Human ACSL4 cDNA Clone Expression Plasmid – Cat# MBS1270741

ACSL4 cDNA Clone – Acyl-Coa Synthetase Long-Chain Family Member 4 (Human)

Name: ACSL4 cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1270741
Price: 520 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1270741

MBS1270741 is a cDNA clone targeting ACSL4. More details

$520 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

ACSL4, cDNA Clone

Full Product Name

ACSL4 cDNA Clone

Product Gene Name

ACSL4 cdna clone

Sequence

atggcaaaga gaataaaagc taagcccact tcagacaaac ctggaagtcc atatcgctct gtcacacact tcgactcact agctgtaata gacatccctg gagcagatac tctggataaa ttatttgacc atgctgtatc caagtttggg aagaaggaca gccttgggac cagggaaatc ctaagtgaag aaaatgaaat gcagccaaat ggaaaagttt ttaagaagtt aattcttggg aattataaat ggatgaacta tcttgaagtg aatcgcagag tgaataactt tggtagtgga ctcactgcac tgggactaaa accaaagaac accattgcca tcttctgtga gaccagggcc gaatggatga ttgcagcaca gacctgcttt aagtacaact ttcctcttgt gactttatat gccacacttg gcaaagaagc agtagttcat gggctaaatg aatctgaggc ttcctatctg attaccagtg ttgaacttct ggaaagtaaa cttaagactg cattgttaga tatcagttgt gttaaacata tcatttatgt ggacaataag gctatcaata aagcagagta ccctgaagga tttgagattc acagcatgca atcagtagaa gagttgggat ctaacccaga aaacttgggc attcctccaa gtagaccaac gccttcagac atggccattg ttatgtatac tagtggttct actggccgac ctaagggagt gatgatgcat catagcaatt tgatagctgg aatgacaggc cagtgtgaaa gaatacctgg actgggaccg aaggacacat atattggcta cttgcctttg gctcatgtgc tagaactgac agcagagata tcttgcttta cctatggctg caggattgga tattcttctc cgcttacact ctctgaccag tccagcaaaa ttaaaaaagg aagcaaagga gactgtactg tactgaagcc cacacttatg gctgctgttc cggaaatcat ggatagaatt tataagaatg ttatgagcaa agtccaagag atgaattata ttcagaaaac tctgttcaag atagggtatg attacaaatt ggaacagatc aaaaagggat atgatgcacc tctttgcaat ctgttactgt ttaaaaaggt caaggccctg ctgggaggga atgtccgcat gatgctgtct ggaggggccc cgctatctcc tcagacacac cgattcatga atgtctgctt ctgctgccca attggccagg gttatggact gacagaatca tgtggtgctg ggacagttac tgaagtaact gactatacta ctggcagagt tggagcacct cttatttgct gtgaaattaa gctaaaagac tggcaagaag gcggttatac aattaatgac aagccaaacc ccagaggtga aatcgtaatt ggtggacaga acatctccat gggatatttt aaaaatgaag agaaaacagc agaagattat tctgtggatg aaaatggaca aaggtggttt tgcactggtg atattggaga attccatccc gatggatgtt tacagattat agatcgtaag aaagatctag tgaagttaca agcaggagag tatgtatctc ttgggaaagt ggaagctgca ctgaagaatt gtccacttat tgacaacatc tgtgcttttg ccaaaagtga tcagtcctat gtgatcagtt ttgtggttcc taaccagaaa aggttgacac ttttggcaca acagaaaggg gtagaaggaa cttgggttga tatctgcaat aatcctgcta tggaagctga aatactgaaa gaaattcgag aagctgcaaa tgccatgaaa ttggagcgat ttgaaattcc aatcaaggtt cgattaagcc cagagccatg gacccctgaa actggtttgg taactgatgc tttcaaactg aaaaggaagg agctgaggaa ccattacctc aaagacattg aacgaatgta tgggggcaaa taa

Molecular Weight

74,436 Da

OMIM

300157

Vector

pENTR223.1 or pUC

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of ACSL4 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ACSL4. It may not necessarily be applicable to this product.

