Human ACTA1 cDNA Clone Expression Plasmid – Cat# MBS1268002

ACTA1 cDNA Clone – Actin, Alpha 1, Skeletal Muscle (Human)

Name: ACTA1 cDNA Clone; Actin, Alpha 1, Skeletal Muscle; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1268002
Price: 235 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1268002

MBS1268002 is a cDNA clone targeting ACTA1. More details

$235 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

ACTA1, cDNA Clone

Full Product Name

ACTA1 cDNA Clone

Product Gene Name

ACTA1 cdna clone

Sequence

atgtgcgacg aagacgagac caccgccctc gtgtgcgaca atggctccgg cctggtgaaa gccggcttcg ccggggatga cgcccctagg gccgtgttcc cgtccatcgt gggccgcccc cgacaccagg gcgtcatggt cggtatgggt cagaaagatt cctacgtggg cgacgaggct cagagcaaga gaggtatcct gaccctgaag taccctatcg agcacggcat catcaccaac tgggatgaca tggagaagat ctggcaccac accttctaca acgagcttcg cgtggctccc gaggagcacc ccaccctgct caccgaggcc cccctcaatc ccaaggccaa ccgcgagaag atgacccaga tcatgtttga gaccttcaac gtgcccgcca tgtacgtggc catccaggcc gtgctgtccc tctacgcctc cggcaggacc accggcatcg tgctggactc cggcgacggc gtcacccaca acgtgcccat ttatgagggc tacgcgctgc cgcacgccat catgcgcctg gacctggcgg gccgcgatct caccgactac ctgatgaaga tcctcactga gcgtggctac tccttcgtga ccacagctga gcgcgagatc gtgcgcgaca tcaaggagaa gctgtgctac gtggccctgg acttcgagaa cgagatggcg acggccgcct cctcctcctc cctggaaaag agctacgagc tgccagacgg gcaggtcatc accatcggca acgagcgctt ccgctgcccg gagacgctct tccagccctc cttcatcggt atggagtcgg cgggcattca cgagaccacc tacaacagca tcatgaagtg tgacatcgac atcaggaagg acctgtatgc caacaacgtc atgtcggggg gcaccacgat gtaccctggg atcgctgacc gcatgcagaa agagatcacc gcgctggcac ccagcaccat gaagatcaag atcatcgccc cgccggagcg caaatactcg gtgtggatcg gcggctccat cctggcctcg ctgtccacct tccagcagat gtggatcacc aagcaggagt acgacgaggc cggcccttcc atcgtccacc gcaaatgctt ctag

Molecular Weight

42,051 Da

OMIM

102610

Vector

pENTR223.1 or pUC

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of ACTA1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ACTA1. It may not necessarily be applicable to this product.

NCBI GI #

15214922

NCBI GeneID

NCBI Accession #

BC012597

UniProt Secondary Accession #

P02568; P99020; Q5T8M9

UniProt Related Accession #

P68133

NCBI Official Full Name

Homo sapiens actin, alpha 1, skeletal muscle, mRNA

NCBI Official Synonym Full Names

actin, alpha 1, skeletal muscle

NCBI Official Symbol

ACTA1

NCBI Official Synonym Symbols

ACTA; ASMA; CFTD; MPFD; NEM1; NEM2; NEM3; SHPM; CFTD1; CFTDM

UniProt Protein Name

Actin, alpha skeletal muscle

UniProt Synonym Protein Names

Alpha-actin-1

UniProt Gene Name

ACTA1

UniProt Synonym Gene Names

ACTA

UniProt Entry Name

ACTS_HUMAN

NCBI Protein Information

actin, alpha skeletal muscle

NCBI Summary for ACTA1

The product encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Mutations in this gene cause nemaline myopathy type 3, congenital myopathy with excess of thin myofilaments, congenital myopathy with cores, and congenital myopathy with fiber-type disproportion, diseases that lead to muscle fiber defects. [provided by RefSeq, Jul 2008]

UniProt Comments for ACTA1

ACTA1: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Interacts with TTID. Interacts (via its C-terminus) with USP25; the interaction occurs for all USP25 isoforms but is strongest for isoform USP25m in muscle differentiating cells. Belongs to the actin family.

