Human CHRM3 cDNA Clone Expression Plasmid – Cat# MBS1267430

CHRM3 cDNA Clone – Cholinergic Receptor, Muscarinic 3 (Human)

Name: CHRM3 cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1267430
Price: 400 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1267430

MBS1267430 is a cDNA clone targeting CHRM3. More details

$400 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CHRM3, cDNA Clone

Full Product Name

CHRM3 cDNA Clone

Product Gene Name

CHRM3 cdna clone

Sequence

ATGACCTTGC ACAATAACAG TACAACCTCG CCTTTGTTTC CAAACATCAG CTCCTCCTGG ATACACAGCC CCTCCGATGC AGGGCTGCCC CCGGGAACCG TCACTCATTT CGGCAGCTAC AATGTTTCTC GAGCAGCTGG CAATTTCTCC TCTCCAGACG GTACCACCGA TGACCCTCTG GGAGGTCATA CCGTCTGGCA AGTGGTCTTC ATCGCTTTCT TAACGGGCAT CCTGGCCTTG GTGACCATCA TCGGCAACAT CCTGGTAATT GTGTCATTTA AGGTCAACAA GCAGCTGAAG ACGGTCAACA ACTACTTCCT CTTAAGCCTG GCCTGTGCCG ATCTGATTAT CGGGGTCATT TCAATGAATC TGTTTACGAC CTACATCATC ATGAATCGAT GGGCCTTAGG GAACTTGGCC TGTGACCTCT GGCTTGCCAT TGACTACGTA GCCAGCAATG CCTCTGTTAT GAATCTTCTG GTCATCAGCT TTGACAGATA CTTTTCCATC ACGAGGCCGC TCACGTACCG AGCCAAACGA ACAACAAAGA GAGCCGGTGT GATGATCGGT CTGGCTTGGG TCATCTCCTT TGTCCTTTGG GCTCCTGCCA TCTTGTTCTG GCAATACTTT GTTGGAAAGA GAACTGTGCC TCCGGGAGAG TGCTTCATTC AGTTCCTCAG TGAGCCCACC ATTACTTTTG GCACAGCCAT CGCTGCTTTT TATATGCCTG TCACCATTAT GACTATTTTA TACTGGAGGA TCTATAAGGA AACTGAAAAG CGTACCAAAG AGCTTGCTGG CCTGCAAGCC TCTGGGACAG AGGCAGAGAC AGAAAACTTT GTCCACCCCA CGGGCAGTTC TCGAAGCTGC AGCAGTTACG AACTTCAACA GCAAAGCATG AAACGCTCCA ACAGGAGGAA GTATGGCCGC TGCCACTTCT GGTTCACAAC CAAGAGCTGG AAACCCAGCT CCGAGCAGAT GGACCAAGAC CACAGCAGCA GTGACAGTTG GAACAACAAT GATGCTGCTG CCTCCCTGGA GAACTCCGCC TCCTCCGACG AGGAGGACAT TGGCTCCGAG ACGAGAGCCA TCTACTCCAT CGTGCTCAAG CTTCCGGGTC ACAGCACCAT CCTCAACTCC ACCAAGTTAC CCTCATCGGA CAACCTGCAG GTGCCTGAGG AGGAGCTGGG GATGGTGGAC TTGGAGAGGA AAGCCGACAA GCTGCAGGCC CAGAAGAGCG TGGACGATGG AGGCAGTTTT CCAAAAAGCT TCTCCAAGCT TCCCATCCAG CTAGAGTCAG CCGTGGACAC AGCTAAGACT TCTGACGTCA ACTCCTCAGT GGGTAAGAGC ACGGCCACTC TACCTCTGTC CTTCAAGGAA GCCACTCTGG CCAAGAGGTT TGCTCTGAAG ACCAGAAGTC AGATCACTAA GCGGAAAAGG ATGTCCCTGG TCAAGGAGAA GAAAGCGGCC CAGACCCTCA GTGCGATCTT GCTTGCCTTC ATCATCACTT GGACCCCATA CAACATCATG GTTCTGGTGA ACACCTTTTG TGACAGCTGC ATACCCAAAA CCTTTTGGAA TCTGGGCTAC TGGCTGTGCT ACATCAACAG CACCGTGAAC CCCGTGTGCT ATGCTCTGTG CAACAAAACA TTCAGAACCA CTTTCAAGAT GCTGCTGCTG TGCCAGTGTG ACAAAAAAAA GAGGCGCAAG CAGCAGTACC AGCAGAGACA GTCGGTCATT TTTCACAAGC GCGCACCCGA GCAGGCCTTG TAG

Molecular Weight

66,128 Da

OMIM

100100

Vector

pENTR223.1 or pUC

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of CHRM3 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CHRM3. It may not necessarily be applicable to this product.

