CDKN2D cDNA Clone – Cyclin-Dependent Kinase Inhibitor 2d (P19, Inhibits CDK4) (Human)

The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis. Two alternatively spliced variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008]

CDKN2D: Interacts strongly with CDK4 and CDK6 and inhibits them. Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.

Protein type: Inhibitor; Cell cycle regulation; Tumor suppressor

Chromosomal Location of Human Ortholog: 19p13

Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus

Molecular Function: cyclin-dependent protein kinase inhibitor activity; protein binding; protein kinase binding

Biological Process: autophagic cell death; cell cycle arrest; DNA synthesis during DNA repair; G1/S transition of mitotic cell cycle; negative regulation of caspase activity; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of phosphorylation; regulation of cyclin-dependent protein kinase activity; response to retinoic acid; response to UV; response to vitamin D