• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

ALG3 cDNA Clone – Asparagine-Linked Glycosylation 3, Alpha-1,3- Mannosyltransferase Homolog (S. Cerevisiae) (Human)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1265912

MBS1265912 is a cDNA clone targeting ALG3. More details

$235 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
ALG3, cDNA Clone
Full Product Name
ALG3 cDNA Clone
Product Gene Name
ALG3 cdna clone
Sequence
atggcggctg ggctgcggaa acgcggccgg tccggttccg cggcccaggc agagggactc tgcaagcaat ggctgcagcg cgcctggcaa gagcggcgcc tgctgctgcg ggagccgcgc tacacgctgc tggtggccgc ctgcctctgc ctggcggagg tgggcatcac cttctgggtc attcacaggg tggcatacac agagattgac tggaaggcct acatggccga ggtagaaggc gtcatcaatg gtacctatga ctatacccaa ctgcagggtg acaccggacc acttgtgtac ccagctggtt tcgtgtacat ctttatgggg ttgtactatg ccaccagccg aggcactgac atccgcatgg cccagaacat ctttgctgtg ctctacctgg ctaccttgct gcttgtcttc ttgatctatc accagacctg caaggtacct cccttcgtct ttttcttcat gtgctgcgcc tcttaccgtg tccactccat ctttgtgctg cggctcttca atgacccagt ggccatggtg ctgctcttcc tcagtatcaa cctcctgctg gcccagcgct ggggctgggg ttgctgcttt ttcagcctgg cagtctctgt gaagatgaat gtgctgctct tcgcccctgg gttactgttt cttctcctca cacagtttgg cttccgtggg gccctcccca agctgggaat ctgtgctggc cttcaggtgg tgctggggct gcccttcctg ctggagaacc ccagcggcta cctgtcccgc tcctttgacc ttggccgcca gtttctgttc cactggacag tgaactggcg cttcctccca gaggcgctct tcctgcatcg agccttccac ctggccctgt tgactgccca cctcaccctg ctcctgctgt ttgccctctg caggtggcac aggacagggg aaagtatctt gtcgctgctg agggatccct ccaaaaggaa ggttccaccc cagcccctta cacccaacca gatcgtttct accctcttca cctccaactt cattggcatc tgcttcagcc gctccctcca ctaccagttc tacgtctggt atttccacac actgccctac ctcctgtggg ccatgcctgc acgctggctc acacacctgc tcaggttgtt ggtgctgggg ctcatcgagc tctcctggaa cacataccct tccacatcct gcagctctgc tgccctgcac atatgccatg ccgtcatcct gctgcagctc tggctgggcc cgcagccttt ccccaagagc acccaacaca gcaagaaagc ccactga
Molecular Weight
44,370 Da
OMIM
601110
Vector
pENTR223.1 or pUC
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of ALG3 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ALG3. It may not necessarily be applicable to this product.

NCBI GI #
38114806
NCBI GeneID
10195
NCBI Accession #
BC002839
UniProt Secondary Accession #
Q9BT71; A8JZZ6
UniProt Related Accession #
Q92685
NCBI Official Full Name
Homo sapiens asparagine-linked glycosylation 3, alpha-1,3- mannosyltransferase homolog (S. cerevisiae), mRNA
NCBI Official Synonym Full Names
ALG3, alpha-1,3- mannosyltransferase
NCBI Official Symbol
ALG3
NCBI Official Synonym Symbols
not; CDG1D; CDGS4; CDGS6; Not56; NOT56L; D16Ertd36e
UniProt Protein Name
Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase
UniProt Synonym Protein Names
Asparagine-linked glycosylation protein 3 homolog; Dol-P-Man-dependent alpha(1-3)-mannosyltransferase; Dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase; Dolichyl-phosphate-mannose--glycolipid alpha-mannosyltransferase; Not56-like protein
Protein Family
Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase
UniProt Gene Name
ALG3
UniProt Synonym Gene Names
NOT; NOT56L
UniProt Entry Name
ALG3_HUMAN
NCBI Protein Information
dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase

