Human ABAT cDNA Clone Expression Plasmid – Cat# MBS1276244

ABAT cDNA Clone – 4-Aminobutyrate Aminotransferase (Human)

Name: ABAT cDNA Clone; 4-Aminobutyrate Aminotransferase; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1276244
Price: 400 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1276244

MBS1276244 is a cDNA clone targeting ABAT. More details

$400 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

ABAT, cDNA Clone

Full Product Name

ABAT cDNA Clone

Product Gene Name

ABAT cdna clone

Sequence

atggcctcca tgttgctcgc ccagcgcctg gcctgcagct tccagcacag ctaccgcctg ctggtgcctg gatccagaca cattagtcaa gctgcagcca aagtcgacgt tgaatttgat tatgatgggc ctctgatgaa gacggaagtc ccagggccta gatctcagga gttaatgaaa cagctgaata taattcagaa tgcagaggct gtgcattttt tctgcaatta cgaagagagc cgaggcaatt acctggttga tgtggacggc aaccgaatgc tggatcttta ttcccagatc tcctctgtcc ccataggtta cagccacccc gccctgctga aactcatcca acagcctcaa aatgcgagca tgtttgtcaa cagacccgcc ctcggaatcc tgcctccgga gaactttgtg gagaagctcc ggcagtcctt gctctcggtg gctcccaaag ggatgtccca gctcatcacc atggcctgcg gctcctgctc caatgaaaac gccttaaaga ccatcttcat gtggtaccgg agcaaggaaa gagggcagag gggcttctcc caggaggagc tggagacgtg catgattaac caggcccctg gctgccccga ctacagcatc ctctccttca tgggcgcgtt ccatgggagg accatgggtt gcttagcgac cacgcactct aaagccattc acaagatcga catcccttcc tttgactggc ccatcgcacc gttcccacgg ctgaaatacc ctctggaaga gtttgtgaaa gagaaccaac aggaggaggc ccgctgtctg gaagaggtgg aggatctgat tgtgaaatat cggaaaaaga agaagacggt ggccgggatc atcgtggagc ccatccagtc cgagggtgga gacaaccacg catccgatga cttctttcgg aagctgagag acatcgccag gaagcatggc tgcgccttct tggtggacga ggtccagacc ggaggaggct gcacgggcaa gttctgggcc catgagcact ggggcctgga tgacccagca gacgtgatga ccttcagcaa gaagatgatg actgggggct tcttccacaa ggaggagttc aggcctaatg ctccctaccg gatcttcaac acctggctgg gggacccgtc caagaacctg ttgctggctg aggtcatcaa catcatcaag cgggaggacc tgctaaataa tgcagcccat gccgggaagg ccctgctcac aggactgctg gacctccagg cccggtaccc ccagttcatc agcagggtga gaggacgagg caccttttgc tccttcgata ctcccgatga ttccatacgg aataagctca ttttaattgc cagaaacaaa ggtgtggtgt tgggtggctg tggtgacaaa tccattcgtt tccgtcccac gctggtcttc agggatcacc acgctcacct gttcctcaat attttcagtg acatcttagc agacttcaag taa

Molecular Weight

56,439 Da

OMIM

137150

Vector

pUC

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of ABAT cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ABAT. It may not necessarily be applicable to this product.

NCBI GI #

33874525

NCBI GeneID

NCBI Accession #

BC015628

UniProt Secondary Accession #

Q16260; Q8N5W2; Q96BG2; Q99800; A8K386

UniProt Related Accession #

P80404

NCBI Official Full Name

Homo sapiens 4-aminobutyrate aminotransferase, mRNA

NCBI Official Synonym Full Names

4-aminobutyrate aminotransferase

NCBI Official Symbol

ABAT

NCBI Official Synonym Symbols

GABAT; NPD009; GABA-AT

UniProt Protein Name

4-aminobutyrate aminotransferase, mitochondrial

UniProt Synonym Protein Names

(S)-3-amino-2-methylpropionate transaminase (EC:2.6.1.22); GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; GABA-T; L-AIBAT

