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BPHL cDNA Clone – Biphenyl Hydrolase-Like (Serine Hydrolase) (Human)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1272526

MBS1272526 is a cDNA clone targeting BPHL. More details

$235 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
BPHL, cDNA Clone
Full Product Name
BPHL cDNA Clone
Product Gene Name
BPHL cdna clone
Sequence
ATGCCCAGGA ATCTGCTTTA TTCTCTTTTG TCCTCCCACC TGTCCCCCCA TTTCAGCACC TCGGTAACCT CTGCCAAAGT GGCTGTGAAT GGCGTTCAGC TGCATTACCA GCAGACTGGA GAGGGAGATC ACGCAGTCCT GCTACTTCCT GGGATGTTAG GAAGTGGAGA GACTGATTTT GGACCTCAGC TCAAGAACCT CAATAAGAAG CTCTTCACGG TGGTCGCCTG GGATCCTCGA GGCTATGGAC ATTCCAGGCC CCCAGATCGC GATTTCCCAG CAGACTTTTT TGAAAGGGAT GCAAAAGATG CTGTTGATTT GATGAAGGCG CTGAAGTTTA AGAAGGTTTC TCTGCTGGGG TGGAGTGATG GGGGCATAAC CGCACTCATT GCTGCTGCAA AATATCCATC TTACATCCAC AAGATGGTGA TCTGGGGCGC CAACGCCTAC GTCACTGACG AAGACAGCAT GATATATGAG GGCATCCGAG ATGTTTCCAA ATGGAGTGAG AGAACAAGAA AGCCTCTAGA AGCCCTCTAT GGGTATGACT ACTTTGCCAG AACCTGTGAA AAGTGGGTGG ATGGCATAAG ACAGTTTAAA CATCTCCCAG ATGGTAACAT CTGCCGGCAC CTGCTGCCCC GGGTCCAGTG CCCCGCCTTG ATTGTGCACG GTGAGAAGGA TCCTCTGGTC CCACGGTTTC ATGCCGACTT CATTCATAAG CACGTGAAAG GCTCACGGCT GCATTTGATG CCAGAAGGCA AACACAACCT GCATTTGCGT TTTGCAGATG AATTCAACAA GTTAGCAGAA GACTTCCTAC AATGA
Molecular Weight
31,107 Da
OMIM
603156
Vector
pENTR223.1 or pUC
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of BPHL cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for BPHL. It may not necessarily be applicable to this product.

NCBI GI #
76827873
NCBI GeneID
670
NCBI Accession #
BC106901
UniProt Secondary Accession #
Q00306; Q13855; Q3KP51
UniProt Related Accession #
Q86WA6
NCBI Official Full Name
Homo sapiens biphenyl hydrolase-like (serine hydrolase), mRNA
NCBI Official Synonym Full Names
biphenyl hydrolase like
NCBI Official Symbol
BPHL
NCBI Official Synonym Symbols
MCNAA; BPH-RP; VACVASE
UniProt Protein Name
Valacyclovir hydrolase
UniProt Synonym Protein Names
Biphenyl hydrolase-like protein; Biphenyl hydrolase-related protein; Bph-rp; Breast epithelial mucin-associated antigen; MCNAA
Protein Family
Valacyclovir hydrolase
UniProt Gene Name
BPHL
UniProt Synonym Gene Names
MCNAA; VACVase; Valacyclovirase; Bph-rp; MCNAA
UniProt Entry Name
BPHL_HUMAN
NCBI Protein Information
valacyclovir hydrolase

NCBI Summary for BPHL

This gene encodes a member of the serine protease family of hydrolytic enzymes which contain a serine in their active site. The encoded protein may play a role in activation of the antiviral prodrug valacyclovir. Alternatively spliced transcript variants have been described.[provided by RefSeq, Jan 2009]
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UniProt Comments for BPHL

BPHL: Serine hydrolase that catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir. Activates valacyclovir to acyclovir. May play a role in detoxification processes. It is a specific alpha-amino acid ester hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol. Belongs to the AB hydrolase superfamily. Lipase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.-.-; Hydrolase

Chromosomal Location of Human Ortholog: 6p25

Cellular Component: mitochondrial outer membrane; mitochondrion

Molecular Function: alpha-amino-acid esterase activity; hydrolase activity

Biological Process: amino acid metabolic process; response to toxin; xenobiotic metabolic process
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Research Articles on BPHL

1. The catalytic efficiency (kcat/Km) of rBPHL for homocysteine thiolactone hydrolysis was 7.7 x 10(4) M(-1)s(-1), orders of magnitude higher than that of PON1 or Blmh, indicating a more significant physiological role for BPHL in detoxifying HCTL

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with BPHL cdna clone

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >2 publications with BPHL and Neoplasms
 Kidney Neoplasms Antibodies  >2 publications with BPHL and Kidney Neoplasms
 Fibrosis Antibodies  >1 publications with BPHL and Fibrosis
 Breast Neoplasms Antibodies  >1 publications with BPHL and Breast Neoplasms
 Weight Loss Antibodies  >1 publications with BPHL and Weight Loss
 Kidney Diseases Antibodies  >1 publications with BPHL and Kidney Diseases
 Liver Neoplasms Antibodies  >1 publications with BPHL and Liver Neoplasms

Organs/Tissues associated with BPHL cdna clone

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >4 publications with BPHL and Kidney
 Intestine Antibodies  >2 publications with BPHL and Intestine
 Heart Antibodies  >1 publications with BPHL and Heart
 Liver Antibodies  >1 publications with BPHL and Liver
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