NCBI Summary for ALG3

This gene encodes a member of the ALG3 family. The encoded protein catalyses the addition of the first dol-P-Man derived mannose in an alpha 1,3 linkage to Man5GlcNAc2-PP-Dol. Defects in this gene have been associated with congenital disorder of glycosylation type Id (CDG-Id) characterized by abnormal N-glycosylation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]
Show more

UniProt Comments for ALG3

ALG3: Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man5GlcNAc2-PP-Dol. Defects in ALG3 are the cause of congenital disorder of glycosylation type 1D (CDG1D); also known as carbohydrate-deficient glycoprotein syndrome type IV (CDGS4). CDGs are metabolic deficiencies in glycoprotein biosynthesis that usually cause severe mental and psychomotor retardation. They are characterized by under-glycosylated serum glycoproteins. Belongs to the glycosyltransferase 58 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Endoplasmic reticulum; Transferase; Membrane protein, integral; Glycan Metabolism - N-glycan biosynthesis; Membrane protein, multi-pass; EC 2.4.1.258

Chromosomal Location of Human Ortholog: 3q27.1

Cellular Component: endoplasmic reticulum membrane

Molecular Function: alpha-1,3-mannosyltransferase activity

Biological Process: dolichol-linked oligosaccharide biosynthetic process

Disease: Congenital Disorder Of Glycosylation, Type Id
Show more

Research Articles on ALG3

1. ALG3-CDG is due to an autosomal recessive defect in the ER mannosyl-transferase VI, which is involved in protein N-glycosylation. The enzyme is encoded by the ALG3 gene

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with ALG3 cdna clone

 Products by Pathway  Pathway Diagram
 Asparagine N-linked Glycosylation Pathway antibodies  Asparagine N-linked Glycosylation Pathway Diagram
 Biosynthesis Of The N-glycan Precursor (dolichol Lipid-linked Oligosaccharide, LLO) And Transfer To A Nascent Protein Pathway antibodies  Biosynthesis Of The N-glycan Precursor (dolichol Lipid-linked Oligosaccharide, LLO) And Transfer To A Nascent Protein Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 N-Glycan Biosynthesis Pathway antibodies  N-Glycan Biosynthesis Pathway Diagram
 N-Glycan Biosynthesis Pathway antibodies  N-Glycan Biosynthesis Pathway Diagram
 N-glycan Precursor Biosynthesis Pathway antibodies  N-glycan Precursor Biosynthesis Pathway Diagram
 N-glycan Precursor Biosynthesis Pathway antibodies  N-glycan Precursor Biosynthesis Pathway Diagram
 Post-translational Protein Modification Pathway antibodies  Post-translational Protein Modification Pathway Diagram
 Dolichyl-diphosphooligosaccharide Biosynthesis Pathway antibodies  Dolichyl-diphosphooligosaccharide Biosynthesis Pathway Diagram

Diseases associated with ALG3 cdna clone

 Disease Name  Pubmed Publications
 Microcephaly Antibodies  >5 publications with ALG3 and Microcephaly
 Nervous System Diseases Antibodies  >4 publications with ALG3 and Nervous System Diseases
 Neoplasms Antibodies  >2 publications with ALG3 and Neoplasms
 Brain Diseases Antibodies  >2 publications with ALG3 and Brain Diseases
 Uterine Cervical Neoplasms Antibodies  >1 publications with ALG3 and Uterine Cervical Neoplasms
 Hyperplasia Antibodies  >1 publications with ALG3 and Hyperplasia
 Congenital disorder of glycosylation type 1D Antibodies  >1 publications with ALG3 and Congenital disorder of glycosylation type 1D

Organs/Tissues associated with ALG3 cdna clone

 Organ/Tissue Name  Pubmed Publications
 Pancreas Antibodies  >2 publications with ALG3 and Pancreas
 Blood Antibodies  >1 publications with ALG3 and Blood
 Placenta Antibodies  >1 publications with ALG3 and Placenta
 Brain Antibodies  >1 publications with ALG3 and Brain
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000