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CYP17A1 cDNA Clone – Cytochrome P450, Family 17, Subfamily A, Polypeptide 1 (Human)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1277880

MBS1277880 is a cDNA clone targeting CYP17A1. More details

$400 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CYP17A1, cDNA Clone
Full Product Name
CYP17A1 cDNA Clone
Product Gene Name
Sequence
atgtgggagc tcgtggctct cttgctgctt accctagctt atttgttttg gcccaagaga aggtgccctg gtgccaagta ccccaagagc ctcctgtccc tgcccctggt gggcagcctg ccattcctcc ccagacacgg ccatatgcat aacaacttct tcaagctgca gaaaaaatat ggccccatct attcggttcg tatgggcacc aagactacag tgattgtcgg ccaccaccag ctggccaagg aggtgcttat taagaagggc aaggacttct ctgggcggcc tcaaatggca actctagaca tcgcgtccaa caaccgtaag ggtatcgcct tcgctgactc tggcgcacac tggcagctgc atcgaaggct ggcgatggcc acctttgccc tgttcaagga tggcgatcag aagctggaga agatcatttg tcaggaaatc agtacattgt gtgatatgct ggccacccac aacggacagt ccatagacat ctcctttcct gtcttcgtgg cggtaaccaa tgtcatctcc ttgatctgct tcaatacctc ctacaagaat ggggaccctg agttgaatgt catacagaat tacaatgaag gcatcataga caacctgagc aaagacagcc tggtggacct agtcccctgg ttgaagattt tccccaacaa aaccctggaa aaattaaaga gccatgttaa aatacgaaat gatctgctga ataaaatact tgaaaattac aaggagaaat tccggagtga ctctatcacc aacatgctgg acacactgat gcaagccaag atgaactcag ataatggcaa tgctggccca gatcaagact cagagctgct ttcagataac cacattctca ccaccatagg ggacatcttt ggggctggcg tggagaccac cacctctgtg gttaaatgga ccctggcctt cctgctgcac aatcctcagg tgaagaagaa gctctacgag gagattgacc agaatgtggg tttcagccgc acaccaacta tcagtgaccg taaccgtctc ctcctgctgg aggccaccat ccgagaggtg cttcgcctca ggcccgtggc ccctatgctc atcccccaca aggccaacgt tgactccagc atcggtgagt ttgctgtgga caagggcaca gaagttatca tcaatctgtg ggcgctgcat cacaatgaga aggagtggca ccagccggat cagttcatgc ctgagcgttt cttgaatcca gcggggaccc agctcatctc accgtcagta agctatttgc ccttcggagc aggacctcgc tcctgtatag gtgagatcct ggcccgccag gagctcttcc tcatcatggc ctggctgctg cagaggttcg acctggaggt gccagatgat gggcagctgc cctccctgga aggcatcccc aaggtggtct ttctgatcga ctctttcaaa gtgaagatca aggtgcgcca ggcctggagg gaagcccagg ctgagggtag cacctaa
Molecular Weight
57,371 Da
OMIM
202110
Vector
pENTR223.1
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of CYP17A1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CYP17A1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Homo sapiens cytochrome P450, family 17, subfamily A, polypeptide 1, mRNA
NCBI Official Synonym Full Names
cytochrome P450 family 17 subfamily A member 1
NCBI Official Symbol
CYP17A1
NCBI Official Synonym Symbols
CPT7; CYP17; S17AH; P450C17
UniProt Protein Name
Steroid 17-alpha-hydroxylase/17,20 lyase
UniProt Synonym Protein Names
17-alpha-hydroxyprogesterone aldolase (EC:4.1.2.30
UniProt Gene Name
CYP17A1
UniProt Synonym Gene Names
CYP17; S17AH; Cytochrome P450c17
UniProt Entry Name
CP17A_HUMAN
NCBI Protein Information
steroid 17-alpha-hydroxylase/17,20 lyase

NCBI Summary for CYP17A1

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia. [provided by RefSeq, Jul 2008]
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UniProt Comments for CYP17A1

CYP17A1: Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty. Defects in CYP17A1 are the cause of adrenal hyperplasia type 5 (AH5). AH5 is a form of congenital adrenal hyperplasia, a common recessive disease due to defective synthesis of cortisol. Congenital adrenal hyperplasia is characterized by androgen excess leading to ambiguous genitalia in affected females, rapid somatic growth during childhood in both sexes with premature closure of the epiphyses and short adult stature. Four clinical types: salt wasting (SW, the most severe type), simple virilizing (SV, less severely affected patients), with normal aldosterone biosynthesis, non-classic form or late onset (NC or LOAH), and cryptic (asymptomatic). Belongs to the cytochrome P450 family.

Protein type: Oxidoreductase; Lipid Metabolism - C21-steroid hormone; EC 1.14.99.9; EC 4.1.2.30

Chromosomal Location of Human Ortholog: 10q24.3

Cellular Component: endoplasmic reticulum membrane

Molecular Function: 17-alpha-hydroxyprogesterone aldolase activity; heme binding; oxygen binding; steroid 17-alpha-monooxygenase activity

Biological Process: androgen biosynthetic process; glucocorticoid biosynthetic process; hormone biosynthetic process; progesterone metabolic process; sex differentiation; steroid biosynthetic process; steroid metabolic process; sterol metabolic process

Disease: Adrenal Hyperplasia, Congenital, Due To 17-alpha-hydroxylase Deficiency
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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