminal hydrolase 16

UniProt Synonym Protein Names

Deubiquitinating enzyme 16

UniProt Gene Name

USP16

UniProt Entry Name

UBP16_HUMAN

NCBI Protein Information

ubiquitin carboxyl-terminal hydrolase 16

NCBI Summary for USP16

This gene encodes a deubiquitinating enzyme that is phosphorylated at the onset of mitosis and then dephosphorylated at the metaphase/anaphase transition. It can deubiquitinate H2A, one of two major ubiquitinated proteins of chromatin, in vitro and a mutant form of the protein was shown to block cell division. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

UniProt Comments for USP16

USP16: a ubiquitous ubiquitin-processing protease that may de-ubiquitinate one or more critical proteins that are involved in the condensation of mitotic chromosomes, possibly acting selectively on histones H2A and H2B, the major ubiquitinated proteins of chromatin. Is phosphorylated at the onset of mitosis and dephosphorylated during the metaphase/anaphase transition.

Protein type: EC 3.4.19.12; Ubiquitin conjugating system; Protease; Ubiquitin-specific protease

Chromosomal Location of Human Ortholog: 21q22.11

Cellular Component: cytoplasm; nucleus

Molecular Function: cysteine-type endopeptidase activity; histone binding; transcription coactivator activity; ubiquitin binding; ubiquitin-specific protease activity; zinc ion binding

Biological Process: cell cycle; histone deubiquitination; mitosis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of translational elongation; protein homotetramerization; regulation of transcription from RNA polymerase II promoter; response to DNA damage stimulus

Research Articles on USP16

1. The data unveil a unique mechanism by which Usp16 promotes the localization and maintenance of Plk1 on the kinetochores for proper chromosome alignment.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with USP16 blocking peptide

Reference Product	PubMed Publications
HERC2 blocking peptide	>1 publications with USP16 and HERC2

Pathways associated with USP16 blocking peptide

Products by Pathway	Pathway Diagram
Integrated Breast Cancer Pathway antibodies	Integrated Breast Cancer Pathway Diagram

Diseases associated with USP16 blocking peptide

Disease Name	Pubmed Publications
Neurobehavioral Manifestations Antibodies	>3 publications with USP16 and Neurobehavioral Manifestations
Liver Diseases Antibodies	>1 publications with USP16 and Liver Diseases
Fatty Liver Antibodies	>1 publications with USP16 and Fatty Liver
Anemia Antibodies	>1 publications with USP16 and Anemia
Diabetes Mellitus Antibodies	>1 publications with USP16 and Diabetes Mellitus
Body Weight Changes Antibodies	>1 publications with USP16 and Body Weight Changes
Lung Neoplasms Antibodies	>1 publications with USP16 and Lung Neoplasms
Necrosis Antibodies	>1 publications with USP16 and Necrosis

Organs/Tissues associated with USP16 blocking peptide

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>3 publications with USP16 and Blood
Bone Marrow Antibodies	>2 publications with USP16 and Bone Marrow
Lymph Node Antibodies	>1 publications with USP16 and Lymph Node
Thyroid Antibodies	>1 publications with USP16 and Thyroid
Lymph Antibodies	>1 publications with USP16 and Lymph
Lung Antibodies	>1 publications with USP16 and Lung
Muscle Antibodies	>1 publications with USP16 and Muscle
Mammary Gland Antibodies	>1 publications with USP16 and Mammary Gland
Liver Antibodies	>1 publications with USP16 and Liver