Human ABCB6 cDNA Clone Expression Plasmid – Cat# MBS1269188

ABCB6 cDNA Clone – ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 6 (Human)

Name: ABCB6 cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1269188
Price: 945 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1269188

MBS1269188 is a cDNA clone targeting ABCB6. More details

$945 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

ABCB6, cDNA Clone

Full Product Name

ABCB6 cDNA Clone

Product Gene Name

ABCB6 cdna clone

Sequence

atggtgactg tgggcaacta ctgcgaggcc gaagggcccg tgggtccggc ctggatgcag gatggcctga gtccctgctt cttcttcacg ctcgtgccct cgacgcggat ggctctaggg actctggcct tggtgctggc tcttccctgc agacgccggg agcggcccgc tggtgctgat tcgctgtctt ggggggccgg ccctcgcatc tctccctacg tgctgcagct gcttctggcc acacttcagg cggcgctgcc cctggccggc ctggctggcc gggtgggcac tgcccggggg gccccactgc caagctatct acttctggcc tccgtgctgg agagtctggc cggcgcctgt ggcctgtggc tgcttgtcgt ggagcggagc caggcacggc agcgtctggc aatgggcatc tggatcaagt tcaggcacag ccctggtctc ctgctcctct ggactgtggc gtttgcagct gagaacttgg ccctggtgtc ttggaacagc ccacagtggt ggtgggcaag ggcagacttg ggccagcagg ttcagtttag cctgtgggtg ctgcggtatg tggtctctgg agggctgttt gtcctgggtc tctgggcccc tggacttcgt ccccagtcct atacattgca ggttcatgaa gaggaccaag atgtggaaag gagccaggtt cggtcagcag cccaacagtc tacctggcga gattttggca ggaagctccg cctcctgagt ggctacctgt ggcctcgagg gagtccagct ctgcagctgg tggtgctcat ctgcctgggg ctcatgggtt tggaacgggc actcaatgtg ttggtgccta tattctatag gaacattgtg aacttgctga ctgagaaggc accttggaac tctctggcct ggactgttac cagttacgtc ttcctcaagt tcctccaggg gggtggcact ggcagtacag gcttcgtgag caacctgcgc accttcctgt ggatccgggt gcagcagttc acgtctcggc gggtggagct gctcatcttc tcccacctgc acgagctctc actgcgctgg cacctggggc gccgcacagg ggaggtgctg cggatcgcgg atcggggcac atccagtgtc acagggctgc tcagctacct ggtgttcaat gtcatcccca cgctggccga catcatcatt ggcatcatct acttcagcat gttcttcaac gcctggtttg gcctcattgt gttcctgtgc atgagtcttt acctcaccct gaccattgtg gtcactgagt ggagaaccaa gtttcgtcgt gctatgaaca cacaggagaa cgctacccgg gcacgagcag tggactctct gctaaacttc gagacggtga agtattacaa cgccgagagt tacgaagtgg aacgctatcg agaggccatc atcaaatatc agggtttgga gtggaagtcg agcgcttcac tggttttact aaatcagacc cagaacctgg taattgggct cgggctcctc gccggctccc tgctttgcgc atactttgtc actgagcaga agctacaggt tggggactat gtgctctttg gcacctacat tatccagctg tacatgcccc tcaattggtt tggcacctac tacaggatga tccagaccaa cttcattgac atggagaaca tgtttgactt gctgaaagag gagacagaag tgaaggacct tcctggagca gggccccttc gctttcagaa gggccgtatt gagtttgaga acgtgcactt cagctatgcc gatgggcggg agactctgca ggacgtgtct ttcactgtga tgcctggaca gacacttgcc ctggtgggcc catctggggc agggaagagc acaattttgc gcctgctgtt tcgcttctac gacatcagct ctggctgcat ccgaatagat gggcaggaca tttcacaggt gacccaggcc tctctccggt ctcacattgg agttgtgccc caagacactg tcctctttaa tgacaccatc gccgacaata tccgttacgg ccgtgtcaca gctgggaatg atgaggtgga ggctgctgct caggctgcag gcatccatga tgccattatg gctttccctg aagggtacag gacacaggtg ggcgagcggg gactgaagct gagcggcggg gagaagcagc gcgtcgccat tgcccgcacc atcctcaagg ctccgggcat cattctgctg gatgaggcaa cgtcagcgct ggatacatct aatgagaggg ccatccaggc ttctctggcc aaagtctgtg ccaaccgcac caccatcgta gtggcacaca ggctctcaac tgtggtcaat gctgaccaga tcctcgtcat caaggatggc tgcatcgtgg agaggggacg acacgaggct ctgttgtccc gaggtggggt gtatgctgac atgtggcagc tgcagcaggg acaggaagaa acctctgaag acactaagcc tcagaccatg gaacggtga

Molecular Weight

88,600 Da

OMIM

111600

Vector

Please Inquire

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of ABCB6 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ABCB6. It may not necessarily be applicable to this product.

