Human ATP2C1 cDNA Clone Expression Plasmid – Cat# MBS1270507

ATP2C1 cDNA Clone – Atpase, Ca++ Transporting, Type 2c, Member 1 (Human)

Name: ATP2C1 cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1270507
Price: 630 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1270507

MBS1270507 is a cDNA clone targeting ATP2C1. More details

$630 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

ATP2C1, cDNA Clone

Full Product Name

ATP2C1 cDNA Clone

Product Gene Name

ATP2C1 cdna clone

Sequence

atgaaggttg cacgttttca aaaaatacct aatggtgaaa atgagacaat gattcctgta ttgacatcaa aaaaagcaag tgaattacca gtcagtgaag ttgcaagcat tctccaagct gatcttcaga atggtctaaa caaatgtgaa gttagtcata ggcgagcctt tcatggctgg aatgagtttg atattagtga agatgagcca ctgtggaaga agtatatttc tcagtttaaa aatcccctta ttatgctgct tctggcttct gcagtcatca gtgttttaat gcatcagttt gatgatgccg tcagtatcac tgtggcaata cttatcgttg ttacagttgc ctttgttcag gaatatcgtt cagaaaaatc tcttgaagaa ttgagtaaac ttgtgccacc agaatgccat tgtgtgcgtg aaggaaaatt ggagcataca cttgcccgag acttggttcc aggtgataca gtttgccttt ctgttgggga tagagttcct gctgacttac gcttgtttga ggctgtggat ctttccattg atgagtccag cttgacaggt gagacaacgc cttgttctaa ggtgacagct cctcagccag ctgcaactaa tggagatctt gcatcgagaa gtaacattgc ctttatggga acactggtca gatgtggcaa agcaaagggt gttgtcattg gaacaggaga aaattctgaa tttggggagg tttttaaaat gatgcaagca gaagaggcac caaaaacccc tctgcagaag agcatggacc tcttaggaaa acaactttcc ttttactcct ttggtataat aggaatcatc atgttggttg gctggttact gggaaaagat atcctggaaa tgtttactat tagtgtaagt ttggctgtag cagcaattcc tgaaggtctc cccattgtgg tcacagtgac gctagctctt ggtgttatga gaatggtgaa gaaaagggcc attgtgaaaa agctgcctat tgttgaaact ctgggctgct gtaatgtgat ttgttcagat aaaactggaa cactgacgaa gaatgaaatg actgttactc acatatttac ttcagatggt ctgcatgctg aggttactgg agttggctat aatcaatttg gggaagtgat tgttgatggt gatgttgttc atggattcta taacccagct gttagcagaa ttgttgaggc gggctgtgtg tgcaatgatg ctgtaattag aaacaatact ctaatgggga agccaacaga aggggcctta attgctcttg caatgaagat gggtcttgat ggacttcaac aagactacat cagaaaagct gaataccctt ttagctctga gcaaaagtgg atggctgtta agtgtgtaca ccgaacacag caggacagac cagagatttg ttttatgaaa ggtgcttacg aacaagtaat taagtactgt actacatacc agagcaaagg gcagaccttg acacttactc agcagcagag agatgtgtac caacaagaga aggcacgcat gggctcagcg ggactcagag ttcttgcttt ggcttctggt cctgaactgg gacagctgac atttcttggc ttggtgggaa tcattgatcc acctagaact ggtgtgaaag aagctgttac aacactcatt gcctcaggag tatcaataaa aatgattact ggagattcac aggagactgc agttgcaatc gccagtcgtc tgggattgta ttccaaaact tcccagtcag tctcaggaga agaaatagat gcaatggatg ttcagcagct ttcacaaata gtaccaaagg ttgcagtatt ttacagagct agcccaaggc acaagatgaa aattattaag tcgctacaga agaacggttc agttgtagcc atgacaggag atggagtaaa tgatgcagtt gctctgaagg ctgcagacat tggagttgcg atgggccaga ctggtacaga tgtttgcaaa gaggcagcag acatgatcct agtggatgat gattttcaaa ccataatgtc tgcaatcgaa gagggtaaag ggatttataa taacattaaa aatttcgtta gattccagct gagcacgagt atagcagcat taactttaat ctcattggct acattaatga actttcctaa tcctctcaat gccatgcaga ttttgtggat caatattatt atggatggac ccccagctca gagccttgga gtagaaccag tggataaaga tgtcattcgt aaacctcctc gcaactggaa agacagcatt ttgactaaaa acttgatact taaaatactt gtttcatcaa taatcattgt ttgtgggact ttgtttgtct tctggcgtga gctacgagac aatgtgatta cacctcgaga cacaacaatg accttcacat gctttgtgtt ttttgacatg ttcaatgcac taagttccag atcccagacc aagtctgtgt ttgagattgg actctgcagt aatagaatgt tttgctatgc agttcttgga tccatcatgg gacaattact agttatttac tttcctccgc ttcagaaggt ttttcagact gagagcctaa gcatactggg tctggctctg ggagaggagt ggacagcagc tggttga

Molecular Weight

104,032 Da

OMIM

169600

Vector

pENTR223.1 or pUC

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of ATP2C1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ATP2C1. It may not necessarily be applicable to this product.

