C4BPB Recombinant Protein – Cat# MBS144974

Complement Component 4 Beta (C4BPB) Recombinant Protein

Name: C4BPB Recombinant Protein; MyBioSource
Brand: MyBioSource
SKU: MBS144974
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS144974

Description: C4BPB Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 260 amino acids (18-252 a.a) and having a molecular mass of 29kDa.C4BPB is fused to a 25 amino acid His-tag at N-terminus & purified by… More details

$250 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Complement Component 4 Beta (C4BPB), Recombinant Protein

Full Product Name

Recombinant Human Complement Component 4 Binding Protein, Beta

Product Gene Name

C4BPB recombinant protein

Product Synonym Names

C4b-binding protein beta chain, C4BPB, C4BP.

Sequence

MGSSHHH HHH SSGLVPRGSH MGSHMS DAEH CPELPPVDNS IFVAKEVEGQ ILGTYVCIKG YHLVGKKTLF CNASKEWDNT TTECRLGHCP DPVLVNGEFS SSGPVNVSDK ITFMCNDHYI LKGSNRSQCL EDHTWAPPFP ICKSRDCDPP GNPVHGYFEG NNFTLGSTIS YYCEDRYYLV GVQEQQCVDG EWSSALPVCK LIQEAPKPEC EKALLAFQES KNLCEAMENF MQQLKESGMT MEELKYSLEL KKAELKAKLL .

Host

E Coli

Form/Format

C4BPB protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH8.0) and 10% glycerol and 0.15M NaCl.
Sterile Filtered colorless solution.

Purity/Purification

Greater than 90% as determined by SDS-PAGE.

Preparation and Storage

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

Molecular Weight

28,286 Da

OMIM

120831

3D Structure

ModBase 3D Structure for P20851

Product Categories/Family for C4BPB recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins; Complement Component

Other Notes

Small volumes of C4BPB recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for C4BPB purchase

MBS144974 is a recombinant protein targeting C4BPB. Also known as Recombinant Human Complement Component 4 Binding Protein, Beta. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for C4BPB. It may not necessarily be applicable to this product.

NCBI GI #

4502505

NCBI GeneID

725

NCBI Accession #

NP_000707.1

UniProt Primary Accession #

P20851

UniProt Secondary Accession #

Q5VVR0; Q9BS25; A5JYP8; D3DT81

UniProt Related Accession #

P20851

GenBank Nucleotide #

NM_000716.3

NCBI Official Full Name

C4b-binding protein beta chain isoform 1

NCBI Official Synonym Full Names

complement component 4 binding protein, beta

NCBI Official Symbol

C4BPB

NCBI Official Synonym Symbols

C4BP

UniProt Protein Name

C4b-binding protein beta chain

Protein Family

C4b-binding protein

UniProt Gene Name

C4BPB

UniProt Entry Name

C4BPB_HUMAN

NCBI Protein Information

C4b-binding protein beta chain

NCBI Summary for C4BPB

This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. A single, unique beta-chain encoded by this gene assembles with seven identical alpha-chains into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. C4b-binding protein has a regulatory role in the coagulation system also, mediated through the beta-chain binding of protein S, a vitamin K-dependent protein that serves as a cofactor of activated protein C. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Alternative splicing gives rise to multiple transcript variants. [provided by RefSeq, Jul 2008]

UniProt Comments for C4BPB

C4BPB: Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. It also interacts with anticoagulant protein S and with serum amyloid P component. The beta chain binds protein S. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 1q32

Cellular Component: extracellular space; extracellular region; plasma membrane

Molecular Function: protein binding

Biological Process: negative regulation of complement activation, classical pathway; positive regulation of protein catabolic process; regulation of complement activation; innate immune response; blood coagulation; complement activation, classical pathway

Research Articles on C4BPB

1. Binding of complement inhibitor C4b-binding protein to a highly virulent Streptococcus pyogenes M1 strain is mediated by protein H and enhances adhesion to and invasion of endothelial cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with C4BPB recombinant protein

Reference Product	PubMed Publications
C4BPA recombinant protein	>23 publications with C4BPB and C4BPA
PROS1 recombinant protein	>2 publications with C4BPB and PROS1
FOXA2 recombinant protein	>1 publications with C4BPB and FOXA2
NFIC recombinant protein	>1 publications with C4BPB and NFIC
CFI recombinant protein	>1 publications with C4BPB and CFI

Pathways associated with C4BPB recombinant protein

Products by Pathway	Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement Cascade Pathway antibodies	Complement Cascade Pathway Diagram
FOXA1 Transcription Factor Network Pathway antibodies	FOXA1 Transcription Factor Network Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Innate Immune System Pathway antibodies	Innate Immune System Pathway Diagram
Pertussis Pathway antibodies	Pertussis Pathway Diagram
Pertussis Pathway antibodies	Pertussis Pathway Diagram
Regulation Of Complement Cascade Pathway antibodies	Regulation Of Complement Cascade Pathway Diagram

Diseases associated with C4BPB recombinant protein

Disease Name	Pubmed Publications
Liver Diseases Antibodies	>3 publications with C4BPB and Liver Diseases
Liver Neoplasms Antibodies	>3 publications with C4BPB and Liver Neoplasms
Carcinoma, Hepatocellular Antibodies	>3 publications with C4BPB and Carcinoma, Hepatocellular
Edema Antibodies	>1 publications with C4BPB and Edema
Brain Diseases Antibodies	>1 publications with C4BPB and Brain Diseases
Hypertension Antibodies	>1 publications with C4BPB and Hypertension
Cardiovascular Diseases Antibodies	>1 publications with C4BPB and Cardiovascular Diseases

Organs/Tissues associated with C4BPB recombinant protein

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>3 publications with C4BPB and Liver