Protein type: Contractile; Motility/polarity/chemotaxis; Cytoskeletal; Cell development/differentiation

Chromosomal Location of Human Ortholog: 1q42.13

Cellular Component: actin cytoskeleton; actin filament; cytosol; extracellular space; filopodium; lamellipodium; sarcomere; stress fiber; striated muscle thin filament

Molecular Function: ADP binding; ATP binding; myosin binding; protein binding; structural constituent of cytoskeleton

Biological Process: muscle contraction; muscle filament sliding; muscle thin filament assembly; skeletal muscle fiber development

Disease: Myopathy, Congenital, With Fiber-type Disproportion; Myopathy, Scapulohumeroperoneal; Nemaline Myopathy 3

Research Articles on ACTA1

1. Upon actin engagement, the N-terminal "strap" and helix 1 are displaced from the vinculin tail helical bundle to mediate actin bundling.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with ACTA1 cdna clone

Products by Pathway	Pathway Diagram
Caspase Cascade In Apoptosis Pathway antibodies	Caspase Cascade In Apoptosis Pathway Diagram
Hypothetical Network For Drug Addiction Pathway antibodies	Hypothetical Network For Drug Addiction Pathway Diagram
Myometrial Relaxation And Contraction Pathways antibodies	Myometrial Relaxation And Contraction Pathways Diagram
RhoA Signaling Pathway antibodies	RhoA Signaling Pathway Diagram
Signaling Events Mediated By Focal Adhesion Kinase Pathway antibodies	Signaling Events Mediated By Focal Adhesion Kinase Pathway Diagram
Striated Muscle Contraction Pathway antibodies	Striated Muscle Contraction Pathway Diagram

Diseases associated with ACTA1 cdna clone

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>72 publications with ACTA1 and Nervous System Diseases
MYOPATHY, CONGENITAL, WITH FIBER-TYPE DISPROPORTION Antibodies	>56 publications with ACTA1 and MYOPATHY, CONGENITAL, WITH FIBER-TYPE DISPROPORTION
Nemaline myopathy 3 Antibodies	>15 publications with ACTA1 and Nemaline myopathy 3
Hypertrophy Antibodies	>13 publications with ACTA1 and Hypertrophy
Heart Diseases Antibodies	>13 publications with ACTA1 and Heart Diseases
Cardiovascular Diseases Antibodies	>11 publications with ACTA1 and Cardiovascular Diseases
Cardiomegaly Antibodies	>5 publications with ACTA1 and Cardiomegaly
Fibrosis Antibodies	>5 publications with ACTA1 and Fibrosis
Hepatomegaly Antibodies	>2 publications with ACTA1 and Hepatomegaly
Prenatal Exposure Delayed Effects Antibodies	>2 publications with ACTA1 and Prenatal Exposure Delayed Effects

Organs/Tissues associated with ACTA1 cdna clone

Organ/Tissue Name	Pubmed Publications
Muscle Antibodies	>106 publications with ACTA1 and Muscle
Heart Antibodies	>20 publications with ACTA1 and Heart
Brain Antibodies	>9 publications with ACTA1 and Brain
Embryonic Tissue Antibodies	>6 publications with ACTA1 and Embryonic Tissue
Bone Antibodies	>4 publications with ACTA1 and Bone
Nerve Antibodies	>3 publications with ACTA1 and Nerve
Lung Antibodies	>3 publications with ACTA1 and Lung
Eye Antibodies	>2 publications with ACTA1 and Eye
Kidney Antibodies	>2 publications with ACTA1 and Kidney
Adipose Tissue Antibodies	>1 publications with ACTA1 and Adipose Tissue