Human AGPAT2 cDNA Clone Expression Plasmid – Cat# MBS1271510

AGPAT2 cDNA Clone – 1-Acylglycerol-3-Phosphate O-Acyltransferase 2 (Lysophosphatidic Acid Acyltransferase, Beta) (Human)

Name: AGPAT2 cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1271510
Price: 360 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1271510

MBS1271510 is a cDNA clone targeting AGPAT2. More details

$360 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

AGPAT2, cDNA Clone

Full Product Name

AGPAT2 cDNA Clone

Product Gene Name

AGPAT2 cdna clone

Sequence

atggagctgt ggccgtgtct ggccgcggcg ctgctgttgc tgctgctgct ggtgcagctg agccgcgcgg ccgagttcta cgccaaggtc gccctgtact gcgcgctgtg cttcacggtg tccgccgtgg cctcgctcgt ctgcctgctg cgccacggcg gccggacggt ggagaacatg agcatcatcg gctggttcgt gcgaagcttc aagtactttt acgggctccg cttcgaggtg cgggacccgc gcaggctgca ggaggcccgt ccctgtgtca tcgtctccaa ccaccagagc atcctggaca tgatgggcct catggaggtc cttccggagc gctgcgtgca gatcgccaag cgggagctgc tcttcctggg gcccgtgggc ctcatcatgt acctcggggg cgtcttcttc atcaaccggc agcgctctag cactgccatg acagtgatgg ccgacctggg cgagcgcatg gtcagggaga acctcaaagt gtggatctat cccgagggta ctcgcaacga caatggggac ctgctgcctt ttaagaaggg cgccttctac ctggcagtcc aggcacaggt gcccatcttc cccgtggtgt actcttcctt ctcctccttc tacaacacca agaagaagtt cttcacttca ggaacagtca cagtgcaggt gctggaagcc atccccacca gcggcctcac tgcggcggac gtccctgcgc tcgtggacac ctgccaccgg gccatgagga ccaccttcct ccacatctcc aagacccccc aggagaacgg ggccactgcg gggtctggcg tgcagccggc ccagtag

Molecular Weight

27,279 Da

OMIM

603100

Vector

Please Inquire

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of AGPAT2 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for AGPAT2. It may not necessarily be applicable to this product.

NCBI GI #

34783031

NCBI GeneID

10555

NCBI Accession #

BC000026

UniProt Secondary Accession #

O00516; O15106; Q5VUD3; Q5VUD4; Q9BSV7; Q9BWR7

UniProt Related Accession #

O15120

NCBI Official Full Name

Homo sapiens 1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta), mRNA

NCBI Official Synonym Full Names

1-acylglycerol-3-phosphate O-acyltransferase 2

NCBI Official Symbol

AGPAT2

NCBI Official Synonym Symbols

BSCL; BSCL1; LPAAB; 1-AGPAT2; LPAAT-beta

UniProt Protein Name

1-acyl-sn-glycerol-3-phosphate acyltransferase beta

UniProt Synonym Protein Names

1-acylglycerol-3-phosphate O-acyltransferase 2; 1-AGP acyltransferase 2; 1-AGPAT 2; Lysophosphatidic acid acyltransferase beta; LPAAT-beta

Protein Family

1-acyl-sn-glycerol-3-phosphate acyltransferase

UniProt Gene Name

AGPAT2

UniProt Synonym Gene Names

1-AGP acyltransferase 2; 1-AGPAT 2; LPAAT-beta

UniProt Entry Name

PLCB_HUMAN

NCBI Protein Information

1-acyl-sn-glycerol-3-phosphate acyltransferase beta

NCBI Summary for AGPAT2

This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. The protein is located within the endoplasmic reticulum membrane and converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. Mutations in this gene have been associated with congenital generalized lipodystrophy (CGL), or Berardinelli-Seip syndrome, a disease characterized by a near absence of adipose tissue and severe insulin resistance. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

