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CHML cDNA Clone – Choroideremia-Like (Rab Escort Protein 2) (Human)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1276733

MBS1276733 is a cDNA clone targeting CHML. More details

$400 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CHML, cDNA Clone
Full Product Name
CHML cDNA Clone
Product Gene Name
CHML cdna clone
Sequence
atggcggaca atcttcccac agagtttgat gtggttataa tagggacagg tttgcccgaa tccatccttg cagctgcatg ttcaagaagt ggtcagaggg ttctgcatat tgattcaaga agctactatg gaggaaactg ggctagtttc agcttttcag gattgctatc ctggttgaag gagtatcagc aaaacaatga cattggggaa gaaagtactg ttgtatggca ggacctgatc catgaaacag aagaagccat cactcttcgc aagaaggatg aaactattca acacacagaa gctttttgct acgccagtca ggatatggag gacaacgttg aagagattgg tgctctgcag aaaaatcctt ctttgggggt gtctaatacc ttcactgaag ttctggattc tgcattacct gaagaaagcc agttatcgta ttttaatagc gacgaaatgc ctgcaaaaca cactcagaaa agtgatacag agatttcact agaagtaact gatgtagagg aatcagtgga gaaggaaaag tattgtggag ataaaacttg tatgcacaca gtttcagata aagatggaga taaagatgaa agcaaatcta cagtagaaga taaggccgat gaaccaatta gaaataggat tacttactct caaatagtta aagaaggcag gaggtttaat attgatttgg tgtcaaaact gctgtattct caaggattgc taattgatct tttaatcaaa tcagatgtta gtcgttatgt agaatttaaa aatgtcacta ggattcttgc atttcgggaa ggaaaggtag aacaagttcc ttgttccaga gcagatgtct ttaatagcaa ggaactcacc atggttgaaa agaggatgct aatgaaattt ctcacatttt gtttagagta tgaacaacat cctgatgaat accaagcttt caggcagtgt tcattttcag aatacttaaa aactaaaaaa ctaactccca accttcaaca ttttgtactg cactcaattg caatgacatc agaatcatct tgcactacaa tagatggtct taacgcaact aaaaacttcc ttcagtgtct cggacggttt ggcaacaccc cctttttatt tcccttgtat ggccaaggag aaattcccca gggtttctgt aggatgtgtg cagtttttgg tggaatctat tgtcttcgtc ataaagtaca atgctttgta gtcgacaaag aatctggacg atgtaaagca attatagatc actttggtca aagaataaat gctaaatatt ttattgtgga agacagttac ctttctgagg aaacatgctc aaatgtgcag tataagcaga tctctagggc agtactcatt acagatcagt ctatactaaa gacagattta gatcagcaga cttccattct gatagttcct ccagcagagc caggagcttg tgctgtacgg gtcacagaat tatgttcttc aaccatgaca tgcatgaagg acacctatct ggtacatttg acatgttcat cttctaaaac agcaagagaa gacttagaat cagtggtgaa gaaattattc actccgtata ctgaaacaga aataaacgag gaagaactta caaagccaag actcttgtgg gctctttatt ttaatatgag agattcctcg ggaatcagca gaagctcgta taatggcttg ccttccaatg tttatgtctg ctctgggcct gactgtggcc tgggaaatga gcatgctgtc aagcaagctg aaacactttt ccaggagatc tttccaactg aagaattctg ccctccacct ccaaatccag aagacattat ctttgatggt gatgataagc agccagaggc tcctggaacc aataatgtag taatggccaa actagaatcc tctgaggaaa gcaaaaacct agaaagccca gagaagcacc ttcaaaatta g
Molecular Weight
74,071 Da
OMIM
118825
Vector
pENTR223.1 or pUC
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of CHML cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CHML. It may not necessarily be applicable to this product.

NCBI GI #
109658885
NCBI GeneID
1122
NCBI Accession #
BC117360
UniProt Secondary Accession #
Q17RE0; Q9H1Y4; B2RAB9
UniProt Related Accession #
P26374
NCBI Official Full Name
Homo sapiens choroideremia-like (Rab escort protein 2), mRNA
NCBI Official Synonym Full Names
CHM like, Rab escort protein 2
NCBI Official Symbol
CHML
NCBI Official Synonym Symbols
REP2
UniProt Protein Name
Rab proteins geranylgeranyltransferase component A 2
UniProt Synonym Protein Names
Choroideremia-like protein; Rab escort protein 2; REP-2
Protein Family
Rab proteins geranylgeranyltransferase component
UniProt Gene Name
CHML
UniProt Synonym Gene Names
REP2; REP-2
UniProt Entry Name
RAE2_HUMAN
NCBI Protein Information
rab proteins geranylgeranyltransferase component A 2

NCBI Summary for CHML

The product of the CHML gene supports geranylgeranylation of most Rab proteins and may substitute for REP-1 in tissues other than retina. CHML is localized close to the gene for Usher syndrome type II. [provided by RefSeq, Jul 2008]

UniProt Comments for CHML

CHML: Binds unprenylated Rab proteins, presents it to the catalytic Rab GGTase dimer, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Less effective than REP-1 in supporting prenylation of Rab3 family. Belongs to the Rab GDI family.

Chromosomal Location of Human Ortholog: 1q43

Cellular Component: cytoplasm; nucleoplasm; Rab-protein geranylgeranyltransferase complex

Molecular Function: Rab GTPase binding

Biological Process: protein geranylgeranylation
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Research Articles on CHML

1. Polymorphisms in the OPN3 and CHML genes are associated with asthma and atopic asthma.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with CHML cdna clone

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >4 publications with CHML and Neoplasms
 Drug Toxicity Antibodies  >2 publications with CHML and Drug Toxicity
 Immune System Diseases Antibodies  >2 publications with CHML and Immune System Diseases
 Skin Neoplasms Antibodies  >1 publications with CHML and Skin Neoplasms
 Liver Neoplasms Antibodies  >1 publications with CHML and Liver Neoplasms
 Fatty Liver Antibodies  >1 publications with CHML and Fatty Liver
 Carcinoma, Hepatocellular Antibodies  >1 publications with CHML and Carcinoma, Hepatocellular
 Liver Diseases Antibodies  >1 publications with CHML and Liver Diseases
 Nervous System Diseases Antibodies  >1 publications with CHML and Nervous System Diseases
 Hematologic Diseases Antibodies  >1 publications with CHML and Hematologic Diseases

Organs/Tissues associated with CHML cdna clone

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >4 publications with CHML and Skin
 Eye Antibodies  >4 publications with CHML and Eye
 Lung Antibodies  >3 publications with CHML and Lung
 Liver Antibodies  >2 publications with CHML and Liver
 Brain Antibodies  >2 publications with CHML and Brain
 Testis Antibodies  >1 publications with CHML and Testis
 Kidney Antibodies  >1 publications with CHML and Kidney
 Bladder Antibodies  >1 publications with CHML and Bladder
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