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DEK cDNA Clone – DEK Oncogene (Human)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1267823

MBS1267823 is a cDNA clone targeting DEK. More details

$455 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
DEK, cDNA Clone
Full Product Name
DEK cDNA Clone
Product Gene Name
DEK cdna clone
Sequence
atgtccgcct cggcccctgc tgcggagggg gagggaaccc ccacccagcc cgcgtccgag aaagaacccg aaatgcccgg tcccagagag gagagcgagg aggaagagga cgaggacgac gaggaggagg aggaggagga aaaagaaaag agtctcatcg tggaaggcaa gagggaaaag aaaaaagtag agaggttgac aatgcaagtc tcttccttac agagagagcc atttacaatt gcacaaggaa aggggcagaa actttgtgaa attgagagga tacatttttt tctaagtaag aagaaaaccg atgaacttag aaatctacac aaactgcttt acaacaggcc aggcactgtg tcctcattaa agaagaatgt gggtcagttc agtggctttc catttgaaaa aggaagtgtc caatataaaa agaaggaaga aatgttgaaa aaatttagaa atgccatgtt aaagagcatc tgtgaggttc ttgatttgga gagatcaggt gtaaatagtg aactagtgaa gaggatcttg aatttcttaa tgcatccaaa gccttctggc aaaccattgc cgaaatctaa aaaaacttgt agcaaaggca gtaaaaagga acggaacagt tctggaatgg caaggaaggc taagcgaacc aaatgtcctg aaattctgtc agatgaatct agtagtgatg aagatgaaaa gaaaaacaag gaagagtctt cagatgatga agataaagaa agtgaagagg agccaccaaa aaagacagcc aaaagagaaa aacctaaaca gaaagctact tctaaaagta aaaaatctgt gaaaagtgcc aatgttaaga aagcagatag cagcaccacc aagaagaatc aaaacagttc caaaaaagaa agtgagtctg aggatagttc agatgatgaa cctttaatta aaaagttgaa gaaaccccct acagatgaag agttaaagga aacaataaag aaattactgg ccagtgctaa cttggaagaa gtcacaatga aacagatttg caaaaaggtc tatgaaaatt atcctactta tgatttaact gaaagaaaag atttcataaa aacaactgta aaagagctaa tttcttga
Molecular Weight
38,705 Da
OMIM
125264
Vector
Please Inquire
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of DEK cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for DEK. It may not necessarily be applicable to this product.

NCBI GI #
23273865
NCBI GeneID
7913
NCBI Accession #
BC035259
UniProt Secondary Accession #
Q5TGV4; Q5TGV5; B2R6K6; B4DN37
UniProt Related Accession #
P35659
NCBI Official Full Name
Homo sapiens DEK oncogene, mRNA
NCBI Official Synonym Full Names
DEK proto-oncogene
NCBI Official Symbol
DEK
NCBI Official Synonym Symbols
D6S231E
UniProt Protein Name
Protein DEK
Protein Family
Protein
UniProt Gene Name
DEK
UniProt Entry Name
DEK_HUMAN
NCBI Protein Information
protein DEK

NCBI Summary for DEK

This gene encodes a protein with one SAP domain. This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA, and is also involved in splice site selection during mRNA processing. Chromosomal aberrations involving this region, increased expression of this gene, and the presence of antibodies against this protein are all associated with various diseases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
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UniProt Comments for DEK

DEK: a ubiquitous protein with a SAP domain, which is found in a variety of nuclear proteins involved in transcription, DNA repair, RNA processing or apoptotic chromatin degradation. This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA and is also involved in splice site selection during mRNA processing. A chromosomal aberration involving DEK is found in a subset of acute myeloid leukemias (AML).

Protein type: Oncoprotein; DNA-binding; DNA replication; RNA splicing; Histone-binding

Chromosomal Location of Human Ortholog: 6p22.3

Cellular Component: nucleoplasm; nucleus

Molecular Function: histone binding

Biological Process: positive regulation of gene expression, epigenetic; regulation of transcription from RNA polymerase II promoter; signal transduction; transcription from RNA polymerase II promoter; viral genome replication
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Research Articles on DEK

1. Results find that DEK binds to transcription start sites with a dual role in activation and repression of highly and ubiquitously expressed genes.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with DEK cdna clone

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >105 publications with DEK and Neoplasms
 Adenocarcinoma Antibodies  >8 publications with DEK and Adenocarcinoma
 Cell Transformation, Neoplastic Antibodies  >6 publications with DEK and Cell Transformation, Neoplastic
 Neoplasms, Experimental Antibodies  >6 publications with DEK and Neoplasms, Experimental
 Carcinoma, Squamous Cell Antibodies  >6 publications with DEK and Carcinoma, Squamous Cell
 Carcinoma, Hepatocellular Antibodies  >5 publications with DEK and Carcinoma, Hepatocellular
 Neoplasm Metastasis Antibodies  >5 publications with DEK and Neoplasm Metastasis
 Breast Neoplasms Antibodies  >5 publications with DEK and Breast Neoplasms
 Skin Neoplasms Antibodies  >4 publications with DEK and Skin Neoplasms
 Cardiovascular Diseases Antibodies  >4 publications with DEK and Cardiovascular Diseases

Organs/Tissues associated with DEK cdna clone

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >42 publications with DEK and Blood
 Bone Antibodies  >27 publications with DEK and Bone
 Bone Marrow Antibodies  >25 publications with DEK and Bone Marrow
 Eye Antibodies  >9 publications with DEK and Eye
 Bladder Antibodies  >8 publications with DEK and Bladder
 Brain Antibodies  >8 publications with DEK and Brain
 Liver Antibodies  >7 publications with DEK and Liver
 Skin Antibodies  >7 publications with DEK and Skin
 Lung Antibodies  >5 publications with DEK and Lung
 Kidney Antibodies  >5 publications with DEK and Kidney
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