CD325 (CDH2) ELISA Kit for Rat

CDH2: Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density. Interacts with CDCP1. Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Interacts with PCDH8; this complex may also include TAOK2. The interaction with PCDH8 may lead to internalization through TAOK2/p38 MAPK pathway.

Protein type: Membrane protein, integral; Cell adhesion; Motility/polarity/chemotaxis

Cellular Component: adherens junction; apical plasma membrane; basolateral plasma membrane; catenin complex; cell-cell adherens junction; cortical actin cytoskeleton; cytoplasm; fascia adherens; focal adhesion; integral to membrane; intercellular junction; lamellipodium; membrane; plasma membrane; protein complex; synapse; T-tubule

Molecular Function: alpha-catenin binding; beta-catenin binding; calcium ion binding; enzyme binding; gamma-catenin binding; nitric-oxide synthase binding; protein binding; protein complex binding; protein kinase binding; protein phosphatase binding

Biological Process: blood vessel morphogenesis; brain morphogenesis; calcium-dependent cell-cell adhesion; cell adhesion; cell migration; cell-cell adhesion; cerebral cortex development; glial cell differentiation; heterophilic cell adhesion; homeostasis of number of cells; homophilic cell adhesion; positive regulation of MAPKKK cascade; protein heterooligomerization; radial glial cell differentiation; regulation of axonogenesis; regulation of myelination; regulation of protein localization; regulation of Rho protein signal transduction; striated muscle cell differentiation; synaptogenesis; telencephalon development