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ACTA2 cDNA Clone – Actin, Alpha 2, Smooth Muscle, Aorta (Human)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1268151

MBS1268151 is a cDNA clone targeting ACTA2. More details

$235 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
ACTA2, cDNA Clone
Full Product Name
ACTA2 cDNA Clone
Product Gene Name
ACTA2 cdna clone
Sequence
atgtgtgaag aagaggacag cactgccttg gtgtgtgaca atggctctgg gctctgtaag gccggctttg ctggggacga tgctcccagg gctgttttcc catccattgt gggacgtccc agacatcagg gggtgatggt gggaatggga caaaaagaca gctacgtggg tgacgaagca cagagcaaaa gaggaatcct gaccctgaag tacccgatag aacatggcat catcaccaac tgggacgaca tggaaaagat ctggcaccac tctttctaca atgagcttcg tgttgcccct gaagagcatc ccaccctgct cacggaggca cccctgaacc ccaaggccaa ccgggagaaa atgactcaaa ttatgtttga gactttcaat gtcccagcca tgtatgtggc tatccaggcg gtgctgtctc tctatgcctc tggacgcaca actggcatcg tgctggactc tggagatggt gtcacccaca atgtccccat ctatgagggc tatgccttgc cccatgccat catgcgtctg gatctggctg gccgagatct cactgactac ctcatgaaga tcctgactga gcgtggctat tccttcgtta ctactgctga gcgtgagatt gtccgggaca tcaaggagaa actgtgttat gtagctctgg actttgaaaa tgagatggcc actgccgcat cctcatcctc ccttgagaag agttacgagt tgcctgatgg gcaagtgatc accatcggaa atgaacgttt ccgctgccca gagaccctgt tccagccatc cttcatcggg atggagtctg ctggcatcca tgaaaccacc tacaacagca tcatgaagtg tgatattgac atcaggaagg acctctatgc taacaatgtc ctatcagggg gcaccactat gtaccctggc attgccgacc gaatgcagaa ggagatcacg gccctagcac ccagcaccat gaagatcaag atcattgccc ctccggagcg caaatactct gtctggatcg gtggctccat cctggcctct ctgtccacct tccagcagat gtggatcagc aaacaggaat acgatgaagc cgggccttcc attgtccacc gcaaatgctt ctaa
Molecular Weight
42,009 Da
OMIM
102620
Vector
pENTR223.1
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of ACTA2 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ACTA2. It may not necessarily be applicable to this product.

NCBI GI #
34189298
NCBI GeneID
59
NCBI Accession #
BC017554
UniProt Secondary Accession #
P03996; P04108; Q6FI19; B2R8A4
UniProt Related Accession #
P62736
NCBI Official Full Name
Homo sapiens actin, alpha 2, smooth muscle, aorta, mRNA
NCBI Official Synonym Full Names
actin, alpha 2, smooth muscle, aorta
NCBI Official Symbol
ACTA2
NCBI Official Synonym Symbols
AAT6; ACTSA; MYMY5
UniProt Protein Name
Actin, aortic smooth muscle
UniProt Synonym Protein Names
Alpha-actin-2; Cell growth-inhibiting gene 46 protein
Protein Family
Actin
UniProt Gene Name
ACTA2
UniProt Synonym Gene Names
ACTSA; ACTVS
UniProt Entry Name
ACTA_HUMAN
NCBI Protein Information
actin, aortic smooth muscle

NCBI Summary for ACTA2

The protein encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Defects in this gene cause aortic aneurysm familial thoracic type 6. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2008]
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UniProt Comments for ACTA2

ACTA2: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Up-regulated in response to enterovirus 71 (EV71) infection. Belongs to the actin family.

Protein type: Motility/polarity/chemotaxis; Contractile; Cytoskeletal

Chromosomal Location of Human Ortholog: 10q23.3

Cellular Component: cytoplasm; cytosol; extracellular space; filopodium; lamellipodium; protein complex

Molecular Function: protein kinase binding

Biological Process: muscle contraction; response to virus

Disease: Aortic Aneurysm, Familial Thoracic 6; Moyamoya Disease 5; Multisystemic Smooth Muscle Dysfunction Syndrome
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Research Articles on ACTA2

1. alpha-SMA expression, and MLC phosphorylation, whereas butaprost inhibited TGF-beta2-induced CPCG contraction, actin polymerization, and MLC phosphorylation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with ACTA2 cdna clone

 Products by Pathway  Pathway Diagram
 Muscle Contraction Pathway antibodies  Muscle Contraction Pathway Diagram
 Myometrial Relaxation And Contraction Pathways antibodies  Myometrial Relaxation And Contraction Pathways Diagram
 Smooth Muscle Contraction Pathway antibodies  Smooth Muscle Contraction Pathway Diagram
 Striated Muscle Contraction Pathway antibodies  Striated Muscle Contraction Pathway Diagram
 Vascular Smooth Muscle Contraction Pathway antibodies  Vascular Smooth Muscle Contraction Pathway Diagram
 Vascular Smooth Muscle Contraction Pathway antibodies  Vascular Smooth Muscle Contraction Pathway Diagram

Diseases associated with ACTA2 cdna clone

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >156 publications with ACTA2 and Neoplasms
 Fibrosis Antibodies  >137 publications with ACTA2 and Fibrosis
 Inflammation Antibodies  >39 publications with ACTA2 and Inflammation
 Disease Models, Animal Antibodies  >34 publications with ACTA2 and Disease Models, Animal
 Liver Diseases Antibodies  >34 publications with ACTA2 and Liver Diseases
 Kidney Diseases Antibodies  >30 publications with ACTA2 and Kidney Diseases
 Heart Diseases Antibodies  >26 publications with ACTA2 and Heart Diseases
 Breast Neoplasms Antibodies  >23 publications with ACTA2 and Breast Neoplasms
 Liver Cirrhosis Antibodies  >23 publications with ACTA2 and Liver Cirrhosis
 Aortic Aneurysm, Thoracic Antibodies  >22 publications with ACTA2 and Aortic Aneurysm, Thoracic

Organs/Tissues associated with ACTA2 cdna clone

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >409 publications with ACTA2 and Muscle
 Vascular Antibodies  >131 publications with ACTA2 and Vascular
 Blood Antibodies  >91 publications with ACTA2 and Blood
 Eye Antibodies  >82 publications with ACTA2 and Eye
 Connective Tissue Antibodies  >67 publications with ACTA2 and Connective Tissue
 Lung Antibodies  >64 publications with ACTA2 and Lung
 Kidney Antibodies  >51 publications with ACTA2 and Kidney
 Liver Antibodies  >48 publications with ACTA2 and Liver
 Skin Antibodies  >39 publications with ACTA2 and Skin
 Embryonic Tissue Antibodies  >38 publications with ACTA2 and Embryonic Tissue
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