UniProt Comments for AGPAT2

AGPAT2: Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Defects in AGPAT2 are the cause of congenital generalized lipodystrophy type 1 (CGL1); also known as Berardinelli-Seip congenital lipodystrophy type 1 (BSCL1) or Berardinelli-Seip syndrome. CGL1 is an autosomal recessive disorder characterized by marked paucity of adipose tissue, extreme insulin resistance, hypertriglyceridemia, hepatic steatosis and early onset of diabetes. Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Lipid Metabolism - glycerolipid; Lipid Metabolism - ether lipid; EC 2.3.1.51; Transferase; Membrane protein, integral; Membrane protein, multi-pass; Lipid Metabolism - glycerophospholipid

Chromosomal Location of Human Ortholog: 9q34.3

Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane

Molecular Function: 1-acylglycerol-3-phosphate O-acyltransferase activity

Biological Process: phosphatidic acid biosynthetic process; positive regulation of cytokine and chemokine mediated signaling pathway; positive regulation of cytokine production; triacylglycerol biosynthetic process

Disease: Lipodystrophy, Congenital Generalized, Type 1

Research Articles on AGPAT2

1. Data show that missense mutation c.299G>A changes serine in the acyltransferase NHX4D motif of AGPAT2, and intronic c.493-1G>C mutation destroy a splicing site that leads to exon 4 skipping and deletion of whole AGPAT2 substrate binding domain.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with AGPAT2 cdna clone

Products by Pathway	Pathway Diagram
Adipogenesis Pathway antibodies	Adipogenesis Pathway Diagram
CDP-diacylglycerol Biosynthesis I Pathway antibodies	CDP-diacylglycerol Biosynthesis I Pathway Diagram
CDP-diacylglycerol Biosynthesis I Pathway antibodies	CDP-diacylglycerol Biosynthesis I Pathway Diagram
Fat Digestion And Absorption Pathway antibodies	Fat Digestion And Absorption Pathway Diagram
Fat Digestion And Absorption Pathway antibodies	Fat Digestion And Absorption Pathway Diagram
Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies	Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
Glycerolipid Metabolism Pathway antibodies	Glycerolipid Metabolism Pathway Diagram
Glycerolipid Metabolism Pathway antibodies	Glycerolipid Metabolism Pathway Diagram
Glycerophospholipid Biosynthesis Pathway antibodies	Glycerophospholipid Biosynthesis Pathway Diagram
Glycerophospholipid Metabolism Pathway antibodies	Glycerophospholipid Metabolism Pathway Diagram

Diseases associated with AGPAT2 cdna clone

Disease Name	Pubmed Publications
LIPODYSTROPHY, CONGENITAL GENERALIZED, TYPE 1 Antibodies	>43 publications with AGPAT2 and LIPODYSTROPHY, CONGENITAL GENERALIZED, TYPE 1
Liver Diseases Antibodies	>11 publications with AGPAT2 and Liver Diseases
Hypertrophy Antibodies	>11 publications with AGPAT2 and Hypertrophy
Congenital Abnormalities Antibodies	>8 publications with AGPAT2 and Congenital Abnormalities
Hepatomegaly Antibodies	>5 publications with AGPAT2 and Hepatomegaly
Kidney Diseases Antibodies	>4 publications with AGPAT2 and Kidney Diseases
Heart Diseases Antibodies	>4 publications with AGPAT2 and Heart Diseases
Neoplasms Antibodies	>4 publications with AGPAT2 and Neoplasms
Fatty Liver Antibodies	>4 publications with AGPAT2 and Fatty Liver
Death Antibodies	>3 publications with AGPAT2 and Death

Organs/Tissues associated with AGPAT2 cdna clone

Organ/Tissue Name	Pubmed Publications
Adipose Tissue Antibodies	>37 publications with AGPAT2 and Adipose Tissue
Blood Antibodies	>13 publications with AGPAT2 and Blood
Connective Tissue Antibodies	>13 publications with AGPAT2 and Connective Tissue
Liver Antibodies	>13 publications with AGPAT2 and Liver
Muscle Antibodies	>12 publications with AGPAT2 and Muscle
Kidney Antibodies	>5 publications with AGPAT2 and Kidney
Bone Antibodies	>5 publications with AGPAT2 and Bone
Ovary Antibodies	>4 publications with AGPAT2 and Ovary
Skin Antibodies	>3 publications with AGPAT2 and Skin
Heart Antibodies	>3 publications with AGPAT2 and Heart