NCBI GI #

33875571

NCBI GeneID

10058

NCBI Accession #

BC000559

UniProt Secondary Accession #

O75542; Q49A66; Q59GQ5; Q6ZME6; Q96ME8; Q9HAQ6; Q9HAQ7

UniProt Related Accession #

Q9NP58

NCBI Official Full Name

Homo sapiens ATP-binding cassette, sub-family B (MDR/TAP), member 6, mRNA

NCBI Official Synonym Full Names

ATP binding cassette subfamily B member 6 (Langereis blood group)

NCBI Official Symbol

ABCB6

NCBI Official Synonym Symbols

ABC; LAN; PRP; DUH3; umat; ABC14; PSHK2; MTABC3; MCOPCB7

UniProt Protein Name

ATP-binding cassette sub-family B member 6, mitochondrial

UniProt Synonym Protein Names

Mitochondrial ABC transporter 3; Mt-ABC transporter 3; P-glycoprotein-related protein; Ubiquitously-expressed mammalian ABC half transporter

Protein Family

ABC transporter B family

UniProt Gene Name

ABCB6

UniProt Synonym Gene Names

MTABC3; PRP; UMAT; Mt-ABC transporter 3

UniProt Entry Name

ABCB6_HUMAN

NCBI Protein Information

ATP-binding cassette sub-family B member 6, mitochondrial

NCBI Summary for ABCB6

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This half-transporter likely plays a role in mitochondrial function. Localized to 2q26, this gene is considered a candidate gene for lethal neonatal metabolic syndrome, a disorder of mitochondrial function. [provided by RefSeq, Jul 2008]

UniProt Comments for ABCB6

ABCB6: Binds heme and porphyrins and functions in their ATP- dependent uptake into the mitochondria. Plays a crucial role in heme synthesis. Defects in ABCB6 are the cause of microphthalmia, isolated, with coloboma, type 7 (MCOPCB7). A disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. Ocular abnormalities like opacities of the cornea and lens, scaring of the retina and choroid, cataract and other abnormalities like cataract may also be present. Ocular colobomas are a set of malformations resulting from abnormal morphogenesis of the optic cup and stalk, and the fusion of the fetal fissure (optic fissure). Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Mitochondrial; Membrane protein, multi-pass; Membrane protein, integral; Transporter, ABC family; Transporter; Hydrolase

Chromosomal Location of Human Ortholog: 2q36

Cellular Component: endoplasmic reticulum; endosome; Golgi apparatus; integral to mitochondrial outer membrane; mitochondrial envelope; mitochondrial inner membrane; mitochondrial outer membrane; mitochondrion; plasma membrane

Molecular Function: ATP binding; efflux transmembrane transporter activity; heme binding; heme transporter activity; heme-transporting ATPase activity

Biological Process: brain development; cellular iron ion homeostasis; heme transport; porphyrin biosynthetic process; skin development; transmembrane transport; transport

Disease: Blood Group, Langereis System; Dyschromatosis Universalis Hereditaria 3; Microphthalmia, Isolated, With Coloboma 7; Pseudohyperkalemia, Familial, 2, Due To Red Cell Leak

Research Articles on ABCB6

1. genetic variants linked to lower or absent cell surface expression of ABCB6/Langereis may be more common than previously thought.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with ABCB6 cdna clone

Products by Pathway	Pathway Diagram
ABC Transporters Pathway antibodies	ABC Transporters Pathway Diagram
ABC Transporters Pathway antibodies	ABC Transporters Pathway Diagram
ABC-family Proteins Mediated Transport Pathway antibodies	ABC-family Proteins Mediated Transport Pathway Diagram
Mitochondrial ABC Transporters Pathway antibodies	Mitochondrial ABC Transporters Pathway Diagram
Transmembrane Transport Of Small Molecules Pathway antibodies	Transmembrane Transport Of Small Molecules Pathway Diagram

Diseases associated with ABCB6 cdna clone

Disease Name	Pubmed Publications
Neoplasms Antibodies	>11 publications with ABCB6 and Neoplasms
Carcinoma Antibodies	>5 publications with ABCB6 and Carcinoma
Drug Toxicity Antibodies	>5 publications with ABCB6 and Drug Toxicity
Carcinoma, Hepatocellular Antibodies	>4 publications with ABCB6 and Carcinoma, Hepatocellular
Anemia Antibodies	>3 publications with ABCB6 and Anemia
Liver Neoplasms Antibodies	>3 publications with ABCB6 and Liver Neoplasms
Nervous System Diseases Antibodies	>3 publications with ABCB6 and Nervous System Diseases
Liver Diseases Antibodies	>3 publications with ABCB6 and Liver Diseases
Adenocarcinoma Antibodies	>3 publications with ABCB6 and Adenocarcinoma
Breast Neoplasms Antibodies	>2 publications with ABCB6 and Breast Neoplasms

Organs/Tissues associated with ABCB6 cdna clone

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>9 publications with ABCB6 and Liver
Blood Antibodies	>8 publications with ABCB6 and Blood
Brain Antibodies	>6 publications with ABCB6 and Brain
Lung Antibodies	>4 publications with ABCB6 and Lung
Skin Antibodies	>3 publications with ABCB6 and Skin
Intestine Antibodies	>1 publications with ABCB6 and Intestine
Bone Marrow Antibodies	>1 publications with ABCB6 and Bone Marrow
Eye Antibodies	>1 publications with ABCB6 and Eye
Testis Antibodies	>1 publications with ABCB6 and Testis
Bone Antibodies	>1 publications with ABCB6 and Bone