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ACSL1 cDNA Clone – Acyl-Coa Synthetase Long-Chain Family Member 1 (Human)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1270853

MBS1270853 is a cDNA clone targeting ACSL1. More details

$520 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
ACSL1, cDNA Clone
Full Product Name
ACSL1 cDNA Clone
Product Gene Name
ACSL1 cdna clone
Sequence
atgcaagccc atgagctgtt ccggtatttt cgaatgccag aactggttga cttccgacag tacgtgcgta ctcttccgac caacacgctt atgggcttcg gagcttttgc agcactcacc accttctggt acgccacgag acccaaaccc ctgaagccgc catgcgacct ctccatgcag tcagtggaag tggcgggtag tggtggtgca cgaagatccg cactacttga cagcgacgag cccttggtgt atttctatga tgatgtcaca acattatacg aaggtttcca gaggggaata caggtgtcaa ataatggccc ttgtttaggc tctcggaaac cagaccaacc ctatgaatgg ctttcatata aacaggttgc agaattgtcg gagtgcatag gctcagcact gatccagaag ggcttcaaga ctgccccaga tcagttcatt ggcatctttg ctcaaaatag acctgagtgg gtgattattg aacaaggatg ctttgcttat tcgatggtga tcgttccact ttatgatacc cttggaaatg aagccatcac gtacatagtc aacaaagctg aactctctct ggtttttgtt gacaagccag agaaggccaa actcttatta gagggtgtag aaaataagtt aataccaggc cttaaaatca tagttgtcat ggatgcctac ggcagtgaac tggtggaacg aggccagagg tgtggggtgg aagtcaccag catgaaggcg atggaggacc tgggaagagc caacagacgg aagcccaagc ctccagcacc tgaagatctt gcagtaattt gtttcacaag tggaactaca ggcaacccca aaggagcaat ggtcactcac cgaaacatag tgagcgattg ttcagctttt gtgaaagcaa cagagaatac agtcaatcct tgcccagatg atactttgat atctttcttg cctctcgccc atatgtttga gagagttgta gagtgtgtaa tgctgtgtca tggagctaaa atcggatttt tccaaggaga tatcaggctg ctcatggatg acctcaaggt gcttcaaccc actgtcttcc ccgtggttcc aagactgctg aaccggatgt ttgaccgaat tttcggacaa gcaaacacca cgctgaagcg atggctcttg gactttgcct ccaagaggaa agaagcagag cttcgcagcg gcatcatcag aaacaacagc ctgtgggacc ggctgatctt ccacaaagta cagtcgagcc tgggcggaag agtccggctg atggtgacag gagccgcccc ggtgtctgcc actgtgctga cgttcctcag agcagccctg ggctgtcagt tttatgaagg atacggacag acagagtgca ctgccgggtg ctgcctaacc atgcctggag actggaccgc aggccatgtt ggggccccga tgccgtgcaa tttgataaaa cttgttgatg tggaagaaat gaattacatg gctgccgagg gcgagggcga ggtgtgtgtg aaagggccaa atgtatttca gggctacttg aaggacccag cgaaaacagc agaagctttg gacaaagacg gctggttaca cacaggggac attggaaaat ggttaccaaa tggcaccttg aaaattatcg accggaaaaa gcacatattt aagctggcac aaggagaata catagcccct gaaaagattg aaaatatcta catgcgaagt gagcctgttg ctcaggtgtt tgtccacgga gaaagcctgc aggcatttct cattgcaatt gtggtaccag atgttgagac attatgttcc tgggcccaaa agagaggatt tgaagggtcg tttgaggaac tgtgcagaaa taaggatgtc aaaaaagcta tcctcgaaga tatggtgaga cttgggaagg attctggtct gaaaccattt gaacaggtca aaggcatcac attgcaccct gaattatttt ctatcgacaa tggccttctg actccaacaa tgaaggcgaa aaggccagag ctgcggaact atttcaggtc gcagatagat gacctctatt ccactatcaa ggtttag
Molecular Weight
77,907 Da
OMIM
152425
Vector
pENTR223.1 or pUC
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of ACSL1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ACSL1. It may not necessarily be applicable to this product.

