Human C5 cDNA Clone Expression Plasmid – Cat# MBS1269057

C5 cDNA Clone – Complement Component 5 (Human)

Name: C5 cDNA Clone; Complement Component 5; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1269057
Availability: InStock
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For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1269057

MBS1269057 is a cDNA clone targeting C5. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

C5, cDNA Clone

Full Product Name

C5 cDNA Clone

Product Gene Name

C5 cdna clone

Sequence

atgggccttt tgggaatact ttgtttttta atcttcctgg ggaaaacctg gggacaggag caaacatatg tcatttcagc accaaaaata ttccgtgttg gagcatctga aaatattgtg attcaagttt atggatacac tgaagcattt gatgcaacaa tctctattaa aagttatcct gataaaaaat ttagttactc ctcaggccat gttcatttat cctcagagaa taaattccaa aactctgcaa tcttaacaat acaaccaaaa caattgcctg gaggacaaaa cccagtttct tatgtgtatt tggaagttgt atcaaagcat ttttcaaaat caaaaagaat gccaataacc tatgacaatg gatttctctt cattcataca gacaaacctg tttatactcc agaccagtca gtaaaagtta gagtttattc gttgaatgac gacttgaagc cagccaaaag agaaactgtc ttaactttca tagatcctga aggatcagaa gttgacatgg tagaagaaat tgatcatatt ggaattatct cttttcctga cttcaagatt ccgtctaatc ctagatatgg tatgtggacg atcaaggcta aatataaaga ggacttttca acaactggaa ccgcatattt tgaagttaaa gaatatgtct tgccacattt ttctgtctca atcgagccag aatataattt cattggttac aagaacttta agaattttga aattactata aaagcaagat atttttataa taaagtagtc actgaggctg acgtttatat cacatttgga ataagagaag acttaaaaga tgatcaaaaa gaaatgatgc aaacagcaat gcaaaacaca atgttgataa atggaattgc tcaagtcaca tttgattctg aaacagcagt caaagaactg tcatactaca gtttagaaga tttaaacaac aagtaccttt atattgctgt aacagtcata gagtctacag gtggattttc tgaagaggca gaaatacctg gcatcaaata tgtcctctct ccctacaaac tgaatttggt tgctactcct cttttcctga agcctgggat tccatatccc atcaaggtgc aggttaaaga ttcgcttgac cagttggtag gaggagtccc agtaacactg aatgcacaaa caattgatgt aaaccaagag acatctgact tggatccaag caaaagtgta acacgtgttg atgatggagt agcttccttt gtgcttaatc tcccatctgg agtgacggtg ctggagttta atgtcaaaac tgatgctcca gatcttccag aagaaaatca ggccagggaa ggttaccgag caatagcata ctcatctctc agccaaagtt acctttatat tgattggact gataaccata aggctttgct agtgggagaa catctgaata ttattgttac ccccaaaagc ccatatattg acaaaataac tcactataat tacttgattt tatccaaggg caaaattatc cactttggca cgagggagaa attttcagat gcatcttatc aaagtataaa cattccagta acacagaaca tggttccttc atcccgactt ctggtctatt acatcgtcac aggagaacag acagcagaat tagtgtctga ttcagtctgg ttaaatattg aagaaaaatg tggcaaccag ctccaggttc atctgtctcc tgatgcagat gcatattctc caggccaaac tgtgtctctt aatatggcaa ctggaatgga ttcctgggtg gcattagcag cagtggacag tgctgtgtat ggagtccaaa gaggagccaa aaagcccttg gaaagagtat ttcaattctt agagaagagt gatctgggct gtggggcagg tggtggcctc aacaatgcca atgtgttcca cctagctgga cttaccttcc tcactaatgc aaatgcagat gactcccaag aaaatgatga accttgtaaa gaaattctca ggccaagaag aacgctgcaa aagaagatag aagaaatagc tgctaaatat aaacattcag tagtgaagaa atgttgttac gatggagcct gcgttaataa tgatgaaacc tgtgagcagc gagctgcacg gattagttta gggccaagat gcatcaaagc tttcactgaa tgttgtgtcg tcgcaagcca gctccgtgct aatatctctc ataaagacat gcaattggga aggctacaca tgaagaccct gttaccagta agcaagccag aaattcggag ttattttcca gaaagctggt tgtgggaagt tcatcttgtt cccagaagaa aacagttgca gtttgcccta cctgattctc taaccacctg ggaaattcaa