Human BCHE cDNA Clone Expression Plasmid – Cat# MBS1271352

BCHE cDNA Clone – Butyrylcholinesterase (Human)

Name: BCHE cDNA Clone; Butyrylcholinesterase; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1271352
Price: 235 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1271352

MBS1271352 is a cDNA clone targeting BCHE. Homo sapiens butyrylcholinesterase, mRNA complete cds. More details

$235 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

BCHE, cDNA Clone

Full Product Name

BCHE cDNA Clone

Product Gene Name

BCHE cdna clone

Product Synonym Names

Sequence

atgcatagca aagtcacaat catatgcatc agatttctct tttggtttct tttgctctgc atgcttattg ggaagtcaca tactgaagat gacatcataa ttgcaacaaa gaatggaaaa gtcagaggga tgaacttgac agtttttggt ggcacggtaa cagcctttct tggaattccc tatgcacagc cacctcttgg tagacttcga ttcaaaaagc cacagtctct gaccaagtgg tctgatattt ggaatgccac aaaatatgca aattcttgct gtcagaacat agatcaaagt tttccaggct tccatggatc agagatgtgg aacccaaaca ctgacctcag tgaagactgt ttatatctaa atgtatggat tccagcacct aaaccaaaaa atgccactgt attgatatgg atttatggtg gtggttttca aactggaaca tcatctttac atgtttatga tggcaagttt ctggctcggg ttgaaagagt tattgtagtg tcaatgaact atagggtggg tgccctagga ttcttagctt tgccaggaaa tcctgaggct ccagggaaca tgggtttatt tgatcaacag ttggctcttc agtgggttca aaaaaatata gcagcctttg gtggaaatcc taaaagtgta actctctttg gagaaagtgc aggagcagct tcagttagcc tgcatttgct ttctcctgga agccattcat tgttcaccag agccattctg caaagtggat cctttaatgc tccttgggcg gtaacatctc tttatgaagc taggaacaga acgttgaact tagctaaatt gactggttgc tctagagaga atgagactga aataatcaag tgtcttagaa ataaagatcc ccaagaaatt cttctgaatg aagcatttgt tgtcccctat gggactcctt tgtcagtaaa ctttggtccg accgtggatg gtgattttct cactgacatg ccagacatat tacttgaact tggacaattt aaaaaaaccc agattttggt gggtgttaat aaagatgaag ggacagcttt tttagtctat ggtgctcctg gcttcagcaa agataacaat agtatcataa ctagaaaaga atttcaggaa ggtttaaaaa tattttttcc aggagtgagt gagtttggaa aggaatccat cctttttcat tacacagact gggtagatga tcagagacct gaaaactacc gtgaggcctt gggtgatgtt gttggggatt ataatttcat atgccctgcc ttggagttca ccaagaagtt ctcagaatgg ggaaataatg cctttttcta ctattttgaa caccgatcct ccaaacttcc gtggccagaa tggatgggag tgatgcatgg ctatgaaatt gaatttgtct ttggtttacc tctggaaaga agagataatt acacaaaagc cgaggaaatt ttgagtagat ccatagtgaa acggtgggca aattttgcaa aatatgggaa tccaaatgag actcagaaca atagcacaag ctggcctgtc ttcaaaagca ctgaacaaaa atatctaacc ttgaatacag agtcaacaag aataatgacg aaactacgtg ctcaacaatg tcgattctgg acatcatttt ttccaaaagt cttggaaatg acaggaaata ttgatgaagc agaatgggag tggaaagcag gattccatcg ctggaacaat tacatgatgg actggaaaaa tcaatttaac gattacacta gcaagaaaga aagttgtgtg ggtctctaa

Molecular Weight

68,418 Da

Chromosome Location

Chromosome: 3; NC_000003.11 (165490692..165555253, complement). Location: 3q26.1-q26.2

OMIM

177400

3D Structure

ModBase 3D Structure for P06276

Vector

pENTR223.1

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of BCHE cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for BCHE. It may not necessarily be applicable to this product.