NCBI GI #
29476794
NCBI GeneID
2180
NCBI Accession #
BC050073
UniProt Secondary Accession #
P41215; Q8N8V7; Q8TA99; B7Z452; D3DP57
UniProt Related Accession #
P33121
NCBI Official Full Name
Homo sapiens acyl-CoA synthetase long-chain family member 1, mRNA
NCBI Official Synonym Full Names
acyl-CoA synthetase long-chain family member 1
NCBI Official Symbol
ACSL1
NCBI Official Synonym Symbols
ACS1; LACS; FACL1; FACL2; LACS1; LACS2
UniProt Protein Name
Long-chain-fatty-acid--CoA ligase 1
UniProt Synonym Protein Names
Acyl-CoA synthetase 1; ACS1; Long-chain acyl-CoA synthetase 1; LACS 1; Long-chain acyl-CoA synthetase 2; LACS 2; Long-chain fatty acid-CoA ligase 2; Palmitoyl-CoA ligase 1; Palmitoyl-CoA ligase 2
Protein Family
Long-chain-fatty-acid--CoA ligase
UniProt Gene Name
ACSL1
UniProt Synonym Gene Names
FACL1; FACL2; LACS; LACS1; LACS2; ACS1; LACS 1; LACS 2
UniProt Entry Name
ACSL1_HUMAN
NCBI Protein Information
long-chain-fatty-acid--CoA ligase 1

NCBI Summary for ACSL1

The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
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UniProt Comments for ACSL1

ACSL1: Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitoleate, oleate and linoleate. Highly expressed in liver, heart, skeletal muscle, kidney and erythroid cells, and to a lesser extent in brain, lung, placenta and pancreas. Belongs to the ATP-dependent AMP-binding enzyme family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; EC 6.2.1.3; Ligase; Lipid Metabolism - fatty acid

Chromosomal Location of Human Ortholog: 4q35.1

Cellular Component: endoplasmic reticulum membrane; membrane; mitochondrial outer membrane; mitochondrion

Molecular Function: long-chain-fatty-acid-CoA ligase activity

Biological Process: linoleic acid metabolic process; lipid biosynthetic process; long-chain fatty acid metabolic process
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Research Articles on ACSL1

1. SRE motif in ACSL1 is essential for SREBP2-mediated activation of C-ACSL1 gene transcription.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with ACSL1 cdna clone

 Products by Pathway  Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Fatty Acid Beta Oxidation Pathway antibodies  Fatty Acid Beta Oxidation Pathway Diagram
 Fatty Acid Biosynthesis Pathway antibodies  Fatty Acid Biosynthesis Pathway Diagram
 Fatty Acyl-CoA Biosynthesis Pathway antibodies  Fatty Acyl-CoA Biosynthesis Pathway Diagram
 Fatty Acid Metabolism Pathway antibodies  Fatty Acid Metabolism Pathway Diagram
 Fatty Acid Metabolism Pathway antibodies  Fatty Acid Metabolism Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 Linoleic Acid (LA) Metabolism Pathway antibodies  Linoleic Acid (LA) Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram

Diseases associated with ACSL1 cdna clone

 Disease Name  Pubmed Publications
 Fatty Liver Antibodies  >15 publications with ACSL1 and Fatty Liver
 Obesity Antibodies  >13 publications with ACSL1 and Obesity
 Liver Diseases Antibodies  >9 publications with ACSL1 and Liver Diseases
 Inflammation Antibodies  >7 publications with ACSL1 and Inflammation
 Disease Models, Animal Antibodies  >4 publications with ACSL1 and Disease Models, Animal
 Atherosclerosis Antibodies  >4 publications with ACSL1 and Atherosclerosis
 Cardiovascular Diseases Antibodies  >4 publications with ACSL1 and Cardiovascular Diseases
 Neoplasms Antibodies  >4 publications with ACSL1 and Neoplasms
 Carcinoma Antibodies  >4 publications with ACSL1 and Carcinoma
 Liver Neoplasms Antibodies  >3 publications with ACSL1 and Liver Neoplasms

Organs/Tissues associated with ACSL1 cdna clone

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >22 publications with ACSL1 and Liver
 Adipose Tissue Antibodies  >12 publications with ACSL1 and Adipose Tissue
 Muscle Antibodies  >10 publications with ACSL1 and Muscle
 Blood Antibodies  >10 publications with ACSL1 and Blood
 Connective Tissue Antibodies  >8 publications with ACSL1 and Connective Tissue
 Heart Antibodies  >6 publications with ACSL1 and Heart
 Bone Antibodies  >4 publications with ACSL1 and Bone
 Bone Marrow Antibodies  >4 publications with ACSL1 and Bone Marrow
 Brain Antibodies  >4 publications with ACSL1 and Brain
 Mammary Gland Antibodies  >2 publications with ACSL1 and Mammary Gland
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