Human DARC cDNA Clone Expression Plasmid – Cat# MBS1274402

DARC cDNA Clone – Group, Chemokine Receptor (Human)

Name: DARC cDNA Clone; Group, Chemokine Receptor; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1274402
Price: 235 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1274402

MBS1274402 is a cDNA clone targeting DARC. More details

$235 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

DARC, cDNA Clone

Full Product Name

DARC cDNA Clone

Product Gene Name

DARC cdna clone

Sequence

atggggaact gtctgcacag ggcggagctc tccccctcaa ctgagaactc aagtcagctg gacttcgaag atgtatggaa ttcttcctat ggtgtgaatg attccttccc agatggagac tatggtgcca acctggaagc agctgccccc tgccactcct gtaacctgct ggatgactct gcactgccct tcttcatcct caccagtgtc ctgggtatcc tagctagcag cactgtcctc ttcatgcttt tcagacctct cttccgctgg cagctctgcc ctggctggcc tgtcctggca cagctggctg tgggcagtgc cctcttcagc attgtggtgc ccgtcttggc cccagggcta ggtagcactc gcagctctgc cctgtgtagc ctgggctact gtgtctggta tggctcagcc tttgcccagg ctttgctgct agggtgccat gcctccctgg gccacagact gggtgcaggc caggtcccag gcctcaccct ggggctcact gtgggaattt ggggagtggc tgccctactg acactgcctg tcaccctggc cagtggtgct tctggtggac tctgcaccct gatatacagc acggagctga aggctttgca ggccacacac actgtagcct gtcttgccat ctttgtcttg ttgccattgg gtttgtttgg agccaagggg ctgaagaagg cattgggtat ggggccaggc ccctggatga acatcctgtg ggcctggttt attttctggt ggcctcatgg ggtggttcta ggactggatt tcctggtgag gtccaagctg ttgctgttgt caacatgtct ggcccagcag gctctggacc tgctgctgaa cctggcagaa gccctggcaa ttttgcactg tgtggctacg cccctgctcc tcgccctatt ctgccaccag gccacccgca ccctcttgcc ctctctgccc ctccctgaag gatggttttc tcatctggac acccttggaa gcaaatccta g

Molecular Weight

35,678 Da

OMIM

110700

Vector

pENTR223.1

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of DARC cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for DARC. It may not necessarily be applicable to this product.

NCBI GI #

17389573

NCBI GeneID

2532

NCBI Accession #

BC017817

UniProt Secondary Accession #

O75898; Q16300; Q8WWE3; Q9UJP0; Q9UKZ5; Q9UKZ6; Q9UQE1; A8YPG5

UniProt Related Accession #

Q16570

NCBI Official Full Name

Homo sapiens Duffy blood group, chemokine receptor, mRNA

NCBI Official Synonym Full Names

atypical chemokine receptor 1 (Duffy blood group)

NCBI Official Symbol

ACKR1

NCBI Official Synonym Symbols

FY; Dfy; GPD; DARC; GpFy; CCBP1; CD234; WBCQ1

UniProt Protein Name

Atypical chemokine receptor 1

UniProt Synonym Protein Names

Duffy antigen/chemokine receptor; Fy glycoprotein; GpFy; Glycoprotein D; Plasmodium vivax receptor; CD_antigen: CD234

Protein Family

Darcynin

UniProt Gene Name

ACKR1

UniProt Synonym Gene Names

DARC; FY; GPD; GpFy

UniProt Entry Name

ACKR1_HUMAN

NCBI Protein Information

atypical chemokine receptor 1

NCBI Summary for DARC

The protein encoded by this gene is a glycosylated membrane protein and a non-specific receptor for several chemokines. The encoded protein is the receptor for the human malarial parasites Plasmodium vivax and Plasmodium knowlesi. Polymorphisms in this gene are the basis of the Duffy blood group system. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

UniProt Comments for DARC

DARC: Non-specific receptor for many chemokines such as IL-8, GRO, RANTES, MCP-1 and TARC. It is also the receptor for the human malaria parasites Plasmodium vivax and Plasmodium knowlesi. Belongs to the G-protein coupled receptor Duffy family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; GPCR, Duffy family; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 1q21-q22

Cellular Component: plasma membrane

Molecular Function: C-C chemokine binding; receptor activity; transmembrane receptor activity

Biological Process: inflammatory response; regulation of chemokine production

Disease: Blood Group, Duffy System; Malaria, Susceptibility To; White Blood Cell Count Quantitative Trait Locus 1

Research Articles on DARC

1. We showed that DARC expression is down-regulated in CRC and associated with clinical pathological features and MVD of CRC. DARC might be involved in tumorigenesis, progression, angiogenesis, and metastasis of CRC.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with DARC cdna clone

Products by Pathway	Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
GPCRs, Other Pathway antibodies	GPCRs, Other Pathway Diagram
Malaria Pathway antibodies	Malaria Pathway Diagram
Malaria Pathway antibodies	Malaria Pathway Diagram
Peptide GPCRs Pathway antibodies	Peptide GPCRs Pathway Diagram
Peptide Ligand-binding Receptors Pathway antibodies	Peptide Ligand-binding Receptors Pathway Diagram
Signal Transduction Pathway antibodies	Signal Transduction Pathway Diagram
Signaling By GPCR Pathway antibodies	Signaling By GPCR Pathway Diagram

Diseases associated with DARC cdna clone

Disease Name	Pubmed Publications
Malaria Antibodies	>68 publications with DARC and Malaria
Inflammation Antibodies	>39 publications with DARC and Inflammation
Neoplasms Antibodies	>29 publications with DARC and Neoplasms
Death Antibodies	>21 publications with DARC and Death
Necrosis Antibodies	>10 publications with DARC and Necrosis
Acute Lung Injury Antibodies	>7 publications with DARC and Acute Lung Injury
Kidney Diseases Antibodies	>7 publications with DARC and Kidney Diseases
Lung Neoplasms Antibodies	>6 publications with DARC and Lung Neoplasms
Liver Diseases Antibodies	>5 publications with DARC and Liver Diseases
Hemolysis Antibodies	>4 publications with DARC and Hemolysis

Organs/Tissues associated with DARC cdna clone

Organ/Tissue Name	Pubmed Publications
Vascular Antibodies	>38 publications with DARC and Vascular
Heart Antibodies	>24 publications with DARC and Heart
Lung Antibodies	>22 publications with DARC and Lung
Kidney Antibodies	>18 publications with DARC and Kidney
Brain Antibodies	>10 publications with DARC and Brain
Eye Antibodies	>7 publications with DARC and Eye
Bone Antibodies	>5 publications with DARC and Bone
Pharynx Antibodies	>3 publications with DARC and Pharynx
Placenta Antibodies	>2 publications with DARC and Placenta
Uterus Antibodies	>1 publications with DARC and Uterus