NCBI GI #

17390311

NCBI GeneID

590

NCBI Accession #

BC018141

UniProt Primary Accession #

P06276

UniProt Secondary Accession #

A8K7P8

UniProt Related Accession #

P06276

NCBI Official Full Name

Homo sapiens butyrylcholinesterase, mRNA

NCBI Official Synonym Full Names

butyrylcholinesterase

NCBI Official Symbol

BCHE

NCBI Official Synonym Symbols

E1; CHE1

UniProt Protein Name

Cholinesterase

UniProt Synonym Protein Names

Acylcholine acylhydrolase; Butyrylcholine esterase; Choline esterase II; Pseudocholinesterase

Protein Family

Anaerobic magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase

UniProt Gene Name

BCHE

UniProt Synonym Gene Names

CHE1

UniProt Entry Name

CHLE_HUMAN

NCBI Protein Information

cholinesterase; cholinesterase 1; choline esterase II; pseudocholinesterase; butyrylcholine esterase; acylcholine acylhydrolase

NCBI Summary for BCHE

Mutant alleles at the BCHE locus are responsible for suxamethonium sensitivity. Homozygous persons sustain prolonged apnea after administration of the muscle relaxant suxamethonium in connection with surgical anesthesia. The activity of pseudocholinesterase in the serum is low and its substrate behavior is atypical. In the absence of the relaxant, the homozygote is at no known disadvantage. [provided by RefSeq, Jul 2008]

UniProt Comments for BCHE

BCHE: Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters. Defects in BCHE are the cause of butyrylcholinesterase deficiency (BChE deficiency). BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnoea varies significantly depending on the extent of the enzyme deficiency. BChE deficiency is a multifactorial disorder. The hereditary condition is transmitted as an autosomal recessive trait. Belongs to the type-B carboxylesterase/lipase family.

Protein type: Nuclear envelope; Hydrolase; EC 3.1.1.8; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 3q26.1-q26.2

Cellular Component: membrane; endoplasmic reticulum lumen; nuclear envelope lumen; extracellular region

Molecular Function: choline binding; identical protein binding; enzyme binding; cholinesterase activity; beta-amyloid binding; acetylcholinesterase activity; catalytic activity

Biological Process: response to alkaloid; response to drug; negative regulation of cell proliferation; cellular protein metabolic process; cocaine metabolic process; choline metabolic process; response to folic acid; response to glucocorticoid stimulus; neuroblast differentiation; learning; negative regulation of synaptic transmission

Research Articles on BCHE

1. characterized the catalytic activities of wild-type BChE and the A199S/F227A/S287G/A328 W/Y332G mutant against both (+)- and (-)-cocaine at the same time under the same experimental conditions

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with BCHE cdna clone

Products by Pathway	Pathway Diagram
Irinotecan Pathway antibodies	Irinotecan Pathway Diagram
Metabolism Of Proteins Pathway antibodies	Metabolism Of Proteins Pathway Diagram
Peptide Hormone Metabolism Pathway antibodies	Peptide Hormone Metabolism Pathway Diagram
Synthesis, Secretion, And Deacylation Of Ghrelin Pathway antibodies	Synthesis, Secretion, And Deacylation Of Ghrelin Pathway Diagram

Diseases associated with BCHE cdna clone

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>153 publications with BCHE and Nervous System Diseases
Central Nervous System Diseases Antibodies	>137 publications with BCHE and Central Nervous System Diseases
Drug Toxicity Antibodies	>132 publications with BCHE and Drug Toxicity
Poisoning Antibodies	>74 publications with BCHE and Poisoning
Organophosphate Poisoning Antibodies	>37 publications with BCHE and Organophosphate Poisoning
Death Antibodies	>27 publications with BCHE and Death
Apnea Antibodies	>24 publications with BCHE and Apnea
Obesity Antibodies	>18 publications with BCHE and Obesity
Cocaine-Related Disorders Antibodies	>9 publications with BCHE and Cocaine-Related Disorders
Seizures Antibodies	>9 publications with BCHE and Seizures

Organs/Tissues associated with BCHE cdna clone

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>201 publications with BCHE and Brain
Nerve Antibodies	>134 publications with BCHE and Nerve
Muscle Antibodies	>91 publications with BCHE and Muscle
Liver Antibodies	>59 publications with BCHE and Liver
Heart Antibodies	>30 publications with BCHE and Heart
Lung Antibodies	>26 publications with BCHE and Lung
Eye Antibodies	>19 publications with BCHE and Eye
Intestine Antibodies	>19 publications with BCHE and Intestine
Embryonic Tissue Antibodies	>18 publications with BCHE and Embryonic Tissue
Kidney Antibodies	>16 publications with BCHE and Kidney