NCBI GI #

115528527

NCBI GeneID

1131

NCBI Accession #

BC121026

UniProt Secondary Accession #

Q0VAJ8; Q4QRI3; Q5VXY2; Q9HB60

UniProt Related Accession #

P20309

NCBI Official Full Name

Homo sapiens cholinergic receptor, muscarinic 3, mRNA

NCBI Official Synonym Full Names

cholinergic receptor muscarinic 3

NCBI Official Symbol

CHRM3

NCBI Official Synonym Symbols

HM3; PBS; EGBRS

UniProt Protein Name

Muscarinic acetylcholine receptor M3

Protein Family

Muscarinic acetylcholine receptor

UniProt Gene Name

CHRM3

UniProt Entry Name

ACM3_HUMAN

NCBI Protein Information

muscarinic acetylcholine receptor M3

NCBI Summary for CHRM3

The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 3 controls smooth muscle contraction and its stimulation causes secretion of glandular tissue. [provided by RefSeq, Jul 2008]

UniProt Comments for CHRM3

mAChR M3: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. Defects in CHRM3 are the cause of Eagle-Barrett syndrome (EGBRS). EGBRS is a syndrome characterized by thin abdominal musculature with overlying lax skin, cryptorchism, megacystis with disorganized detrusor muscle, and urinary tract abnormalities. Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM3 sub-subfamily.

Protein type: Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q43

Cellular Component: integral to plasma membrane; plasma membrane; synapse

Molecular Function: acetylcholine binding; G-protein coupled acetylcholine receptor activity; phosphoinositide phospholipase C activity; protein binding; receptor activity

Biological Process: acetylcholine receptor signaling, muscarinic pathway; cell proliferation; G-protein coupled receptor protein signaling pathway; muscarinic acetylcholine receptor, adenylate cyclase inhibiting pathway; muscarinic acetylcholine receptor, phospholipase C activating pathway; nervous system development; protein modification process; regulation of vascular smooth muscle contraction; signal transduction; synaptic transmission, cholinergic

Disease: Abdominal Muscles, Absence Of, With Urinary Tract Abnormality And Cryptorchidism

Research Articles on CHRM3

1. Blockading CHRM3 by shRNA or treatment with darifenacin inhibited prostate cancer growth.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with CHRM3 cdna clone

Products by Pathway	Pathway Diagram
Amine Ligand-binding Receptors Pathway antibodies	Amine Ligand-binding Receptors Pathway Diagram
Calcium Regulation In The Cardiac Cell Pathway antibodies	Calcium Regulation In The Cardiac Cell Pathway Diagram
Calcium Signaling Pathway antibodies	Calcium Signaling Pathway Diagram
Calcium Signaling Pathway antibodies	Calcium Signaling Pathway Diagram
Cholinergic Synapse Pathway antibodies	Cholinergic Synapse Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
G Alpha (q) Signalling Events Pathway antibodies	G Alpha (q) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
GPCRs, Class A Rhodopsin-like Pathway antibodies	GPCRs, Class A Rhodopsin-like Pathway Diagram

Diseases associated with CHRM3 cdna clone

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>5 publications with CHRM3 and Nervous System Diseases
Inflammation Antibodies	>3 publications with CHRM3 and Inflammation
Seizures Antibodies	>2 publications with CHRM3 and Seizures
Kidney Diseases Antibodies	>2 publications with CHRM3 and Kidney Diseases
Movement Disorders Antibodies	>1 publications with CHRM3 and Movement Disorders
Hyperplasia Antibodies	>1 publications with CHRM3 and Hyperplasia
Poisoning Antibodies	>1 publications with CHRM3 and Poisoning
Hypertension Antibodies	>1 publications with CHRM3 and Hypertension
Pain Antibodies	>1 publications with CHRM3 and Pain
Ascites Antibodies	>1 publications with CHRM3 and Ascites

Organs/Tissues associated with CHRM3 cdna clone

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>4 publications with CHRM3 and Brain
Eye Antibodies	>2 publications with CHRM3 and Eye
Mixed Antibodies	>1 publications with CHRM3 and Mixed
Testis Antibodies	>1 publications with CHRM3 and Testis
Intestine Antibodies	>1 publications with CHRM3 and Intestine
Connective Tissue Antibodies	>1 publications with CHRM3 and Connective Tissue