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ARPC2 cDNA Clone – Actin-Related Protein 2/3 Complex Subunit 2

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS200918

ARPC2 is one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. Two alternatively spliced variants have been… More details

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Product Overview

Online Datasheet in PDF
Product Name
ARPC2, cDNA Clone
Full Product Name
ARPC2
Product Gene Name
ARPC2 cdna clone
Product Synonym Names
ARC34; p34-Arc; PNAS-139; PRO2446
Sequence
Nucleotide Sequence: ATGATCCTGC TGGAGGTGAA CAACCGCATC ATCGAGGAGA CGCTCGCGCT CAAGTTCGAG AACGCGGCCG CCGGAAACAA ACCGGAAGCA GTAGAAGTAA CATTTGCAGA TTTCGATGGG GTCCTCTATC ATATTTCAAA TCCTAATGGA GACAAAACAA AAGTGATGGT CAGTATTTCT TTGAAATTCT ACAAGGAACT TCAGGCACAT GGTGCTGATG AGTTATTAAA GAGGGTGTAC GGGAGTTTCT TGGTAAATCC AGAATCAGGA TACAATGTCT CTTTGCTATA TGACCTTGAA AATCTTCCGG CATCCAAGGA TTCCATTGTG CATCAAGCTG GCATGTTGAA GCGAAATTGT TTTGCCTCTG TCTTTGAAAA ATACTTCCAA TTCCAAGAAG AGGGCAAGGA AGGAGAGAAC AGGGCAGTTA TCCATTATAG GGATGATGAG ACCATGTATG TTGAGTCTAA AAAGGACAGA GTCACAGTAG TCTTCAGCAC AGTGTTTAAG GATGACGACG ATGTGGTCAT TGGAAAGGTG TTCATGCAGG AGTTCAAAGA AGGACGCAGA GCCAGCCACA CAGCCCCACA GGTCCTCTTT AGCCACAGGG AACCTCCTCT GGAGCTGAAA GACACAGACG CCGCTGTGGG TGACAACATT GGCTACATTA CCTTTGTGCT GTTCCCTCGT CACACCAATG CCAGTGCTCG AGACAACACC ATCAACCTGA TCCACACGTT CCGGGACTAC CTGCACTACC ACATCAAGTG CTCTAAGGCC TATATTCACA CACGTATGCG GGCGAAAACG TCTGACTTCC TCAAGGTGCT GAACCGCGCA CGCCCAGATG CCGAGAAAAA AGAAATGAAA ACAATCACGG GGAAGACGTT TTCATCCCGC TAA

Translati on Sequence: MILLEVNNRI IEETLALKFE NAAAGNKPEA VEVTFADFDG VLYHISNPNG DKTKVMVSIS LKFYKELQAH GADELLKRVY GSFLVNPESG YNVSLLYDLE NLPASKDSIV HQAGMLKRNC FASVFEKYFQ FQEEGKEGEN RAVIHYRDDE TMYVESKKDR VTVVFSTVFK DDDDVVIGKV FMQEFKEGRR ASHTAPQVLF SHREPPLELK DTDAAVGDNI GYITFVLFPR HTNASARDNT INLIHTFRDY LHYHIKCSKA YIHTRMRAKT SDFLKVLNRA RPDAEKKEMK TITGKTFSSR
Form/Format
Lyophilized
Preparation and Storage
Store the plasmid at -20 degree C.
OMIM
604224
3D Structure
ModBase 3D Structure for O15144
Species
Human
Chromosome Location
2q36.1
OMIM Reference Number
604224
cDNA Size
903bp
Vector Description
This shuttle vector contains the complete ORF. It is inseted BamH I to Hind III. The gene insert contains multiple cloning sites which can be used to easily cut and transfer the gene and recombination site into your expression vector.
Vector
(puc19-derived cloning vector)
Preparation Before Usage
1. Centrifuge at 7000rpm for 1 minute. 2. Carefully open the vial and add 100ul of sterile water to dissolve the DNA. Each tube contains approximately 10ug of lyophilized plasmid.

Product Categories/Family for ARPC2 cdna clone

Signal Transduction

Other Notes

Small volumes of ARPC2 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ARPC2 purchase

MBS200918 is a cDNA clone targeting ARPC2.

Additional Details

NCBI/Uniprot data below describe general gene information for ARPC2. It may not necessarily be applicable to this product.