UniProt Gene Name

ABAT

UniProt Synonym Gene Names

GABAT; GABA-AT; GABA transaminase; GABA-T

UniProt Entry Name

GABT_HUMAN

NCBI Protein Information

4-aminobutyrate aminotransferase, mitochondrial

NCBI Summary for ABAT

4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008]

UniProt Comments for ABAT

ABAT: Catalyzes the conversion of gamma-aminobutyrate and L- beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine. Defects in ABAT are a cause of GABA transaminase deficiency (GABATD). The phenotype of this deficiency includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

Protein type: Carbohydrate Metabolism - propanoate; Amino Acid Metabolism - alanine, aspartate and glutamate; Transferase; Mitochondrial; EC 2.6.1.19; EC 2.6.1.22; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Other Amino Acids Metabolism - beta-alanine; Carbohydrate Metabolism - butanoate

Chromosomal Location of Human Ortholog: 16p13.2

Cellular Component: 4-aminobutyrate transaminase complex; mitochondrial matrix; mitochondrion

Molecular Function: 4-aminobutyrate transaminase activity; protein homodimerization activity; pyridoxal phosphate binding; succinate-semialdehyde dehydrogenase binding

Biological Process: behavioral response to cocaine; gamma-aminobutyric acid catabolic process

Disease: Gaba-transaminase Deficiency

Research Articles on ABAT

1. This study utilized ER+ IBC to identify a metagene including ABAT and STC2 as predictive biomarkers for endocrine therapy resistance.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with ABAT cdna clone

Products by Pathway	Pathway Diagram
4-aminobutyrate Degradation I Pathway antibodies	4-aminobutyrate Degradation I Pathway Diagram
4-aminobutyrate Degradation I Pathway antibodies	4-aminobutyrate Degradation I Pathway Diagram
Alanine And Aspartate Metabolism Pathway antibodies	Alanine And Aspartate Metabolism Pathway Diagram
Alanine, Aspartate And Glutamate Metabolism Pathway antibodies	Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
Alanine, Aspartate And Glutamate Metabolism Pathway antibodies	Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
Butanoate Metabolism Pathway antibodies	Butanoate Metabolism Pathway Diagram
Butanoate Metabolism Pathway antibodies	Butanoate Metabolism Pathway Diagram
Degradation Of GABA Pathway antibodies	Degradation Of GABA Pathway Diagram
GABA (gamma-Aminobutyrate) Shunt Pathway antibodies	GABA (gamma-Aminobutyrate) Shunt Pathway Diagram
GABA (gamma-Aminobutyrate) Shunt Pathway antibodies	GABA (gamma-Aminobutyrate) Shunt Pathway Diagram

Diseases associated with ABAT cdna clone

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>5 publications with ABAT and Nervous System Diseases
Drug Toxicity Antibodies	>4 publications with ABAT and Drug Toxicity
Genetic Predisposition to Disease Antibodies	>4 publications with ABAT and Genetic Predisposition to Disease
Brain Diseases Antibodies	>3 publications with ABAT and Brain Diseases
Cardiovascular Diseases Antibodies	>3 publications with ABAT and Cardiovascular Diseases
Kidney Diseases Antibodies	>2 publications with ABAT and Kidney Diseases
Necrosis Antibodies	>2 publications with ABAT and Necrosis
Autistic Disorder Antibodies	>2 publications with ABAT and Autistic Disorder
Poisoning Antibodies	>1 publications with ABAT and Poisoning
Hypertension Antibodies	>1 publications with ABAT and Hypertension

Organs/Tissues associated with ABAT cdna clone

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>7 publications with ABAT and Brain
Bone Antibodies	>6 publications with ABAT and Bone
Blood Antibodies	>6 publications with ABAT and Blood
Liver Antibodies	>5 publications with ABAT and Liver
Muscle Antibodies	>2 publications with ABAT and Muscle
Kidney Antibodies	>2 publications with ABAT and Kidney
Heart Antibodies	>1 publications with ABAT and Heart
Lymph Antibodies	>1 publications with ABAT and Lymph
Lymph Node Antibodies	>1 publications with ABAT and Lymph Node
Skin Antibodies	>1 publications with ABAT and Skin