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CD3 Delta (CD3delta) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS188301

The protein encoded by this gene is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four… More details

$290 / 0.01 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CD3 delta (CD3delta), Recombinant Protein
Full Product Name
Human CD3 delta Protein, hFc Tag
Product Gene Name
CD3delta recombinant protein
Product Synonym Names
CD3D; CD3-DELTA; T3D
Sequence
CD3D (Phe22-Ala 105) + hFc (Glu99-Ala 330)&CD3E (Asp23-Asp 126) + hFc (Glu99-Ala 330)
Host
HEK293 cells
Form/Format
Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose is added as protectants before lyophilization.
Purity/Purification
Affinity purification
Preparation and Storage
Store at -80 degree C for 12 months (Avoid repeated freezing and thawing)
Molecular Weight
171
OMIM
phenotype 615617
3D Structure
ModBase 3D Structure for P04234
Origin
Human
Reconstitution
Reconstitute with deionized water
Tag
C-Human Fc

SDS-Page of CD3delta recombinant protein

Figure 1. Human CD3D Protein, His Tag on SDS-PAGE under reducing condition.
Human CD3delta Recombinant Protein – Cat# MBS188301

Other Notes

Small volumes of CD3delta recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD3delta purchase

MBS188301 is a recombinant protein targeting CD3delta. Also known as Human CD3 delta Protein, hFc Tag. Host: HEK293 cells.

Additional Details

NCBI/Uniprot data below describe general gene information for CD3delta. It may not necessarily be applicable to this product.

NCBI GI #
115985
NCBI GeneID
915
NCBI Accession #
P04234.1
UniProt Primary Accession #
P04234
UniProt Secondary Accession #
A8MVP6
UniProt Related Accession #
P04234
NCBI Official Full Name
T-cell surface glycoprotein CD3 delta chain
NCBI Official Synonym Full Names
CD3d molecule, delta (CD3-TCR complex)
NCBI Official Symbol
CD3D
NCBI Official Synonym Symbols
T3D; IMD19; CD3-DELTA
UniProt Protein Name
T-cell surface glycoprotein CD3 delta chain
UniProt Synonym Protein Names
T-cell receptor T3 delta chain; CD_antigen: CD3d
Protein Family
T-cell surface glycoprotein
UniProt Gene Name
CD3D
UniProt Synonym Gene Names
T3D
UniProt Entry Name
CD3D_HUMAN
NCBI Protein Information
T-cell surface glycoprotein CD3 delta chain; OKT3, delta chain; CD3 antigen, delta subunit; T-cell receptor T3 delta chain; CD3d antigen, delta polypeptide (TiT3 complex)

UniProt Comments for CD3delta

CD3D: a T cell surface glycoprotein that is a component of the T cell antigen receptor. A defect in this protein causes a severe combined immunodeficiency characterized by the absence of T cells but normal B cells. Contains 1 ITAM domain.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 11q23

Cellular Component: T cell receptor complex; cytoplasm; plasma membrane; integral to membrane; alpha-beta T cell receptor complex

Molecular Function: transmembrane receptor activity; protein heterodimerization activity; transcription coactivator activity

Biological Process: regulation of immune response; cell surface receptor linked signal transduction; T cell costimulation; positive regulation of transcription from RNA polymerase II promoter; T cell receptor signaling pathway; T cell differentiation; positive thymic T cell selection

Disease: Immunodeficiency 19
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Research Articles on CD3delta

1. Two cases of SCID with CD3delta gene mutation in Mexican Mennonite infants are described.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CD3delta recombinant protein

 Reference Product  PubMed Publications
 CD3G recombinant protein  >15 publications with CD3delta and CD3G
 CD3E recombinant protein  >13 publications with CD3delta and CD3E
 LCK recombinant protein  >5 publications with CD3delta and LCK
 ZAP70 recombinant protein  >4 publications with CD3delta and ZAP70
 CD8A recombinant protein  >4 publications with CD3delta and CD8A
 CD247 recombinant protein  >4 publications with CD3delta and CD247
 ITK recombinant protein  >3 publications with CD3delta and ITK
 FYN recombinant protein  >2 publications with CD3delta and FYN
 CD8B recombinant protein  >1 publications with CD3delta and CD8B

Pathways associated with CD3delta recombinant protein

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Costimulation By The CD28 Family Pathway antibodies  Costimulation By The CD28 Family Pathway Diagram
 Downstream TCR Signaling Pathway antibodies  Downstream TCR Signaling Pathway Diagram
 Downstream Signaling In Naive CD8+ T Cells Pathway antibodies  Downstream Signaling In Naive CD8+ T Cells Pathway Diagram
 Generation Of Second Messenger Molecules Pathway antibodies  Generation Of Second Messenger Molecules Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram

Diseases associated with CD3delta recombinant protein

 Disease Name  Pubmed Publications
 Lymphoma Antibodies  >7 publications with CD3delta and Lymphoma
 Inflammation Antibodies  >5 publications with CD3delta and Inflammation
 Severe Combined Immunodeficiency Antibodies  >4 publications with CD3delta and Severe Combined Immunodeficiency
 Breast Neoplasms Antibodies  >3 publications with CD3delta and Breast Neoplasms
 Necrosis Antibodies  >3 publications with CD3delta and Necrosis
 Anemia Antibodies  >1 publications with CD3delta and Anemia
 Uterine Neoplasms Antibodies  >1 publications with CD3delta and Uterine Neoplasms
 Myocardial Infarction Antibodies  >1 publications with CD3delta and Myocardial Infarction
 Lung Neoplasms Antibodies  >1 publications with CD3delta and Lung Neoplasms

Organs/Tissues associated with CD3delta recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >21 publications with CD3delta and Blood
 Thymus Antibodies  >4 publications with CD3delta and Thymus
 Heart Antibodies  >3 publications with CD3delta and Heart
 Intestine Antibodies  >2 publications with CD3delta and Intestine
 Bone Marrow Antibodies  >2 publications with CD3delta and Bone Marrow
 Spleen Antibodies  >1 publications with CD3delta and Spleen
 Lymph Node Antibodies  >1 publications with CD3delta and Lymph Node
 Lung Antibodies  >1 publications with CD3delta and Lung
 Muscle Antibodies  >1 publications with CD3delta and Muscle
 Eye Antibodies  >1 publications with CD3delta and Eye
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