Human CSE1L cDNA Clone Expression Plasmid – Cat# MBS1267001

CSE1L cDNA Clone – CSE1 Chromosome Segregation 1-Like (Yeast) (Human)

Name: CSE1L cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1267001
Price: 630 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1267001

MBS1267001 is a cDNA clone targeting CSE1L. More details

$630 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CSE1L, cDNA Clone

Full Product Name

CSE1L cDNA Clone

Product Gene Name

CSE1L cdna clone

Sequence

ATGGAACTCA GCGATGCAAA TCTGCAAACA CTAACAGAAT ATTTAAAGAA AACACTTGAT CCTGATCCTG CCATCCGACG TCCAGCTGAG AAATTTCTTG AATCTGTTGA AGGAAATCAG AATTATCCAC TGTTGCTTTT GACATTACTG GAGAAGTCCC AGGATAATGT TATCAAAGTA TGTGCTTCAG TAACATTCAA AAACTATATT AAAAGGAACT GGAGAATTGT TGAAGATGAA CCAAACAAAA TTTGTGAAGC CGATCGAGTG GCCATTAAAG CCAACATAGT GCACTTGATG CTTAGCAGCC CAGAGCAAAT TCAGAAGCAG TTAAGTGATG CAATTAGCAT TATTGGCAGA GAAGATTTTC CACAGAAATG GCCTGACTTG CTGACAGAAA TGGTGAATCG CTTTCAGAGT GGAGATTTCC ATGTTATTAA TGGAGTCCTC CGTACAGCAC ATTCATTATT TAAAAGATAC CGTCATGAAT TTAAGTCAAA CGAGTTATGG ACTGAAATTA AGCTTGTTCT GGATGCCTTT GCTTTGCCTT TGACTAATCT TTTTAAGGCC ACTATTGAAC TCTGCAGTAC CCATGCAAAT GATGCCTCTG CCCTGAGGAT TCTGTTTTCT TCCCTGATCC TGATCTCAAA ATTGTTCTAT AGTTTAAACT TTCAGGATCT CCCTGAATTT TTTGAAGATA ATATGGAAAC TTGGATGAAT AATTTTCATA CTCTCTTAAC ATTGGATAAT AAGCTTTTAC AAACTGATGA TGAAGAGGAA GCCGGCTTAT TGGAGCTCTT AAAATCCCAG ATTTGTGATA ATGCCGCACT CTATGCACAA AAGTACGATG AAGAATTCCA GCGATACCTG CCTCGTTTTG TTACAGCCAT CTGGAATTTA CTAGTTACAA CGGGTCAAGA GGTTAAATAT GATTTGTTGG TAAGTAATGC AATTCAATTT CTGGCTTCAG TTTGTGAGAG ACCTCATTAT AAGAATCTAT TTGAGGACCA GAACACGCTG ACAAGTATCT GTGAAAAGGT TATTGTGCCT AACATGGAAT TTAGAGCTGC TGATGAAGAA GCATTTGAAG ATAATTCTGA GGAGTACATA AGGAGAGATT TGGAAGGATC TGATATTGAT ACTAGACGCA GGGCTGCTTG TGATCTGGTA CGAGGATTAT GCAAGTTTTT TGAGGGACCT GTGACAGGAA TCTTCTCTGG TTATGTTAAT TCCATGCTGC AGGAATACGC AAAAAATCCA TCTGTCAACT GGAAACACAA AGATGCAGCC ATCTACCTAG TGACATCTTT GGCATCAAAA GCCCAAACAC AGAAGCATGG AATTACACAA GCAAATGAAC TTGTAAACCT AACTGAGTTC TTTGTGAATC ACATCCTCCC TGATTTAAAA TCAGCTAATG TGAATGAATT TCCTGTCCTT AAAGCTGACG GTATCAAATA TATTATGATT TTTAGAAATC AAGTGCCAAA AGAACATCTT TTAGTCTCGA TTCCTCTCTT GATTAATCAT CTTCAAGCTG AAAGTATTGT TGTTCATACT TACGCAGCTC ATGCTCTTGA ACGGCTCTTT ACTATGCGAG GGCCTAACAA TGCCACTCTC TTTACAGCTG CAGAAATCGC ACCGTTTGTT GAGATTCTGC TAACAAACCT TTTCAAAGCT CTCACACTTC CTGGCTCTTC AGAAAATGAA TATATTATGA AAGCTATCAT GAGAAGTTTT TCTCTCCTAC AAGAAGCCAT AATCCCCTAC ATCCCTACTC TCATCACTCA GCTTACACAG AAGCTATTAG CTGTTAGTAA GAACCCAAGC AAACCTCACT TTAATCACTA CATGTTTGAA GCAATATGTT TATCCATAAG AATAACTTGC AAAGCTAACC CTGCTGCTGT TGTAAATTTT GAGGAGGCTT TGTTTTTGGT GTTTACTGAA ATCTTACAAA ATGATGTGCA AGAATTTATT CCATACGTCT TTCAAGTGAT GTCTTTGCTT CTGGAAACAC ACAAAAATGA CATCCCGTCT TCCTATATGG CCTTATTTCC TCATCTCCTT CAGCCAGTGC TTTGGGAAAG AACAGGAAAT ATTCCTGCTC TAGTGAGGCT TCTTCAAGCA TTCTTAGAAC GCGGTTCAAA CACAATAGCA AGTGCTGCAG CTGACAAAAT TCCTGGGTTA CTAGGTGTCT TTCAGAAGCT GATTGCATCC AAAGCAAATG ACCACCAAGG TTTTTATCTT CTAAACAGTA TAATAGAGCA CATGCCTCCT GAATCAGTTG ACCAATATAG GAAACAAATC TTCATTCTGC TATTCCAGAG ACTTCAGAAT TCCAAAACAA CCAAGTTTAT CAAGAGTTTT TTAGTCTTTA TTAATTTGTA TTGCATAAAA TATGGGGCAC TAGCACTACA AGAAATATTT GATGGTATAC AACCAAAAAT GTTTGGAATG GTTTTGGAAA AAATTATTAT TCCTGAAATT CAGAAGGTAT CTGGAAATGT AGAGAAAAAG ATCTGTGCGG TTGGCATAAC CAAATTACTA ACAGAATGTC CCCCAATGAT GGACACTGAG TATACCAAAC TGTGGACTCC ATTATTACAG TCTTTGATTG GTCTTTTTGA GTTACCCGAA GATGATACCA TTCCTGATGA GGAACATTTT ATTGACATAG AAGATACACC AGGATATCAG ACTGCCTTCT CACAGTTGGC ATTTGCTGGG AAAAAAGAGC ATGATCCTGT AGGTCAAATG GTGAATAACC CCAAAATTCA CCTGGCACAG TCACTTCACA AGTTGTCTAC CGCCTGTCCA GGAAGGGTTC CATCAATGGT GAGCACCAGC CTGAATGCAG AAGCGCTCCA GTATCTCCAA GGGTACCTTC AGGCAGCCAG TGTGACACTG CTTTAA

