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BHMT cDNA Clone – Betaine-Homocysteine Methyltransferase (Human)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1276549

MBS1276549 is a cDNA clone targeting BHMT. More details

$235 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
BHMT, cDNA Clone
Full Product Name
BHMT cDNA Clone
Product Gene Name
BHMT cdna clone
Sequence
atgccacccg ttgggggcaa aaaggccaag aagggcatcc tagaacgttt aaatgctgga gagattgtga ttggagatgg agggtttgtc tttgcactgg agaagagggg ctacgtaaag gcaggaccct ggactcctga agctgctgtg gagcacccag aagcagttcg ccagcttcat cgagagttcc tcagagctgg ctcaaacgtc atgcagacct tcaccttcta tgcgagtgaa gacaagctgg agaacagggg caactatgtc ttagagaaga tatctgggca ggaagtcaat gaagctgctt gcgacatcgc ccgacaagtg gctgatgaag gagatgcttt ggtagcagga ggagtgagtc agacaccttc ataccttagc tgcaagagtg aaactgaagt caaaaaagta tttctgcaac agttagaggt ctttatgaag aagaacgtgg acttcttgat tgcagagtat tttgaacacg ttgaagaagc tgtgtgggca gttgaaacct tgatagcatc cggtaaacct gtggcagcaa ccatgtgcat tggcccagaa ggagatttgc atggcgtgcc ccccggcgag tgtgcagtgc gcctggtgaa agcaggagca tccatcattg gtgtgaactg ccactttgac cccaccatta gtttaaaaac agtgaagctc atgaaggagg gcttggaggc tgcccgactg aaagctcacc tgatgagcca gcccttggct taccacactc ctgactgcaa caagcaggga ttcatcgatc tcccagaatt cccatttgga ctggaaccca gagttgccac cagatgggat attcaaaaat acgccagaga ggcctacaac ctgggggtca ggtacattgg cgggtgctgt ggatttgagc cctaccacat cagggcaatt gcagaggagc tggccccaga aaggggcttt ttgccaccag cttcagaaaa acatggcagc tggggaagtg gtttggacat gcacaccaaa ccctgggtta gagcaagggc caggaaggaa tactgggaga atcttcggat agcctcaggc cggccataca acccttcaat gtcaaagcca gatggctggg gagtgaccaa aggaacagcc gagctgatgc agcagaaaga agccacaact gagcagcagc tgaaagagct ctttgaaaaa caaaaattca aatcacagta g
Molecular Weight
44,998 Da
OMIM
602888
Vector
pENTR223.1
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of BHMT cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for BHMT. It may not necessarily be applicable to this product.

NCBI GI #
15214971
NCBI GeneID
635
NCBI Accession #
BC012616
UniProt Secondary Accession #
Q9UNI9
UniProt Related Accession #
Q93088
NCBI Official Full Name
Homo sapiens betaine-homocysteine methyltransferase, mRNA
NCBI Official Synonym Full Names
betaine--homocysteine S-methyltransferase
NCBI Official Symbol
BHMT
NCBI Official Synonym Symbols
BHMT1; HEL-S-61p
UniProt Protein Name
Betaine--homocysteine S-methyltransferase 1
Protein Family
Betaine--homocysteine S-methyltransferase
UniProt Gene Name
BHMT
UniProt Entry Name
BHMT1_HUMAN
NCBI Protein Information
betaine--homocysteine S-methyltransferase 1

NCBI Summary for BHMT

This gene encodes a cytosolic enzyme that catalyzes the conversion of betaine and homocysteine to dimethylglycine and methionine, respectively. Defects in this gene could lead to hyperhomocyst(e)inemia, but such a defect has not yet been observed. [provided by RefSeq, Jul 2008]

UniProt Comments for BHMT

BHMT: Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline.

Protein type: Amino Acid Metabolism - glycine, serine and threonine; Amino Acid Metabolism - cysteine and methionine; Methyltransferase; EC 2.1.1.5

Chromosomal Location of Human Ortholog: 5q14.1

Cellular Component: cytoplasm; cytosol

Molecular Function: betaine-homocysteine S-methyltransferase activity; homocysteine S-methyltransferase activity; zinc ion binding

Biological Process: betaine metabolic process; choline catabolic process; S-adenosylmethionine metabolic process; sulfur amino acid metabolic process
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Research Articles on BHMT

1. The faster evolutionary rate of BHMT2 overall suggests that selective constraints were reduced relative to BHMT.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with BHMT cdna clone

 Products by Pathway  Pathway Diagram
 Cysteine And Methionine Metabolism Pathway antibodies  Cysteine And Methionine Metabolism Pathway Diagram
 Cysteine And Methionine Metabolism Pathway antibodies  Cysteine And Methionine Metabolism Pathway Diagram
 Glycine, Serine And Threonine Metabolism Pathway antibodies  Glycine, Serine And Threonine Metabolism Pathway Diagram
 Glycine, Serine And Threonine Metabolism Pathway antibodies  Glycine, Serine And Threonine Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram
 One Carbon Metabolism Pathway antibodies  One Carbon Metabolism Pathway Diagram
 Sulfur Amino Acid Metabolism Pathway antibodies  Sulfur Amino Acid Metabolism Pathway Diagram
 Glycine Betaine Degradation Pathway antibodies  Glycine Betaine Degradation Pathway Diagram
 Methionine Salvage II (mammalia) Pathway antibodies  Methionine Salvage II (mammalia) Pathway Diagram

Diseases associated with BHMT cdna clone

 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >24 publications with BHMT and Liver Diseases
 Neoplasms Antibodies  >23 publications with BHMT and Neoplasms
 Cardiovascular Diseases Antibodies  >21 publications with BHMT and Cardiovascular Diseases
 Carcinoma Antibodies  >18 publications with BHMT and Carcinoma
 Nervous System Diseases Antibodies  >13 publications with BHMT and Nervous System Diseases
 Fatty Liver Antibodies  >12 publications with BHMT and Fatty Liver
 Disease Models, Animal Antibodies  >9 publications with BHMT and Disease Models, Animal
 Carcinoma, Hepatocellular Antibodies  >9 publications with BHMT and Carcinoma, Hepatocellular
 Kidney Diseases Antibodies  >7 publications with BHMT and Kidney Diseases
 Liver Neoplasms Antibodies  >7 publications with BHMT and Liver Neoplasms

Organs/Tissues associated with BHMT cdna clone

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >108 publications with BHMT and Liver
 Kidney Antibodies  >25 publications with BHMT and Kidney
 Brain Antibodies  >6 publications with BHMT and Brain
 Intestine Antibodies  >3 publications with BHMT and Intestine
 Eye Antibodies  >3 publications with BHMT and Eye
 Embryonic Tissue Antibodies  >1 publications with BHMT and Embryonic Tissue
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