NCBI GI #
5031599
NCBI GeneID
10109
NCBI Accession #
NP_005722.1
UniProt Primary Accession #
O15144
UniProt Related Accession #
O15144
GenBank Nucleotide #
NM_005731.3
NCBI Official Full Name
actin-related protein 2/3 complex subunit 2
NCBI Official Synonym Full Names
actin related protein 2/3 complex subunit 2
NCBI Official Symbol
ARPC2
NCBI Official Synonym Symbols
ARC34; PRO2446; p34-Arc; PNAS-139
UniProt Protein Name
Actin-related protein 2/3 complex subunit 2
UniProt Synonym Protein Names
Arp2/3 complex 34 kDa subunit; p34-ARC
UniProt Gene Name
ARPC2
UniProt Synonym Gene Names
ARC34; p34-ARC
UniProt Entry Name
ARPC2_HUMAN
NCBI Protein Information
actin-related protein 2/3 complex subunit 2

NCBI Summary for ARPC2

This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p34 subunit, has yet to be determined. Two alternatively spliced variants have been characterized to date. Additional alternatively spliced variants have been described but their full length nature has not been determined. [provided by RefSeq, Jul 2008]
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UniProt Comments for ARPC2

ARPC2: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament. Belongs to the ARPC2 family.

Protein type: Cytoskeletal; Motility/polarity/chemotaxis; Actin-binding

Chromosomal Location of Human Ortholog: 2q36.1

Cellular Component: Golgi apparatus; Arp2/3 protein complex; neuron projection; focal adhesion; cytoplasm; leading edge; plasma membrane; synapse; cytosol; endosome; actin cytoskeleton

Molecular Function: actin filament binding; protein binding; structural constituent of cytoskeleton; kinesin binding

Biological Process: axon guidance; ephrin receptor signaling pathway; innate immune response; cell motility
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Research Articles on ARPC2

1. Study shows that the T-cell-specific deletion of Arpc2 results in compromised peripheral T-cell homeostasis suggesting that ARPC2 is essential for T-cell homeostasis probably by maintaining surface TCR levels via regulating TCR(+) endosome trafficking.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with ARPC2 cdna clone

 Reference Product  PubMed Publications
 ARPC3 cdna clone  >8 publications with ARPC2 and ARPC3
 ARPC5 cdna clone  >7 publications with ARPC2 and ARPC5
 NCKAP1 cdna clone  >1 publications with ARPC2 and NCKAP1
 Arc40 cdna clone  >1 publications with ARPC2 and Arc40
 ACTR2 cdna clone  >1 publications with ARPC2 and ACTR2
 ARPC1B cdna clone  >1 publications with ARPC2 and ARPC1B
 ACTR3 cdna clone  >1 publications with ARPC2 and ACTR3

Pathways associated with ARPC2 cdna clone

 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 CDC42 Signaling Events Pathway antibodies  CDC42 Signaling Events Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 EPH-Ephrin Signaling Pathway antibodies  EPH-Ephrin Signaling Pathway Diagram
 EPHB-mediated Forward Signaling Pathway antibodies  EPHB-mediated Forward Signaling Pathway Diagram
 ErbB1 Downstream Signaling Pathway antibodies  ErbB1 Downstream Signaling Pathway Diagram
 Fc Gamma R-mediated Phagocytosis Pathway antibodies  Fc Gamma R-mediated Phagocytosis Pathway Diagram

Diseases associated with ARPC2 cdna clone

 Disease Name  Pubmed Publications
 Colitis, Ulcerative Antibodies  >2 publications with ARPC2 and Colitis, Ulcerative
 Breast Neoplasms Antibodies  >1 publications with ARPC2 and Breast Neoplasms
 Hypertension Antibodies  >1 publications with ARPC2 and Hypertension
 Hypertrophy Antibodies  >1 publications with ARPC2 and Hypertrophy

Organs/Tissues associated with ARPC2 cdna clone

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >3 publications with ARPC2 and Muscle
 Thymus Antibodies  >2 publications with ARPC2 and Thymus
 Blood Antibodies  >2 publications with ARPC2 and Blood
 Connective Tissue Antibodies  >1 publications with ARPC2 and Connective Tissue
 Adipose Tissue Antibodies  >1 publications with ARPC2 and Adipose Tissue
 Lymph Node Antibodies  >1 publications with ARPC2 and Lymph Node
 Ovary Antibodies  >1 publications with ARPC2 and Ovary
 Liver Antibodies  >1 publications with ARPC2 and Liver
 Pancreas Antibodies  >1 publications with ARPC2 and Pancreas
 Kidney Antibodies  >1 publications with ARPC2 and Kidney
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