Human ARHGEF3 cDNA Clone Expression Plasmid – Cat# MBS1269373

ARHGEF3 cDNA Clone – Nucleotide Exchange Factor (GEF) 3 (Human)

Name: ARHGEF3 cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1269373
Price: 615 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1269373

MBS1269373 is a cDNA clone targeting ARHGEF3. More details

$615 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

ARHGEF3, cDNA Clone

Full Product Name

ARHGEF3 cDNA Clone

Product Gene Name

ARHGEF3 cdna clone

Sequence

ATGGTGGCCA AGGATTACCC CTTCTACCTC ACGGTCAAGA GAGCGAACTG CAGCCTGGAG CTACCCCCGG CCAGCGGTCC GGCCAAGGAC GCTGAGGAGC CTAGTAATAA ACGGGTCAAA CCCCTTTCCC GAGTCACGTC GCTAGCAAAC CTCATCCCGC CCGTGAAGGC CACGCCATTA AAGCGCTTCA GTCAAACCCT GCAGCGCTCC ATTAGCTTCC GCAGTGAGAG CCGCCCTGAC ATCCTCGCCC CCCGACCCTG GTCCAGAAAT GCCGCCCCCT CGAGCACGAA ACGGAGAGAT AGCAAGCTGT GGAGTGAGAC CTTCGATGTG TGCGTCAATC AGATGCTTAC ATCCAAGGAA ATCAAACGTC AGGAGGCGAT CTTTGAGCTT TCCCAAGGAG AAGAAGACTT GATAGAAGAC TTGAAATTAG CAAAAAAGGC CTATCATGAC CCCATGCTGA AACTCTCCAT AATGACAGAA CAAGAGTTGA ATCAAATTTT TGGAACACTG GACTCTCTAA TTCCTCTACA TGAAGAGCTC CTTAGTCAGC TTCGAGATGT TAGGAAGCCT GATGGCTCGA CTGAACATGT TGGTCCCATC CTCGTGGGCT GGCTCCCTTG CCTCAGCTCC TATGATAGCT ACTGCAGCAA TCAAGTAGCC GCCAAAGCTC TGCTGGACCA CAAAAAGCAA GATCACCGAG TCCAGGATTT CCTACAGCGA TGTTTAGAAT CCCCCTTTAG CCGCAAACTA GATCTCTGGA ATTTCCTCGA TATTCCAAGA AGCCGCCTGG TAAAATACCC TCTGCTTCTC CGAGAAATCT TGAGGCACAC ACCAAATGAT AATCCAGATC AGCAGCACTT GGAAGAAGCT ATAAATATCA TTCAGGGAAT TGTGGCAGAA ATCAACACCA AGACTGGTGA ATCTGAATGC CGCTATTATA AAGAGCGGCT TCTTTACTTG GAAGAAGGCC AGAAAGACTC CCTGATCGAC AGCTCTCGAG TCTTGTGTTG TCATGGTGAA CTGAAGAACA ATCGGGGCGT GAAACTGCAT GTTTTCCTGT TCCAAGAAGT GCTTGTGATC ACTCGAGCCG TCACCCACAA TGAGCAGCTT TGCTACCAGC TGTACCGTCA GCCAATCCCC GTGAAAGACC TCCTGCTGGA AGACCTCCAG GATGGAGAAG TGAGGCTGGG TGGCTCCCTG CGAGGGGCAT TCAGCAACAA TGAGAGAATT AAAAACTTCT TCAGAGTCAG TTTCAAAAAT GGATCCCAAA GTCAGACCCA CTCGCTACAA GCCAATGACA CTTTCAACAA ACAGCAGTGG CTTAACTGTA TTCGTCAAGC CAAAGAAACA GTTTTGTGTG CTGCCGGGCA AGCTGGGGTG CTTGACTCCG AGGGATCGTT CCTAAATCCC ACCACCGGGA GCAGAGAGCT ACAGGGAGAA ACAAAACTTG AGCAGATGGA CCAATCGGAC AGTGAGTCAG ACTGTAGTAT GGACACGAGT GAGGTCAGCC TCGACTGTGA GCGCATGGAA CAGACAGACT CTTCCTGTGG AAACAGCAGG CACGGTGAAA GTAACGTCTG A

Molecular Weight

36,981 Da

OMIM

612115

Vector

Please Inquire

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of ARHGEF3 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ARHGEF3. It may not necessarily be applicable to this product.

