Human AXL cDNA Clone Expression Plasmid – Cat# MBS1269583

AXL cDNA Clone – AXL Receptor Tyrosine Kinase (Human)

Name: AXL cDNA Clone; AXL Receptor Tyrosine Kinase; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1269583
Price: 990 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1269583

MBS1269583 is a cDNA clone targeting AXL. More details

$990 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

AXL, cDNA Clone

Full Product Name

AXL cDNA Clone

Product Gene Name

AXL cdna clone

Sequence

atggcgtggc ggtgccccag gatgggcagg gtcccgctgg cctggtgctt ggcgctgtgc ggctgggcgt gcatggcccc caggggcacg caggctgaag aaagtccctt cgtgggcaac ccagggaata tcacaggtgc ccggggactc acgggcaccc ttcggtgtca gctccaggtt cagggagagc cccccgaggt acattggctt cgggatggac agatcctgga gctcgcggac agcacccaga cccaggtgcc cctgggtgag gatgaacagg atgactggat agtggtcagc cagctcagaa tcacctccct gcagctttcc gacacgggac agtaccagtg tttggtgttt ctgggacatc agaccttcgt gtcccagcct ggctatgttg ggctggaggg cttgccttac ttcctggagg agcccgaaga caggactgtg gccgccaaca cccccttcaa cctgagctgc caagctcagg gacccccaga gcccgtggac ctactctggc tccaggatgc tgtccccctg gccacggctc caggtcacgg cccccagcgc agcctgcatg ttccagggct gaacaagaca tcctctttct cctgcgaagc ccataacgcc aagggggtca ccacatcccg cacagccacc atcacagtgc tcccccagca gccccgtaac ctccacctgg tctcccgcca acccacggag ctggaggtgg cttggactcc aggcctgagc ggcatctacc ccctgaccca ctgcaccctg caggctgtgc tgtcagacga tgggatgggc atccaggcgg gagaaccaga ccccccagag gagcccctca cctcgcaagc atccgtgccc ccccatcagc ttcggctagg cagcctccat cctcacaccc cttatcacat ccgcgtggca tgcaccagca gccagggccc ctcatcctgg acccactggc ttcctgtgga gacgccggag ggagtgcccc tgggcccccc tgagaacatt agtgctacgc ggaatgggag ccaggccttc gtgcattggc aagagccccg ggcgcccctg cagggtaccc tgttagggta ccggctggcg tatcaaggcc aggacacccc agaggtgcta atggacatag ggctaaggca agaggtgacc ctggagctgc agggggacgg gtctgtgtcc aatctgacag tgtgtgtggc agcctacact gctgctgggg atggaccctg gagcctccca gtacccctgg aggcctggcg cccagggcaa gcacagccag tccaccagct ggtgaaggaa ccttcaactc ctgccttctc gtggccctgg tggtatgtac tgctaggagc agtcgtggcc gctgcctgtg tcctcatctt ggctctcttc cttgtccacc ggcgaaagaa ggagacccgt tatggagaag tgtttgaacc aacagtggaa agaggtgaac tggtagtcag gtaccgcgtg cgcaagtcct acagtcgtcg gaccactgaa gctaccttga acagcttggg catcagtgaa gagctgaagg agaagctgcg ggatgtgatg gtggaccggc acaaggtggc cctggggaag actctgggag agggagagtt tggagctgtg atggaaggcc agctcaacca ggacgactcc atcctcaagg tggctgtgaa gacgatgaag attgccatct gcacgaggtc agagctggag gatttcctga gtgaagcggt ctgcatgaag gaatttgacc atcccaacgt catgaggctc atcggtgtct gtttccaggg ttctgaacga gagagcttcc cagcacctgt ggtcatctta cctttcatga aacatggaga cctacacagc ttcctcctct attcccggct cggggaccag ccagtgtacc tgcccactca gatgctagtg aagttcatgg cagacatcgc cagtggcatg gagtatctga gtaccaagag attcatacac cgggacctgg cggccaggaa ctgcatgctg aatgagaaca tgtccgtgtg tgtggcggac ttcgggctct ccaagaagat ctacaatggg gactactacc gccagggacg tatcgccaag atgccagtca agtggattgc cattgagagt ctagctgacc gtgtctacac cagcaagagc gatgtgtggt ccttcggggt gacaatgtgg gagattgcca caagaggcca aaccccatat ccgggcgtgg agaacagcga gatttatgac tatctgcgcc ggggaaatcg cctgaagcag cctgcggact gtctggatgg actgtatgcc ttgatgtcgc ggtgctggga gctaaatccc caggaccggc caagttttac agagctgcgg gaagatttgg agaacacact gaaggccttg cctcctgccc aggagcctga cgaaatcctc tatgtcaaca tggatgaggg tggaggttat cctgaacccc ctggagctgc aggaggagct gaccccccaa cccagccaga ccctaaggat tcctgtagct gcctcactgc ggctgaggtc catcctgctg gacgctatgt cctctgccct tccacaaccc ctagccccgc tcagcctgct gataggggct ccccagcagc cccagggcag gaggatggtg cctga