NCBI GI #

20380102

NCBI GeneID

27032

NCBI Accession #

BC028139

UniProt Secondary Accession #

O76005; Q86V72; Q86V73; Q8N6V1; Q8NCJ7; B2RAT7; B4DSW3; B7Z3X9; G3XAH8; G8JLN9

UniProt Related Accession #

P98194

NCBI Official Full Name

Homo sapiens ATPase, Ca++ transporting, type 2C, member 1, mRNA

NCBI Official Synonym Full Names

ATPase secretory pathway Ca2+ transporting 1

NCBI Official Symbol

ATP2C1

NCBI Official Synonym Symbols

HHD; BCPM; PMR1; SPCA1; hSPCA1; ATP2C1A

UniProt Protein Name

Calcium-transporting ATPase type 2C member 1

UniProt Synonym Protein Names

ATP-dependent Ca(2+) pump PMR1

Protein Family

Calcium-transporting ATPase

UniProt Gene Name

ATP2C1

UniProt Synonym Gene Names

KIAA1347; PMR1L; ATPase 2C1

UniProt Entry Name

AT2C1_HUMAN

NCBI Protein Information

calcium-transporting ATPase type 2C member 1

NCBI Summary for ATP2C1

The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium ions. Defects in this gene cause Hailey-Hailey disease, an autosomal dominant disorder. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

UniProt Comments for ATP2C1

ATP2C1: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium. Defects in ATP2C1 are the cause of Hailey-Hailey disease (HHD); also known as benign familial pemphigus. HHD is an autosomal dominant disorder characterized by persistent blisters and suprabasal cell separation (acantholysis) of the epidermis, due to impaired keratinocyte adhesion. Patients lacking all isoforms except isoform 2 have HHD. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Hydrolase; Membrane protein, integral; EC 3.6.3.8; Transporter, ion channel; Membrane protein, multi-pass; Transporter

Chromosomal Location of Human Ortholog: 3q22.1

Cellular Component: Golgi apparatus; Golgi membrane; integral to plasma membrane; membrane; trans-Golgi network

Molecular Function: calcium-transporting ATPase activity; signal transducer activity

Biological Process: actin cytoskeleton reorganization; calcium ion transport; calcium-dependent cell-cell adhesion; cellular calcium ion homeostasis; epidermis development; Golgi calcium ion homeostasis; Golgi calcium ion transport; positive regulation of I-kappaB kinase/NF-kappaB cascade

Disease: Benign Chronic Pemphigus

Research Articles on ATP2C1

1. Besides the level of functional ATP2C1 protein, levels of other ATPase proteins may influence expressivity of the disease and may also contribute to atypical presentations in three male members of the Hailey Hailey disease family.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with ATP2C1 cdna clone

Products by Pathway	Pathway Diagram
Ion Channel Transport Pathway antibodies	Ion Channel Transport Pathway Diagram
Ion Transport By P-type ATPases Pathway antibodies	Ion Transport By P-type ATPases Pathway Diagram
Transmembrane Transport Of Small Molecules Pathway antibodies	Transmembrane Transport Of Small Molecules Pathway Diagram
Calcium Transport I Pathway antibodies	Calcium Transport I Pathway Diagram

Diseases associated with ATP2C1 cdna clone

Disease Name	Pubmed Publications
Pemphigus, Benign Familial Antibodies	>74 publications with ATP2C1 and Pemphigus, Benign Familial
Death Antibodies	>5 publications with ATP2C1 and Death
Neoplasms Antibodies	>5 publications with ATP2C1 and Neoplasms
Nervous System Diseases Antibodies	>5 publications with ATP2C1 and Nervous System Diseases
Carcinoma Antibodies	>4 publications with ATP2C1 and Carcinoma
Drug Toxicity Antibodies	>3 publications with ATP2C1 and Drug Toxicity
Breast Neoplasms Antibodies	>2 publications with ATP2C1 and Breast Neoplasms
Carcinoma, Squamous Cell Antibodies	>2 publications with ATP2C1 and Carcinoma, Squamous Cell
Congenital Abnormalities Antibodies	>2 publications with ATP2C1 and Congenital Abnormalities
Cell Transformation, Neoplastic Antibodies	>1 publications with ATP2C1 and Cell Transformation, Neoplastic

Organs/Tissues associated with ATP2C1 cdna clone

Organ/Tissue Name	Pubmed Publications
Skin Antibodies	>52 publications with ATP2C1 and Skin
Blood Antibodies	>8 publications with ATP2C1 and Blood
Brain Antibodies	>8 publications with ATP2C1 and Brain
Muscle Antibodies	>6 publications with ATP2C1 and Muscle
Mammary Gland Antibodies	>5 publications with ATP2C1 and Mammary Gland
Liver Antibodies	>4 publications with ATP2C1 and Liver
Lung Antibodies	>3 publications with ATP2C1 and Lung
Vascular Antibodies	>3 publications with ATP2C1 and Vascular
Pancreas Antibodies	>3 publications with ATP2C1 and Pancreas
Heart Antibodies	>2 publications with ATP2C1 and Heart