NCBI GI #

32450711

NCBI GeneID

50650

NCBI Accession #

BC054345

UniProt Secondary Accession #

Q4FZB6; Q4QQI5; Q4QQQ0; Q59F00; Q6NUN3; Q7Z4U2; Q7Z5T2; Q9H7T4; A8K5U7

UniProt Related Accession #

Q9NR81

NCBI Official Full Name

Homo sapiens Rho guanine nucleotide exchange factor (GEF) 3, mRNA

NCBI Official Synonym Full Names

Rho guanine nucleotide exchange factor 3

NCBI Official Symbol

ARHGEF3

NCBI Official Synonym Symbols

GEF3; STA3; XPLN

UniProt Protein Name

Rho guanine nucleotide exchange factor 3

UniProt Synonym Protein Names

Exchange factor found in platelets and leukemic and neuronal tissues; XPLN

Protein Family

Rho guanine nucleotide exchange factor

UniProt Gene Name

ARHGEF3

UniProt Synonym Gene Names

XPLN

UniProt Entry Name

ARHG3_HUMAN

NCBI Protein Information

rho guanine nucleotide exchange factor 3

NCBI Summary for ARHGEF3

Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

UniProt Comments for ARHGEF3

ARHGEF3: Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: GAPs; Motility/polarity/chemotaxis; GAPs, Rac/Rho

Chromosomal Location of Human Ortholog: 3p14.3

Cellular Component: cytosol; intracellular

Molecular Function: guanyl-nucleotide exchange factor activity; protein binding; Rho guanyl-nucleotide exchange factor activity

Biological Process: positive regulation of apoptosis; regulation of small GTPase mediated signal transduction; Rho protein signal transduction

Research Articles on ARHGEF3

1. ARHGEF3 has a crucial role in myeloid differentiation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with ARHGEF3 cdna clone

Products by Pathway	Pathway Diagram
Cell Death Signalling Via NRAGE, NRIF And NADE Pathway antibodies	Cell Death Signalling Via NRAGE, NRIF And NADE Pathway Diagram
G Alpha (12/13) Signalling Events Pathway antibodies	G Alpha (12/13) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
NRAGE Signals Death Through JNK Pathway antibodies	NRAGE Signals Death Through JNK Pathway Diagram
Regulation Of RhoA Activity Pathway antibodies	Regulation Of RhoA Activity Pathway Diagram
Rho GTPase Cycle Pathway antibodies	Rho GTPase Cycle Pathway Diagram
Signal Transduction Pathway antibodies	Signal Transduction Pathway Diagram
Signaling By GPCR Pathway antibodies	Signaling By GPCR Pathway Diagram
Signaling By Rho GTPases Pathway antibodies	Signaling By Rho GTPases Pathway Diagram
Signalling By NGF Pathway antibodies	Signalling By NGF Pathway Diagram

Diseases associated with ARHGEF3 cdna clone

Disease Name	Pubmed Publications
Anemia Antibodies	>2 publications with ARHGEF3 and Anemia
Hematologic Diseases Antibodies	>1 publications with ARHGEF3 and Hematologic Diseases
Autoimmune Diseases Antibodies	>1 publications with ARHGEF3 and Autoimmune Diseases
Necrosis Antibodies	>1 publications with ARHGEF3 and Necrosis

Organs/Tissues associated with ARHGEF3 cdna clone

Organ/Tissue Name	Pubmed Publications
Bone Antibodies	>4 publications with ARHGEF3 and Bone
Blood Antibodies	>3 publications with ARHGEF3 and Blood
Brain Antibodies	>1 publications with ARHGEF3 and Brain