Molecular Weight

103,879 Da

OMIM

601342

Vector

pENTR223.1 or pUC

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of CSE1L cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CSE1L. It may not necessarily be applicable to this product.

NCBI GI #

115344434

NCBI GeneID

1434

NCBI Accession #

BC109313

UniProt Secondary Accession #

O75432; Q32M40; Q9H5B7; Q9NTS0; Q9UP98; Q9UP99; Q9UPA0; A3RLL6; B2R5T4; E1P5Y0; F8W904

UniProt Related Accession #

P55060

NCBI Official Full Name

Homo sapiens CSE1 chromosome segregation 1-like (yeast), mRNA

NCBI Official Synonym Full Names

chromosome segregation 1 like

NCBI Official Symbol

CSE1L

NCBI Official Synonym Symbols

CAS; CSE1; XPO2

UniProt Protein Name

Exportin-2

UniProt Synonym Protein Names

Cellular apoptosis susceptibility protein; Chromosome segregation 1-like protein; Importin-alpha re-exporter

UniProt Gene Name

CSE1L

UniProt Synonym Gene Names

CAS; XPO2; Exp2

UniProt Entry Name

XPO2_HUMAN

NCBI Protein Information

exportin-2

NCBI Summary for CSE1L

Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]

UniProt Comments for CSE1L

Exportin-2: Export receptor for importin-alpha. Mediates importin- alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Belongs to the XPO2/CSE1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear import; Nuclear export; Karyopherin

Chromosomal Location of Human Ortholog: 20q13

Cellular Component: cytoplasm; cytosol; membrane; nuclear envelope; nucleoplasm; nucleus

Molecular Function: nuclear export signal receptor activity; protein binding

Biological Process: apoptosis; cell proliferation; protein import into nucleus

Research Articles on CSE1L

1. There is a relationship between nuclear CSE1L overexpression and distant metastasis in breast cancer.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with CSE1L cdna clone

Products by Pathway	Pathway Diagram
Direct P53 Effectors Pathway antibodies	Direct P53 Effectors Pathway Diagram
P53 Pathway antibodies	P53 Pathway Diagram

Diseases associated with CSE1L cdna clone

Disease Name	Pubmed Publications
Neoplasms Antibodies	>34 publications with CSE1L and Neoplasms
Breast Neoplasms Antibodies	>6 publications with CSE1L and Breast Neoplasms
Neoplasm Metastasis Antibodies	>6 publications with CSE1L and Neoplasm Metastasis
Neoplasms, Experimental Antibodies	>5 publications with CSE1L and Neoplasms, Experimental
Liver Diseases Antibodies	>4 publications with CSE1L and Liver Diseases
Carcinoma, Hepatocellular Antibodies	>3 publications with CSE1L and Carcinoma, Hepatocellular
Liver Neoplasms Antibodies	>3 publications with CSE1L and Liver Neoplasms
Nervous System Diseases Antibodies	>3 publications with CSE1L and Nervous System Diseases
Inflammation Antibodies	>2 publications with CSE1L and Inflammation
Skin Neoplasms Antibodies	>2 publications with CSE1L and Skin Neoplasms

Organs/Tissues associated with CSE1L cdna clone

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>5 publications with CSE1L and Liver
Blood Antibodies	>5 publications with CSE1L and Blood
Lymph Node Antibodies	>4 publications with CSE1L and Lymph Node
Lymph Antibodies	>4 publications with CSE1L and Lymph
Brain Antibodies	>4 publications with CSE1L and Brain
Intestine Antibodies	>3 publications with CSE1L and Intestine
Bladder Antibodies	>3 publications with CSE1L and Bladder
Kidney Antibodies	>2 publications with CSE1L and Kidney
Skin Antibodies	>2 publications with CSE1L and Skin
Vascular Antibodies	>2 publications with CSE1L and Vascular