ggcgttggca tttcaaacac tggtatatgt gttgctgata ctgtcaaggc aaaggtgttc aaagatgtct tcctggaaat gaatatacca tattctgttg tacgaggaga acagatccaa ttgaaaggaa ctgtttacaa ctataggact tctgggatgc agttctgtgt taaaatgtct gctgtggagg gaatctgcac ttcggaaagc ccagtcattg atcatcaggg cacaaagtcc tccaaatgtg tgcgccagaa agtagagggc tcctccagtc acttggtgac attcactgtg cttcctctgg aaattggcct tcacaacatc aatttttcac tggagacttg gtttggaaaa gaaatcttag taaaaacatt acgagtggtg ccagaaggtg tcaaaaggga aagctattct ggtgttactt tggatcctag gggtatttat ggtaccatta gcagacgaaa ggagttccca tacaggatac ccttagattt ggtccccaaa acagaaatca aaaggatttt gagtgtaaaa ggactgcttg taggtgagat cttgtctgca gttctaagtc aggaaggcat caatatccta acccacctcc ccaaagggag tgcagaggcg gagctgatga gcgttgtccc agtattctat gtttttcact acctggaaac aggaaatcat tggaacattt ttcattctga cccattaatt gaaaagcaga aactgaagaa aaaattaaaa gaagggatgt tgagcattat gtcctacaga aatgctgact actcttacag tgtgtggaag ggtggaagtg ctagcacttg gttaacagct tttgctttaa gagtacttgg acaagtaaat aaatacgtag agcagaacca aaattcaatt tgtaattctt tattgtggct agttgagaat tatcaattag ataatggatc tttcaaggaa aattcacagt atcaaccaat aaaattacag ggtaccttgc ctgttgaagc ccgagagaac agcttatatc ttacagcctt tactgtgatt ggaattagaa aggctttcga tatatgcccc ctggtgaaaa tcgacacagc tctaattaaa gctgacaact ttctgcttga aaatacactg ccagcccaga gcacctttac attggccatt tctgcgtatg ctctttccct gggagataaa actcacccac agtttcgttc aattgtttca gctttgaaga gagaagcttt ggttaaaggt aatccaccca tttatcgttt ttggaaagac aatcttcagc ataaagacag ctctgtacct aacactggta cggcacgtat ggtagaaaca actgcctatg ctttactcac cagtctgaac ttgaaagata taaattatgt taacccagtc atcaaatggc tatcagaaga gcagaggtat ggaggtggct tttattcaac ccaggacaca atcaatgcca ttgagggcct gacggaatat tcactcctgg ttaaacaact ccgcttgagt atggacatcg atgtttctta caagcataaa ggtgccttac ataattataa aatgacagac aagaatttcc ttgggaggcc agtagaggtg cttctcaatg atgacctcat tgtcagtaca ggatttggca gtggcttggc tacagtacat gtaacaactg tagttcacaa aaccagtacc tctgaggaag tttgcagctt ttatttgaaa atcgatactc aggatattga agcatcccac tacagaggct acggaaactc tgattacaaa cgcatagtag catgtgccag ctacaagccc agcagggaag aatcatcatc tggatcctct catgcggtga tggacatctc cttgcctact ggaatcagtg caaatgaaga agacttaaaa gcccttgtgg aaggggtgga tcaactattc actgattacc aaatcaaaga tggacatgtt attctgcaac tgaattcgat tccctccagt gatttccttt gtgtacgatt ccggatattt gaactctttg aagttgggtt tctcagtcct gccactttca cagtgtacga ataccacaga ccagataaac agtgtaccat gttttatagc acttccaata tcaaaattca gaaagtctgt gaaggagccg cgtgcaagtg tgtagaagct gattgtgggc aaatgcagga agaattggat ctgacaatct ctgcagagac aagaaaacaa acagcatgta aaccagagat tgcatatgct tataaagtta gcatcacatc catcactgta gaaaatgttt ttgtcaagta caaggcaacc cttctggata tctacaaaac tggggaagct gttgctgaga aagactctga gattaccttc attaaaaagg taacctgtac taacgctgag ctggtaaaag gaagacagta cttaattatg ggtaaagaag ccctccagat aaaatacaat ttcagtttca ggtacatcta ccctttagat tccttgacct ggattgaata ctggcctaga gacacaacat gttcatcgtg tcaagcattt ttagctaatt tagatgaatt tgccgaagat atctttttaa atggatgcta a

Molecular Weight

188,305 Da

OMIM

120900

Vector

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ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of C5 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for C5. It may not necessarily be applicable to this product.

