Human CTCF cDNA Clone Expression Plasmid – Cat# MBS1270296

CTCF cDNA Clone – CCCTC-Binding Factor (Zinc Finger Protein) (Human)

Name: CTCF cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1270296
Price: 520 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1270296

MBS1270296 is a cDNA clone targeting CTCF. More details

$520 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CTCF, cDNA Clone

Full Product Name

CTCF cDNA Clone

Product Gene Name

CTCF cdna clone

Sequence

atggaaggtg atgcagtcga agccattgtg gaggagtccg aaacttttat taaaggaaag gagagaaaga cttaccagag acgccgggaa gggggccagg aagaagatgc ctgccactta ccccagaacc agacggatgg gggtgaggtg gtccaggatg tcaacagcag tgtacagatg gtgatgatgg aacagctgga ccccaccctt cttcagatga agactgaagt aatggagggc acagtggctc cagaagcaga ggctgctgtg gacgataccc agattataac tttacaggtt gtaaatatgg aggaacagcc cataaacata ggagaacttc agcttgttca agtacctgtt cctgtgactg tacctgttgc taccacttca gtagaagaac ttcagggggc ttatgaaaat gaagtgtcta aagagggcct tgcggaaagt gaacccatga tatgccacac cctacctttg cctgaagggt ttcaggtggt taaagtgggg gccaatggag aggtggagac actagaacaa ggggaacttc caccccagga agatcctagt tggcaaaaag acccagacta tcagccacca gccaaaaaaa caaagaaaac caaaaagagc aaactgcgtt atacagagga gggcaaagat gtagatgtgt ctgtctacga ttttgaggaa gaacagcagg agggtctgct atcagaggtt aatgcagaga aagtggttgg taatatgaag cctccaaagc caacaaaaat taaaaagaaa ggtgtaaaga agacattcca gtgtgagctt tgcagttaca cgtgtccacg gcgttcaaat ttggatcgtc acatgaaaag ccacactgat gagagaccac acaagtgcca tctctgtggc agggcattca gaacagtcac cctcctgagg aatcacctta acacacacac aggtactcgt cctcacaagt gcccagactg cgacatggcc tttgtgacca gtggagaatt ggttcggcat cgtcgttaca aacacaccca cgagaagcca ttcaagtgtt ccatgtgcga ttacgccagt gtagaagtca gcaaattaaa acgtcacatt cgctctcata ctggagagcg tccgtttcag tgcagtttgt gcagttatgc cagcagggac acatacaagc tgaaaaggca catgagaacc cattcagggg aaaagcctta tgaatgttat atttgtcatg ctcggtttac ccaaagtggt accatgaaga tgcacatttt acagaagcac acagaaaatg tggccaaatt tcactgtccc cactgtgaca cagtcatagc ccgaaaaagt gatttgggtg tccacttgcg aaagcagcat tcctatattg agcaaggcaa gaaatgccgt tactgtgatg ctgtgtttca tgagcgctat gccctcatcc agcatcagaa gtcacacaag aatgagaagc gctttaagtg tgaccagtgt gattacgctt gtagacagga gaggcacatg atcatgcaca agcgcaccca caccggggag aagccttacg cctgcagcca ctgcgataag accttccgcc agaagcagct tctcgacatg cacttcaagc gctatcacga ccccaacttc gtccctgcgg cttttgtctg ttctaagtgt gggaaaacat ttacacgtcg gaataccatg gcaagacatg ctgataattg tgctggccca gatggcgtag agggggaaaa tggaggagaa acgaagaaga gtaaacgtgg aagaaaaaga aagatgcgct ctaagaaaga agattcctct gacagtgaaa atgctgaacc agatctggac gacaatgagg atgaggagga gcctgccgta gaaattgaac ctgagccaga gcctcagcct gtgaccccag ccccaccacc cgccaagaag cggagaggac gaccccctgg cagaaccaac cagcccaaac agaaccagcc aacagctatc attcaggttg aagaccagaa tacaggtgca attgagaaca ttatagttga agtaaaaaaa gagccagatg ctgagcccgc agagggagag gaagaggagg cccagccagc tgccacagat gcccccaacg gagacctcac gcccgagatg atcctcagca tgatggaccg gtga

Molecular Weight

45,998 Da

OMIM

604167

Vector

pENTR223.1 or pUC

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of CTCF cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CTCF. It may not necessarily be applicable to this product.

