Human CASC3 cDNA Clone Expression Plasmid – Cat# MBS1272749

CASC3 cDNA Clone – Cancer Susceptibility Candidate 3 (Human)

Name: CASC3 cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1272749
Price: 800 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1272749

MBS1272749 is a cDNA clone targeting CASC3. More details

$800 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CASC3, cDNA Clone

Full Product Name

CASC3 cDNA Clone

Product Gene Name

CASC3 cdna clone

Sequence

atggcggacc ggcggcggca gcgcgcttcg caagacaccg aggacgagga atctggtgct tcgggctccg acagcggcgg ctccccgttg cggggaggcg ggagctgcag cggtagcgcc ggaggcggcg gcagcggctc tctgccttca cagcgcggag gccgaaccgg ggcccttcat ctgcggcggg tggagagcgg gggcgccaag agtgctgagg agtcggagtg tgagagtgaa gatggcattg aaggtgatgc tgttctctcg gattatgaaa gtgcagaaga ctcggaaggt gaagaaggtg aatacagtga agaggaaaac tccaaagtgg agctgaaatc agaagctaat gatgctgtta attcttcaac aaaagaagag aagggagaag aaaagcctga caccaaaagc actgtgactg gagagaggca aagtggggac ggacaggaga gcacagagcc tgtggagaac aaagtgggta aaaagggccc taagcatttg gatgatgatg aagatcggaa gaatccagca tacatacctc ggaaagggct cttctttgag catgatcttc gagggcaaac tcaggaggag gaagtcagac ccaaggggcg tcagcgaaag ctatggaagg atgagggtcg ctgggagcat gacaagttcc gggaagatga gcaggcccca aagtcccgac aggagctcat tgctctttat ggttatgaca ttcgctcagc tcataatcct gatgacatca aacctcgaag aatccggaaa ccccgatatg ggagtcctcc acaaagagat ccaaactgga acggtgagcg gctaaacaag tctcatcgcc accagggtct tgggggcacc ctaccaccaa ggacatttat taacaggaat gctgcaggta ccggccgtat gtctgcaccc aggaattatt ctcgatctgg gggcttcaag gaaggtcgtg ctggttttag gcctgtggaa gctggtgggc agcatggtgg ccggtctggt gagactgtta agcatgagat tagttaccgg tcacggcgcc tagagcagac ttctgtgagg gatccatctc cagaagcaga tgctccagtg cttggcagtc ctgagaagga agaggcagcc tcagagccac cagctgctgc tcctgatgct gcaccaccac cccctgatag gcccattgag aagaaatcct attcccgggc aagaagaact cgaaccaaag ttggagatgc agtcaagctt gcagaggagg tgccccctcc tcctgaagga ctgattccag cacctccagt cccagaaacc accccaactc cacctactaa gactgggacc tgggaagctc cggtggattc tagtacaagt ggacttgagc aagatgtggc acaactaaat atagcagaac agaattggag tccggggcag ccttctttcc tgcaaccacg ggaacttcga ggtatgccca accatataca catgggagca ggacctccac ctcagtttaa ccggatggaa gaaatgggtg tccagggtgg tcgagccaaa cgctattcat cccagcggca aagacctgtg ccagagcccc ccgcccctcc agtgcatatc agtatcatgg agggacatta ctatgatcca ctgcagttcc agggaccaat ctatacccat ggtgacagcc ctgccccgct gcctccacag ggcatgcttg tgcagccagg aatgaacctt ccccacccag gtttacatcc ccaccagaca ccagctcctc tgcccaatcc aggcctctat cccccaccag tgtccatgtc tccaggacag ccaccacctc agcagttgct tgctcctact tacttttctg ctccaggcgt catgaacttt ggtaatccca gttaccctta tgctccaggg gcactgcctc ccccaccacc gcctcatctg tatcctaata cacaggcccc atcacaggta tatggaggag tgacctacta taaccccgcc cagcagcagg tgcagccaaa gccctcccca ccccggagga ctccccagcc agtcaccatc aagccccctc cacctgaggt tgtaagcagg ggttccagtt aa

Molecular Weight

76,278 Da

OMIM

606504

Vector

Please Inquire

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of CASC3 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CASC3. It may not necessarily be applicable to this product.