NCBI GI #

109731392

NCBI GeneID

727

NCBI Accession #

BC113740

UniProt Secondary Accession #

Q14CJ0; Q27I61

UniProt Related Accession #

P01031

NCBI Official Full Name

Homo sapiens complement component 5, mRNA

NCBI Official Synonym Full Names

complement C5

NCBI Official Symbol

NCBI Official Synonym Symbols

C5D; C5a; C5b; ECLZB; CPAMD4

UniProt Protein Name

Complement C5

UniProt Synonym Protein Names

C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4

Protein Family

Complement C5

UniProt Gene Name

UniProt Synonym Gene Names

CPAMD4

UniProt Entry Name

CO5_HUMAN

NCBI Protein Information

complement C5

NCBI Summary for C5

This gene encodes a component of the complement system, a part of the innate immune system that plays an important role in inflammation, host homeostasis, and host defense against pathogens. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the C5 alpha chain, C5 beta chain, C5a anaphylatoxin and C5b. The C5 protein is comprised of the C5 alpha and beta chains, which are linked by a disulfide bridge. Cleavage of the alpha chain by a convertase enzyme results in the formation of the C5a anaphylatoxin, which possesses potent spasmogenic and chemotactic activity, and the C5b macromolecular cleavage product, a subunit of the membrane attack complex (MAC). Mutations in this gene cause complement component 5 deficiency, a disease characterized by recurrent bacterial infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]

UniProt Comments for C5

C5: Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. Defects in C5 are the cause of complement component 5 deficiency (C5D). A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. An association study of C5 haplotypes and genotypes in individuals with chronic hepatitis C virus infection shows that individuals homozygous for the C5_1 haplotype have a significantly higher stage of liver fibrosis than individuals carrying at least 1 other allele (PubMed:15995705).

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 9q33-q34

Cellular Component: extracellular region

Molecular Function: chemokine activity; protein binding; receptor binding

Biological Process: activation of MAPK activity; cell surface receptor linked signal transduction; chemotaxis; complement activation; G-protein coupled receptor protein signaling pathway; regulation of complement activation; response to stress

Disease: Complement Component 5 Deficiency; Eculizumab, Poor Response To

Research Articles on C5

1. C5 rs2269067 GG genotype confers risk for proliferative diabetic retinopathy of type 2 diabetes in Chinese Han population (associated with an elevated C5 mRNA expression and an increased IL-6 production)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with C5 cdna clone

Products by Pathway	Pathway Diagram
Activation Of C3 And C5 Pathway antibodies	Activation Of C3 And C5 Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Complement Activation, Classical Pathway antibodies	Complement Activation, Classical Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement Cascade Pathway antibodies	Complement Cascade Pathway Diagram
G Alpha (i) Signalling Events Pathway antibodies	G Alpha (i) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
Herpes Simplex Infection Pathway antibodies	Herpes Simplex Infection Pathway Diagram

Diseases associated with C5 cdna clone

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>2007 publications with C5 and Nervous System Diseases
Neurologic Manifestations Antibodies	>844 publications with C5 and Neurologic Manifestations
Inflammation Antibodies	>650 publications with C5 and Inflammation
Cardiovascular Diseases Antibodies	>590 publications with C5 and Cardiovascular Diseases
Complement component 5 deficiency Antibodies	>577 publications with C5 and Complement component 5 deficiency
Autoimmune Diseases Antibodies	>433 publications with C5 and Autoimmune Diseases
Hemolysis Antibodies	>428 publications with C5 and Hemolysis
Kidney Diseases Antibodies	>371 publications with C5 and Kidney Diseases
Necrosis Antibodies	>208 publications with C5 and Necrosis
Anemia Antibodies	>174 publications with C5 and Anemia

Organs/Tissues associated with C5 cdna clone

Organ/Tissue Name	Pubmed Publications
Bone Antibodies	>1898 publications with C5 and Bone
Muscle Antibodies	>1145 publications with C5 and Muscle
Brain Antibodies	>681 publications with C5 and Brain
Lung Antibodies	>440 publications with C5 and Lung
Kidney Antibodies	>419 publications with C5 and Kidney
Liver Antibodies	>403 publications with C5 and Liver
Spleen Antibodies	>164 publications with C5 and Spleen
Bone Marrow Antibodies	>112 publications with C5 and Bone Marrow
Intestine Antibodies	>109 publications with C5 and Intestine
Eye Antibodies	>89 publications with C5 and Eye