NCBI GI #

34194222

NCBI GeneID

2182

NCBI Accession #

BC034959

UniProt Secondary Accession #

O60848; O60849; Q5JWV8; D3DUY2

UniProt Related Accession #

O60488

NCBI Official Full Name

Homo sapiens acyl-CoA synthetase long-chain family member 4, mRNA

NCBI Official Synonym Full Names

acyl-CoA synthetase long-chain family member 4

NCBI Official Symbol

ACSL4

NCBI Official Synonym Symbols

ACS4; FACL4; LACS4; MRX63; MRX68

UniProt Protein Name

Long-chain-fatty-acid--CoA ligase 4

UniProt Synonym Protein Names

Long-chain acyl-CoA synthetase 4; LACS 4

UniProt Gene Name

ACSL4

UniProt Synonym Gene Names

ACS4; FACL4; LACS4; LACS 4

UniProt Entry Name

ACSL4_HUMAN

NCBI Protein Information

long-chain-fatty-acid--CoA ligase 4

NCBI Summary for ACSL4

The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme preferentially utilizes arachidonate as substrate. The absence of this enzyme may contribute to the mental retardation or Alport syndrome. Alternative splicing of this gene generates multiple transcript variants. [provided by RefSeq, Jan 2016]

UniProt Comments for ACSL4

ACSL4: Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses arachidonate and eicosapentaenoate as substrates. Defects in ACSL4 are the cause of mental retardation X- linked type 63 (MRX63). Mental retardation is a mental disorder characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non- syndromic mental retardation patients do not manifest other clinical signs. Defects in ACSL4 are involved in Alport syndrome with mental retardation midface hypoplasia and elliptocytosis (ATS-MR). A X-linked contiguous gene deletion syndrome characterized by glomerulonephritis, deafness, mental retardation, midface hypoplasia and elliptocytosis. Belongs to the ATP-dependent AMP-binding enzyme family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Lipid Metabolism - fatty acid; Membrane protein, integral; Ligase; EC 6.2.1.3

Chromosomal Location of Human Ortholog: Xq22.3-q23

Cellular Component: cytoplasm; endoplasmic reticulum membrane; lipid particle; membrane

Molecular Function: arachidonate-CoA ligase activity; long-chain-fatty-acid-CoA ligase activity; very-long-chain-fatty-acid-CoA ligase activity

Biological Process: lipid metabolic process

Disease: Mental Retardation, X-linked 63

Research Articles on ACSL4

1. In vitro analysis showed that a recombinant COX-2 enzyme more effectively metabolized 5(S)-HETE to 5-11-diHETE compared to COX-1 enzyme.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with ACSL4 cdna clone

Products by Pathway	Pathway Diagram
Adipocytokine Signaling Pathway antibodies	Adipocytokine Signaling Pathway Diagram
Adipocytokine Signaling Pathway antibodies	Adipocytokine Signaling Pathway Diagram
Fatty Acid Beta Oxidation Pathway antibodies	Fatty Acid Beta Oxidation Pathway Diagram
Fatty Acid Biosynthesis Pathway antibodies	Fatty Acid Biosynthesis Pathway Diagram
Fatty Acyl-CoA Biosynthesis Pathway antibodies	Fatty Acyl-CoA Biosynthesis Pathway Diagram
Fatty Acid Metabolism Pathway antibodies	Fatty Acid Metabolism Pathway Diagram
Fatty Acid Metabolism Pathway antibodies	Fatty Acid Metabolism Pathway Diagram
Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies	Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Metabolism Of Lipids And Lipoproteins Pathway antibodies	Metabolism Of Lipids And Lipoproteins Pathway Diagram

Diseases associated with ACSL4 cdna clone

Disease Name	Pubmed Publications
Fatty Liver Antibodies	>9 publications with ACSL4 and Fatty Liver
Nervous System Diseases Antibodies	>7 publications with ACSL4 and Nervous System Diseases
Neoplasms Antibodies	>3 publications with ACSL4 and Neoplasms
Liver Diseases Antibodies	>3 publications with ACSL4 and Liver Diseases
Abnormalities, Multiple Antibodies	>2 publications with ACSL4 and Abnormalities, Multiple
Carcinoma, Hepatocellular Antibodies	>2 publications with ACSL4 and Carcinoma, Hepatocellular
Atherosclerosis Antibodies	>1 publications with ACSL4 and Atherosclerosis
Brain Diseases Antibodies	>1 publications with ACSL4 and Brain Diseases
Kidney Diseases Antibodies	>1 publications with ACSL4 and Kidney Diseases
Inflammation Antibodies	>1 publications with ACSL4 and Inflammation