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C4c protein :: Complement Component 4c Protein

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Catalog # MBS173069
Unit / Price
  0.1 mg  /  $155 +1 FREE 8GB USB
  1 mg  /  $230 +1 FREE 8GB USB
  10 mg  /  $1,110 +1 FREE 8GB USB
C4c protein
Product Name

Complement Component 4c (C4c), Protein

Also Known As

Complement C4c (C4c), Human Plasma

Product Synonym Names
C4; Complement Component 4 (C4), >95% (SDS-PAGE) - Liquid
Product Gene Name
Product Synonym Gene Name
DAMC-258G8.6; C4; C4A2; C4A3; C4A4; C4A6; C4AD; C4S; CO4; CPAMD2; RG; DADB-112B14.11-001; C4B1; C4B12; C4B2; C4B3; C4B5; C4BD; C4B_2; C4F; CH; CO4; CPAMD3; C4B[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
597
OMIM
120830
Purity/Purification
> 95% (SDS-PAGE)
Form/Format
Liquid
Source
Human Plasma
Recertification
3 years
Protein
>= 1.0 mg/mL (A280 E=0.92)
Preparation and Storage
At -20 degree C
Other Notes
Small volumes of C4c protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
C4c protein
MyBioSource sells Human Complement C4 (C4) for research and diagnostic manufacturing.

Custom preparations, technical support, bulk quantities and aliquoting available.

Human Complement proteins: It is thought that the complement system might play a role in many diseases with an immune component, such as Alzheimer's disease, asthma, lupus erythematosus, various forms of arthritis, autoimmune heart disease and multiple sclerosis.

Deficiencies of the terminal pathway predispose to both autoimmune disease and infections (particularly meningitis).
Applications Tested/Suitable for C4c protein
Western Blot (WB)
NCBI/Uniprot data below describe general gene information for C4c. It may not necessarily be applicable to this product.
NCBI GeneID
UniProt Secondary Accession #
Molecular Weight
67,033 Da
NCBI Official Full Name
Complement component 4 binding protein, alpha
NCBI Official Synonym Full Names
complement component 4 binding protein, alpha
NCBI Official Symbol
C4BPA  [Similar Products]
NCBI Official Synonym Symbols
PRP; C4BP
  [Similar Products]
NCBI Protein Information
C4b-binding protein alpha chain; proline-rich protein
UniProt Protein Name
C4b-binding protein alpha chain
UniProt Synonym Protein Names
Proline-rich protein; PRP
UniProt Gene Name
C4BPA  [Similar Products]
UniProt Synonym Gene Names
C4BP; C4bp; PRP  [Similar Products]
UniProt Entry Name
C4BPA_HUMAN
NCBI Summary for C4c
This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. Along with a single, unique beta-chain, seven identical alpha-chains encoded by this gene assemble into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Two pseudogenes of this gene are also found in the cluster. [provided by RefSeq, Jul 2008]
UniProt Comments for C4c
C4BPA: Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1q32

Cellular Component: extracellular space; plasma membrane; extracellular region

Molecular Function: protein binding

Biological Process: negative regulation of complement activation, classical pathway; regulation of complement activation; positive regulation of protein catabolic process; innate immune response; complement activation, classical pathway
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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