NCBI GI #

29791618

NCBI GeneID

22794

NCBI Accession #

BC050526

UniProt Secondary Accession #

A8K8R0

UniProt Related Accession #

O15234

NCBI Official Full Name

Homo sapiens cancer susceptibility candidate 3, mRNA

NCBI Official Synonym Full Names

cancer susceptibility candidate 3

NCBI Official Symbol

CASC3

NCBI Official Synonym Symbols

BTZ; MLN51

UniProt Protein Name

Protein CASC3

UniProt Synonym Protein Names

Cancer susceptibility candidate gene 3 protein; Metastatic lymph node gene 51 protein; MLN 51; Protein barentsz; Btz

Protein Family

Protein

UniProt Gene Name

CASC3

UniProt Synonym Gene Names

MLN51; MLN 51; Btz

UniProt Entry Name

CASC3_HUMAN

NCBI Protein Information

protein CASC3

NCBI Summary for CASC3

The product of this gene is a core component of the exon junction complex (EJC), a protein complex that is deposited on spliced mRNAs at exon-exon junctions and functions in nonsense-mediated mRNA decay (NMD). The encoded protein binds RNA and interacts with two other EJC core components. It is predominantly located in the cytoplasm, but shuttles into the nucleus where it localizes to nuclear speckles. [provided by RefSeq, Jul 2008]

UniProt Comments for CASC3

CASC3: Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Core components of the EJC, that remains bound to spliced mRNAs throughout all stages of mRNA metabolism, functions to mark the position of the exon-exon junction in the mature mRNA and thereby influences downstream processes of gene expression including mRNA splicing, nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Stimulates the ATPase and RNA- helicase activities of EIF4A3. Plays a role in the stress response by participating in cytoplasmic stress granules assembly and by favoring cell recovery following stress. Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal neurons. May play a role in mRNA transport. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Binds poly(G) and poly(U) RNA homopolymer. Belongs to the CASC3 family.

Protein type: Translation; RNA-binding

Chromosomal Location of Human Ortholog: 17q21.1

Cellular Component: cytosol; nucleoplasm

Molecular Function: enzyme binding; identical protein binding; protein binding; ubiquitin protein ligase binding

Biological Process: mRNA 3'-end processing; mRNA catabolic process, nonsense-mediated decay; mRNA export from nucleus; nuclear mRNA splicing, via spliceosome; RNA export from nucleus; RNA metabolic process; termination of RNA polymerase II transcription

Research Articles on CASC3

1. MLN51, alone or as part of the EJC, interacts directly with the pivotal eukaryotic translation initiation factor eIF3

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with CASC3 cdna clone

Products by Pathway	Pathway Diagram
Exon Junction Complex (EJC) Pathway antibodies	Exon Junction Complex (EJC) Pathway Diagram
Gene Expression Pathway antibodies	Gene Expression Pathway Diagram
Nonsense Mediated Decay Enhanced By The Exon Junction Complex Pathway antibodies	Nonsense Mediated Decay Enhanced By The Exon Junction Complex Pathway Diagram
Nonsense-Mediated Decay Pathway antibodies	Nonsense-Mediated Decay Pathway Diagram
RNA Transport Pathway antibodies	RNA Transport Pathway Diagram
RNA Transport Pathway antibodies	RNA Transport Pathway Diagram
MRNA Surveillance Pathway antibodies	MRNA Surveillance Pathway Diagram
MRNA Surveillance Pathway antibodies	MRNA Surveillance Pathway Diagram

Diseases associated with CASC3 cdna clone

Disease Name	Pubmed Publications
Neoplasms Antibodies	>4 publications with CASC3 and Neoplasms
Immune System Diseases Antibodies	>3 publications with CASC3 and Immune System Diseases
Breast Neoplasms Antibodies	>3 publications with CASC3 and Breast Neoplasms
Autoimmune Diseases Antibodies	>3 publications with CASC3 and Autoimmune Diseases
Hyperplasia Antibodies	>3 publications with CASC3 and Hyperplasia
Inflammation Antibodies	>1 publications with CASC3 and Inflammation
Carcinoma Antibodies	>1 publications with CASC3 and Carcinoma

Organs/Tissues associated with CASC3 cdna clone

Organ/Tissue Name	Pubmed Publications
Lymph Antibodies	>5 publications with CASC3 and Lymph
Lymph Node Antibodies	>5 publications with CASC3 and Lymph Node
Brain Antibodies	>3 publications with CASC3 and Brain
Amniotic Fluid Antibodies	>1 publications with CASC3 and Amniotic Fluid
Lung Antibodies	>1 publications with CASC3 and Lung
Embryonic Tissue Antibodies	>1 publications with CASC3 and Embryonic Tissue
Muscle Antibodies	>1 publications with CASC3 and Muscle
Stomach Antibodies	>1 publications with CASC3 and Stomach