Human CCM2 cDNA Clone Expression Plasmid – Cat# MBS1267695

CCM2 cDNA Clone – Cerebral Cavernous Malformation 2 (Human)

Name: CCM2 cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1267695
Price: 235 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1267695

MBS1267695 is a cDNA clone targeting CCM2. More details

$235 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CCM2, cDNA Clone

Full Product Name

CCM2 cDNA Clone

Product Gene Name

CCM2 cdna clone

Sequence

atggaagagg agggcaagaa gggcaagaag cctggaattg tctcgccatt taaacgagta ttcctaaaag gtgaaaagag tagagataag aaagcccatg agaaggtgac agagaggcgc cctctgcaca ctgtggtgtt gtcattgcct gagcgcgtcg agccagacag actgctgagc gactatattg agaaggaggt aaagtattta ggtcagttaa cgtccatacc aggatacctg aatccctcca gtaggactga aatcctgcat ttcatagaca atgcaaagag agcccaccag cttccgggac acttgactca ggagcacgat gctgtgctca gcctgtctgc gtacaacgtc aagctggcct ggagggacgg ggaggatatc atcctcaggg tgcccatcca tgacatcgcc gccgtctcct atgttcggga tgacgctgca cacctggtgg tcctgaagac agcccaggac ccagggatct cccccagcca gagtctgtgt gcggaaagtt ccagaggcct cagtgcaggc tccctgtcgg agagtgcagt tgggcccgtg gaggcatgct gcctggtcat cctggctgca gagagcaagg tcgctgcgga ggagctttgc tgtctgctag gccaggtctt ccaggttgtt tacacggagt ccaccatcga ctttctggac agagcgatat ttgatggggc ctctaccccg acccaccacc tgtccctgca cagcgatgac tcttctacaa aagtggacat taaggagacc tacgaggtgg aagccagcac tttctgcttc cctgaatctg tggatgtggg tggtgcatca ccccacagca agaccatcag tgagagcgag ctgagcgcca gcgccactga gctgctgcag gactacatgc tgacgctgcg caccaagctg tcatcacagg agatccagca gtttgcagca ctgctgcacg agtaccgcaa tggggcctct atccacgagt tctgcatcaa cctgcggcag ctctacgggg acagccgcaa gttcctgctg cttggtctga ggcccttcat ccctgagaag gacagccagc acttcgagaa cttcctggag accattggcg tgaaggatgg ccgcggcatc atcactgaca gctttggcag gcaccggcgg gccctgagca ccacatccag ttccaccacc aatgggaaca gggccacggg cagctctgat gaccggtcgg caccctcaga gggggatgag tgggaccgca tgatctcgga catcagcagc gacattgagg cgctgggctg cagcatggac caggactcag catga

Molecular Weight

42,073 Da

OMIM

603284

Vector

pENTR223.1 or pUC

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of CCM2 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CCM2. It may not necessarily be applicable to this product.

NCBI GI #

33870299

NCBI GeneID

83605

NCBI Accession #

BC004903

UniProt Secondary Accession #

Q71RE5; Q8TAT4; A4D2L4; B3KUV0; D3DVL4; E9PDJ3; F5H0E1; F5H551

UniProt Related Accession #

Q9BSQ5

NCBI Official Full Name

Homo sapiens cerebral cavernous malformation 2, mRNA

NCBI Official Synonym Full Names

CCM2 scaffolding protein

NCBI Official Symbol

CCM2

NCBI Official Synonym Symbols

OSM; C7orf22; PP10187

UniProt Protein Name

Cerebral cavernous malformations 2 protein

UniProt Synonym Protein Names

Malcavernin

Protein Family

Cerebral cavernous malformations 2 protein

UniProt Gene Name

CCM2

UniProt Synonym Gene Names

C7orf22

UniProt Entry Name

CCM2_HUMAN

NCBI Protein Information

cerebral cavernous malformations 2 protein

NCBI Summary for CCM2

This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2009]

UniProt Comments for CCM2

CCM2: Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions. May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3- dependent p38 activation induced by hyperosmotic shock. Defects in CCM2 are the cause of cerebral cavernous malformations type 2 (CCM2). Cerebral cavernous malformations (CCMs) are congenital vascular anomalies of the central nervous system that can result in hemorrhagic stroke, seizures, recurrent headaches, and focal neurologic deficits. CCMs have an incidence of 0.1%-0.5% in the general population and are usually present clinically during the 3rd to 5th decades of life. The lesions are characterized by grossly enlarged blood vessels consisting of a single layer of endothelium and without any intervening neural tissue, ranging in diameter from a few millimeters to several centimeters. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 7p13

Cellular Component: cytoplasm

Molecular Function: protein binding

Biological Process: integrin-mediated signaling pathway; stress-activated MAPK cascade; vasculogenesis

Disease: Cerebral Cavernous Malformations 2

Research Articles on CCM2

1. Studies suggest that the 3 proteins of the Cerebral Cavernous Malformations (CCM) complex KRIT1/CCM1, CCM2/malcavernin and CCM3/PDCD10 not only require one another for reciprocal stabilization, but also act as a platform for signal transduction.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with CCM2 cdna clone

Products by Pathway	Pathway Diagram
Regulation Of P38-alpha And P38-beta Pathway antibodies	Regulation Of P38-alpha And P38-beta Pathway Diagram
P38 MAPK Signaling Pathway antibodies	P38 MAPK Signaling Pathway Diagram

Diseases associated with CCM2 cdna clone

Disease Name	Pubmed Publications
Vascular Malformations Antibodies	>104 publications with CCM2 and Vascular Malformations
Hemangioma, Cavernous, Central Nervous System Antibodies	>64 publications with CCM2 and Hemangioma, Cavernous, Central Nervous System
Cerebral Cavernous Malformations 2 Antibodies	>55 publications with CCM2 and Cerebral Cavernous Malformations 2
Hemorrhage Antibodies	>23 publications with CCM2 and Hemorrhage
Disease Models, Animal Antibodies	>13 publications with CCM2 and Disease Models, Animal
Abnormalities, Multiple Antibodies	>6 publications with CCM2 and Abnormalities, Multiple
Heart Defects, Congenital Antibodies	>2 publications with CCM2 and Heart Defects, Congenital
Edema Antibodies	>2 publications with CCM2 and Edema
Atrophy Antibodies	>1 publications with CCM2 and Atrophy
Ovarian Diseases Antibodies	>1 publications with CCM2 and Ovarian Diseases

Organs/Tissues associated with CCM2 cdna clone

Organ/Tissue Name	Pubmed Publications
Vascular Antibodies	>90 publications with CCM2 and Vascular
Brain Antibodies	>56 publications with CCM2 and Brain
Blood Antibodies	>40 publications with CCM2 and Blood
Heart Antibodies	>11 publications with CCM2 and Heart
Embryonic Tissue Antibodies	>7 publications with CCM2 and Embryonic Tissue
Skin Antibodies	>5 publications with CCM2 and Skin
Muscle Antibodies	>5 publications with CCM2 and Muscle
Bone Antibodies	>2 publications with CCM2 and Bone
Testis Antibodies	>1 publications with CCM2 and Testis
Liver Antibodies	>1 publications with CCM2 and Liver