VAMP7 Antibody (Center) Blocking Peptide

This gene encodes a transmembrane protein that is a member of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) family. The encoded protein localizes to late endosomes and lysosomes and is involved in the fusion of transport vesicles to their target membranes. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010]

VAMP7: Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocytosis of late endocytic vesicles during phagosome formation. Belongs to the synaptobrevin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: Xq28 and Yq12

Cellular Component: cytoplasm; endoplasmic reticulum membrane; intracellular membrane-bound organelle; lamellipodium; late endosome membrane; lysosomal membrane; membrane; neuron projection; phagocytic vesicle; plasma membrane; pseudopodium; secretory granule; secretory granule membrane; SNARE complex; trans-Golgi network

Molecular Function: protein binding; SNAP receptor activity; SNARE binding

Biological Process: calcium ion-dependent exocytosis; endocytosis; endosome to lysosome transport; eosinophil degranulation; ER to Golgi vesicle-mediated transport; natural killer cell degranulation; neutrophil degranulation; phagocytosis, engulfment; post-Golgi vesicle-mediated transport; vesicle fusion; vesicle-mediated transport