Molecular Weight

97,377 Da

OMIM

109135

Vector

Please Inquire

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of AXL cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for AXL. It may not necessarily be applicable to this product.

NCBI GI #

21619003

NCBI GeneID

558

NCBI Accession #

BC032229

UniProt Secondary Accession #

Q8N5L2; Q9UD27

UniProt Related Accession #

P30530

NCBI Official Full Name

Homo sapiens AXL receptor tyrosine kinase, mRNA

NCBI Official Synonym Full Names

AXL receptor tyrosine kinase

NCBI Official Symbol

AXL

NCBI Official Synonym Symbols

ARK; UFO; JTK11; Tyro7

UniProt Protein Name

Tyrosine-protein kinase receptor UFO

UniProt Synonym Protein Names

AXL oncogene

Protein Family

Tyrosine-protein kinase receptor

UniProt Gene Name

AXL

UniProt Synonym Gene Names

UFO

UniProt Entry Name

UFO_HUMAN

NCBI Protein Information

tyrosine-protein kinase receptor UFO

NCBI Summary for AXL

The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

UniProt Comments for AXL

AXL: a receptor tyrosine kinase that may function as a signal transducer between specific cell types of mesodermal origin. Interacts with SKP1. Overexpression in tissue culture causes oncogenic transformation. Overexpressed in several cancers including thyroid, ovarian, gastric, ER+ breast cancer and acute myeloid leukemia, where it is associated with poor prognosis. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Kinase, protein; Membrane protein, integral; Oncoprotein; EC 2.7.10.1; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group; Axl family

Chromosomal Location of Human Ortholog: 19q13.1

Cellular Component: cell surface; extracellular space; integral to plasma membrane; plasma membrane

Molecular Function: phosphatidylserine binding; protein binding; protein-tyrosine kinase activity

Biological Process: cell maturation; entry of virus into host cell; negative regulation of interferon-gamma production; phagocytosis; positive regulation of cytokine and chemokine mediated signaling pathway; positive regulation of natural killer cell differentiation; positive regulation of pinocytosis; signal transduction; vascular endothelial growth factor receptor signaling pathway

Research Articles on AXL

1. Incubation with sunitinib of renal cell carcinoma cells causes significant upregulation of multiple phosphopeptides including Axl.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with AXL cdna clone

Disease Name	Pubmed Publications
Neoplasms Antibodies	>155 publications with AXL and Neoplasms
Carcinoma Antibodies	>63 publications with AXL and Carcinoma
Inflammation Antibodies	>47 publications with AXL and Inflammation
Neoplasm Metastasis Antibodies	>31 publications with AXL and Neoplasm Metastasis
Nervous System Diseases Antibodies	>29 publications with AXL and Nervous System Diseases
Disease Models, Animal Antibodies	>29 publications with AXL and Disease Models, Animal
Adenocarcinoma Antibodies	>28 publications with AXL and Adenocarcinoma
Lung Neoplasms Antibodies	>26 publications with AXL and Lung Neoplasms
Breast Neoplasms Antibodies	>25 publications with AXL and Breast Neoplasms
Necrosis Antibodies	>25 publications with AXL and Necrosis

Organs/Tissues associated with AXL cdna clone

Organ/Tissue Name	Pubmed Publications
Vascular Antibodies	>76 publications with AXL and Vascular
Brain Antibodies	>45 publications with AXL and Brain
Eye Antibodies	>44 publications with AXL and Eye
Lung Antibodies	>40 publications with AXL and Lung
Muscle Antibodies	>40 publications with AXL and Muscle
Kidney Antibodies	>38 publications with AXL and Kidney
Bone Antibodies	>35 publications with AXL and Bone
Bone Marrow Antibodies	>28 publications with AXL and Bone Marrow
Liver Antibodies	>25 publications with AXL and Liver
Embryonic Tissue Antibodies	>16 publications with AXL and Embryonic Tissue