NCBI GI #

33878521

NCBI GeneID

10664

NCBI Accession #

BC014267

UniProt Secondary Accession #

Q53XI7; Q59EL8; B5MC38

UniProt Related Accession #

P49711

NCBI Official Full Name

Homo sapiens CCCTC-binding factor (zinc finger protein), mRNA

NCBI Official Synonym Full Names

CCCTC-binding factor

NCBI Official Symbol

CTCF

NCBI Official Synonym Symbols

MRD21

UniProt Protein Name

Transcriptional repressor CTCF

UniProt Synonym Protein Names

11-zinc finger protein; CCCTC-binding factor; CTCFL paralog

Protein Family

Transcriptional repressor

UniProt Gene Name

CTCF

UniProt Entry Name

CTCF_HUMAN

NCBI Protein Information

transcriptional repressor CTCF

NCBI Summary for CTCF

This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

UniProt Comments for CTCF

CTCF: a widely expressed, sequence-specific DNA-binding transcriptional regulator, insulator, and organizer of higher-order chromatin structure. Acts as a tumor suppressor. Contains 11 C2H2-type zinc fingers. Involved in promoter activation or repression, hormone-responsive gene silencing, methylation-dependent chromatin insulation, and genomic imprinting. Mediates pairing between X chromosomes and interactions between distant regulatory elements. Binds to promoters of c-myc, PLK, PIM1 and APP. A critical regulator of cell-cycle arrest and death after B cell receptor signaling in immature B cells. CTCF, together with YY1 and Tsix, form a regulated epigenetic switch for X-inactivation.

Protein type: C2H2-type zinc finger protein; Transcription factor; Tumor suppressor

Chromosomal Location of Human Ortholog: 16q21-q22.3

Cellular Component: chromosome, pericentric region; condensed chromosome; nucleolus; nucleoplasm; nucleus

Molecular Function: chromatin insulator sequence binding; protein binding; sequence-specific DNA binding; transcription corepressor activity; transcription factor activity; zinc ion binding

Biological Process: negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; nucleosome positioning; positive regulation of transcription, DNA-dependent; regulation of gene expression, epigenetic; regulation of molecular function, epigenetic

Disease: Mental Retardation, Autosomal Dominant 21

Research Articles on CTCF

1. The action of SNF2H at CTCF sites is functionally important as depletion of CTCF or SNF2H affects transcription of a common group of genes.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with CTCF cdna clone

Products by Pathway	Pathway Diagram
SIDS Susceptibility Pathways antibodies	SIDS Susceptibility Pathways Diagram
TGF-beta Receptor Signaling Pathway antibodies	TGF-beta Receptor Signaling Pathway Diagram

Diseases associated with CTCF cdna clone

Disease Name	Pubmed Publications
Carcinoma Antibodies	>32 publications with CTCF and Carcinoma
Kidney Diseases Antibodies	>26 publications with CTCF and Kidney Diseases
Abnormalities, Multiple Antibodies	>19 publications with CTCF and Abnormalities, Multiple
Congenital Abnormalities Antibodies	>17 publications with CTCF and Congenital Abnormalities
Adenocarcinoma Antibodies	>10 publications with CTCF and Adenocarcinoma
Neoplasms, Experimental Antibodies	>9 publications with CTCF and Neoplasms, Experimental
Lung Neoplasms Antibodies	>7 publications with CTCF and Lung Neoplasms
Liver Diseases Antibodies	>6 publications with CTCF and Liver Diseases
Liver Neoplasms Antibodies	>5 publications with CTCF and Liver Neoplasms
Carcinoma, Hepatocellular Antibodies	>5 publications with CTCF and Carcinoma, Hepatocellular

Organs/Tissues associated with CTCF cdna clone

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>61 publications with CTCF and Blood
Kidney Antibodies	>29 publications with CTCF and Kidney
Testis Antibodies	>28 publications with CTCF and Testis
Liver Antibodies	>27 publications with CTCF and Liver
Brain Antibodies	>27 publications with CTCF and Brain
Eye Antibodies	>21 publications with CTCF and Eye
Embryonic Tissue Antibodies	>20 publications with CTCF and Embryonic Tissue
Lung Antibodies	>13 publications with CTCF and Lung
Muscle Antibodies	>13 publications with CTCF and Muscle
Prostate Antibodies	>13 publications with CTCF and Prostate