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YAP Blocking Peptide – The purity is >90%,tested by HPLC and MS. Purity

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9623361

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the… More details

$460 / 1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
YAP, Blocking Peptide
Full Product Name
YAP Blocking Peptide
Product Gene Name
YAP blocking peptide
Product Synonym Gene Name
YAP1
Product Synonym Names
65 kDa Yes associated protein; 65 kDa Yes-associated protein; COB1; YAp 1; YAP 65; YAP; YAP1; YAP1_HUMAN; YAP2; YAP65; yes-associated protein delta; Yes associated protein 1 65kDa; Yes associated protein 1; Yes associated protein 2; yes associated protein beta; YKI; Yorkie homolog
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.
Purity/Purification
The purity is >90%,tested by HPLC and MS.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Antibody/Peptide Pairs
YAP peptide (MBS9623361) is used for blocking the activity of YAP antibody (MBS9604644)
Molecular Weight
54,462 Da
Chromosome Location
Chromosome: 11; NC_000011.9 (101981192..102104154). Location: 11q13
OMIM
606608
Supply Chain Verification
Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.
Notes
For phospho antibody, we provide phospho peptide (0.5mg) and non-phospho peptide (0.5mg)
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for YAP blocking peptide
Blocking/Control

Other Notes

Small volumes of YAP blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for YAP purchase

MBS9623361 is a blocking peptide targeting YAP.

Additional Details

NCBI/Uniprot data below describe general gene information for YAP. It may not necessarily be applicable to this product.

NCBI GI #
194306653
NCBI GeneID
10413
NCBI Accession #
NP_001123617.1
UniProt Primary Accession #
P46937
UniProt Secondary Accession #
Q7Z574; B4DTY1; B7ZA01; E3WEB5; E3WEB6; E9PRV2; F5H202; K0KQ18; K0KYZ8; K0L195; K0L1G3
UniProt Related Accession #
P46937
GenBank Nucleotide #
NM_001130145.2
NCBI Official Full Name
yorkie homolog isoform 1
NCBI Official Synonym Full Names
Yes-associated protein 1
NCBI Official Symbol
YAP1
NCBI Official Synonym Symbols
YAP; YKI; YAP2; YAP65
UniProt Protein Name
Yorkie homolog
UniProt Synonym Protein Names
65 kDa Yes-associated protein
Protein Family
YAP1-binding protein
UniProt Gene Name
YAP1
UniProt Synonym Gene Names
YAP65; YAP65
UniProt Entry Name
YAP1_HUMAN
NCBI Protein Information
yorkie homolog; yes-associated protein 2; yes-associated protein beta; yes-associated protein delta; 65 kDa Yes-associated protein

NCBI Summary for YAP

This gene encodes the human ortholog of chicken YAP protein which binds to the SH3 domain of the Yes proto-oncogene product. This protein contains a WW domain that is found in various structural, regulatory and signaling molecules in yeast, nematode, and mammals, and may be involved in protein-protein interaction. [provided by RefSeq, Jul 2008]
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UniProt Comments for YAP

YAP1: an adaptor protein that binds to HER4 and the SH3 domain of the Yes tyrosine kinase. Associates with multiple transcription factors in the nucleus, and appears to be a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus. Contains a WW domain that is found in various structural, regulatory and signaling molecules.

Protein type: Oncoprotein; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: nucleoplasm; transcription factor complex; membrane; cytoplasm; cell junction; cytosol; nucleus

Molecular Function: protein binding; transcription coactivator activity; chromatin binding; transcription corepressor activity

Biological Process: paraxial mesoderm development; transcription initiation from RNA polymerase II promoter; somatic stem cell maintenance; lateral mesoderm development; cell morphogenesis; negative regulation of epithelial cell differentiation; notochord development; positive regulation of organ growth; keratinocyte differentiation; cell proliferation; positive regulation of cell proliferation; gene expression; positive regulation of transcription from RNA polymerase II promoter; vasculogenesis; response to DNA damage stimulus

Disease: Coloboma, Ocular, With Or Without Hearing Impairment, Cleft Lip/palate, And/or Mental Retardation
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Research Articles on YAP

1. we provide evidence that YAP overexpression plays an important role in the chemoresistance of hepatocellullar carcinoma cells to doxorubicin.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with YAP blocking peptide

 Reference Product  PubMed Publications
 TEAD1 blocking peptide  >8 publications with YAP and TEAD1
 RUNX2 blocking peptide  >4 publications with YAP and RUNX2
 TEAD4 blocking peptide  >3 publications with YAP and TEAD4
 WBP1 blocking peptide  >3 publications with YAP and WBP1
 TP53BP2 blocking peptide  >3 publications with YAP and TP53BP2
 TEAD2 blocking peptide  >2 publications with YAP and TEAD2
 RUNX1 blocking peptide  >2 publications with YAP and RUNX1
 ERBB4 blocking peptide  >2 publications with YAP and ERBB4
 WBP2 blocking peptide  >2 publications with YAP and WBP2
 TEAD3 blocking peptide  >1 publications with YAP and TEAD3

Pathways associated with YAP blocking peptide

 Products by Pathway  Pathway Diagram
 ErbB4 Signaling Events Pathway antibodies  ErbB4 Signaling Events Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Nuclear Signaling By ERBB4 Pathway antibodies  Nuclear Signaling By ERBB4 Pathway Diagram
 PPARA Activates Gene Expression Pathway antibodies  PPARA Activates Gene Expression Pathway Diagram

Diseases associated with YAP blocking peptide

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >64 publications with YAP and Neoplasms
 Drug Toxicity Antibodies  >29 publications with YAP and Drug Toxicity
 Cell Transformation, Neoplastic Antibodies  >12 publications with YAP and Cell Transformation, Neoplastic
 Disease Models, Animal Antibodies  >9 publications with YAP and Disease Models, Animal
 Carcinoma, Squamous Cell Antibodies  >9 publications with YAP and Carcinoma, Squamous Cell
 Lung Neoplasms Antibodies  >9 publications with YAP and Lung Neoplasms
 Neoplasms, Experimental Antibodies  >9 publications with YAP and Neoplasms, Experimental
 Liver Neoplasms Antibodies  >8 publications with YAP and Liver Neoplasms
 Nervous System Diseases Antibodies  >8 publications with YAP and Nervous System Diseases
 Breast Neoplasms Antibodies  >8 publications with YAP and Breast Neoplasms

Organs/Tissues associated with YAP blocking peptide

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >14 publications with YAP and Lung
 Brain Antibodies  >10 publications with YAP and Brain
 Muscle Antibodies  >10 publications with YAP and Muscle
 Liver Antibodies  >8 publications with YAP and Liver
 Intestine Antibodies  >7 publications with YAP and Intestine
 Vascular Antibodies  >6 publications with YAP and Vascular
 Skin Antibodies  >6 publications with YAP and Skin
 Stomach Antibodies  >5 publications with YAP and Stomach
 Ovary Antibodies  >5 publications with YAP and Ovary
 Bone Antibodies  >5 publications with YAP and Bone
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