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CTPS2 cDNA Clone – CTP Synthase II (Human)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1272505

MBS1272505 is a cDNA clone targeting CTPS2. More details

$400 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CTPS2, cDNA Clone
Full Product Name
CTPS2 cDNA Clone
Product Gene Name
CTPS2 cdna clone
Sequence
atgaagtaca tcctggtcac gggtggggtc atctcaggca ttggtaaagg gatcattgcc agcagcattg gaacgattct aaaatcatgt ggactccgag ttactgccat aaaaatcgac ccctatatta acatcgatgc tggcactttt tcaccttatg aacacggtga agtcttcgtc ttaaatgatg gtggagaagt tgatttagac cttggaaatt atgaaagatt tttggatatt aatctttata aagacaacaa tatcaccacg gggaagatat atcagcatgt gatcaataaa gagaggcgtg gtgattacct ggggaaaaca gtgcaagttg tccctcacat tactgatgct gtccaggagt gggttatgaa tcaagccaag gtgccggtgg atggtaataa ggaagagccc caaatatgcg ttattgagct gggaggcacc attggagaca tcgaaggaat gccgtttgtg gaggcgttta gacaattcca gtttaaggcg aaaagagaga atttctgtaa tatccacgtt agccttgtcc cacagctcag tgctaccgga gaacaaaaaa ccaaacccac ccaaaacagc gtccgcgcac tgaggggttt aggcctgtct ccagatctga ttgtctgccg aagttcaacg cccattgaga tggccgtgaa ggagaagatt tctatgtttt gtcacgtgaa ccctgaacag gtcatatgta tccatgatgt ttcttccaca taccgagttc ctgtgctttt agaggaacaa agcattgtga aatattttaa ggagagattg cacctgccca tcggtgattc tgcaagtaat ttgcttttta agtggagaaa tatggctgac aggtatgaaa ggttacagaa aatatgctcc atagccctgg ttggcaaata caccaagctc agagactgct acgcctctgt gttcaaagcc ctggaacact cagccctggc catcaaccac aagttgaatc tgatgtacat agactccatt gatctggaga agatcactga aaccgaggac cctgtgaaat ttcatgaagc ttggcagaag ctatgcaaag ctgatggtat tcttgtgcct ggaggctttg gaatcagagg aacattggga aaactccagg cgatttcttg ggcaaggaca aagaagattc cttttctggg agtttgtctt gggatgcaac tagcagtgat agagtttgca agaaactgcc ttaacttgaa agatgctgat tccacagagt ttaggccaaa tgccccagtt cctctggtga ttgatatgcc cgagcacaac cctggcaatt tgggaggaac aatgagactg ggaataagaa gaactgtttt caaaactgaa aattcaatat taaggaaact ttatggtgat gttcctttta tagaagaaag acacagacat cggttcgagg taaaccctaa cctgatcaaa caatttgagc agaatgactt aagttttgta ggtcaggatg ttgatggaga caggatggaa atcattgaac tggcaaatca tccttatttt gttggtgtcc agttccatcc tgagttttct tctaggccga tgaagccttc ccctccgtat ctggggctgt tacttgcagc aactgggaac ctgaatgcct acttgcaaca gggttgcaaa ctgtcttcca gtgatagata cagtgatgcc agtgatgaca gcttttcaga gccaaggata gctgagttgg aaataagctg a
Molecular Weight
65,678 Da
OMIM
300380
Vector
pENTR223.1 or pUC
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of CTPS2 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CTPS2. It may not necessarily be applicable to this product.

NCBI GI #
23271201
NCBI GeneID
56474
NCBI Accession #
BC034986
UniProt Secondary Accession #
Q9BRI0; Q9H809; Q9H8K9; B3KWM2
UniProt Related Accession #
Q9NRF8
NCBI Official Full Name
Homo sapiens CTP synthase II, mRNA
NCBI Official Synonym Full Names
CTP synthase 2
NCBI Official Symbol
CTPS2
UniProt Protein Name
CTP synthase 2
UniProt Synonym Protein Names
CTP synthetase 2; UTP--ammonia ligase 2
Protein Family
CTP synthase
UniProt Gene Name
CTPS2
UniProt Entry Name
PYRG2_HUMAN
NCBI Protein Information
CTP synthase 2

NCBI Summary for CTPS2

The protein encoded by this gene catalyzes the formation of CTP from UTP with the concomitant deamination of glutamine to glutamate. This protein is the rate-limiting enzyme in the synthesis of cytosine nucleotides, which play an important role in various metabolic processes and provide the precursors necessary for the synthesis of RNA and DNA. Cancer cells that exhibit increased cell proliferation also exhibit an increased activity of this encoded protein. Thus, this protein is an attractive target for selective chemotherapy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
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UniProt Comments for CTPS2

CTPS2: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides. Belongs to the CTP synthase family.

Protein type: EC 6.3.4.2; Nucleotide Metabolism - pyrimidine; Ligase

Chromosomal Location of Human Ortholog: Xp22

Cellular Component: cytosol

Molecular Function: CTP synthase activity; protein binding

Biological Process: nucleobase, nucleoside and nucleotide interconversion; pyrimidine nucleotide metabolic process
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Research Articles on CTPS2

1. CTPS2 was identified by genome-wide gene expression analyses as correlated with cellular sensitivity to cisplatin and carboplatin.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with CTPS2 cdna clone

 Products by Pathway  Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Nucleotides Pathway antibodies  Metabolism Of Nucleotides Pathway Diagram
 Pyrimidine Metabolism Pathway antibodies  Pyrimidine Metabolism Pathway Diagram
 Pyrimidine Metabolism Pathway antibodies  Pyrimidine Metabolism Pathway Diagram
 Pyrimidine Ribonucleotide Biosynthesis, UMP => UDP/UTP,CDP/CTP Pathway antibodies  Pyrimidine Ribonucleotide Biosynthesis, UMP => UDP/UTP,CDP/CTP Pathway Diagram
 Pyrimidine Ribonucleotide Biosynthesis, UMP => UDP/UTP,CDP/CTP Pathway antibodies  Pyrimidine Ribonucleotide Biosynthesis, UMP => UDP/UTP,CDP/CTP Pathway Diagram
 Synthesis And Interconversion Of Nucleotide Di- And Triphosphates Pathway antibodies  Synthesis And Interconversion Of Nucleotide Di- And Triphosphates Pathway Diagram
 UTP And CTP De Novo Biosynthesis Pathway antibodies  UTP And CTP De Novo Biosynthesis Pathway Diagram
 UTP And CTP Dephosphorylation I Pathway antibodies  UTP And CTP Dephosphorylation I Pathway Diagram
 UTP And CTP Dephosphorylation II Pathway antibodies  UTP And CTP Dephosphorylation II Pathway Diagram

Diseases associated with CTPS2 cdna clone

 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >1 publications with CTPS2 and Disease Models, Animal
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