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DES cDNA Clone – Desmin (Human)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1277000

MBS1277000 is a cDNA clone targeting DES. More details

$565 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
DES, cDNA Clone
Full Product Name
DES cDNA Clone
Product Gene Name
DES cdna clone
Sequence
atgagccagg cctactcgtc cagccagcgc gtgtcctcct accgccgcac cttcggcggg gccccgggct tcccgctcgg ctccccgctg agctcgcccg tgttcccgcg ggcgggtttc ggctctaagg gctcctccag ctcggtgacg tcccgcgtgt accaggtgtc gcgcacgtcg ggcggggccg ggggcctggg gtcgctgcgg gccagccggc tggggaccac ccgcacgccc tcctcctacg gcgcaggcga gctgctggac ttctcactgg ccgacgcggt gaaccaggag tttctgacca cgcgcaccaa cgagaaggtg gagctgcagg agctcaatga ccgcttcgcc aactacatcg agaaggtgcg cttcctggag cagcagaacg cggcgctcgc cgccgaagtg aaccggctca agggccgcga gccgacgcga gtggccgagc tctacgagga ggagctgcgg gagctgcggc gccaggtgga ggtgctcact aaccagcgcg cgcgcgtcga cgtcgagcgc gacaacctgc tcgacgacct gcagcggctc aaggccaagc tgcaggagga gattcagttg aaggaagaag cagagaacaa tttggctgcc ttccgagcgg acgtggatgc agctactcta gctcgcattg acctggagcg cagaattgaa tctctcaacg aggagatcgc gttccttaag aaagtgcatg aagaggagat ccgtgagttg caggctcagc ttcaggaaca gcaggtccag gtggagatgg acatgtctaa gccagacctc actgccgccc tcagggatat ccgggctcag tatgagacca tcgcggctaa gaacatttct gaagctgagg agtggtacaa gtcgaaggtg tcagacctga cccaggcagc caacaagaac aacgacgccc tgcgccaggc caagcaggag atgatggaat accgacacca gatccagtcc tacacctgcg agattgacgc cctcaagggc actaacgatt ccctgatgag gcagatgcgg gaattggagg accgatttgc cagtgaggcc agtggctacc aggacaacat tgcacgcctg gaggaggaaa tccggcacct caaggatgag atggcccgcc atctgcgcga gtaccaggac ctgctcaacg tgaagatggc cctggatgtg gagattgcca cctaccggaa gctgctggag ggagaggaga gccggatcaa tctccccatc cagacctact ctgccctcaa tttccgagaa accagccctg agcaaagggg ttctgaggtc cataccaaga agacggtgat gatcaagacc atcgagacac gggatgggga ggtcgtcagt gaggccacac agcagcagca tgaagtgctc taa
Molecular Weight
53,536 Da
OMIM
125660
Vector
Please Inquire
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of DES cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for DES. It may not necessarily be applicable to this product.

NCBI GI #
33878070
NCBI GeneID
1674
NCBI Accession #
BC032116
UniProt Secondary Accession #
Q15787; Q549R7; Q549R8; Q549R9; Q8IZR1; Q8IZR6; Q8NES2; Q8NEU6; Q8TAC4; Q8TCX2; Q8TD99
UniProt Related Accession #
P17661
NCBI Official Full Name
Homo sapiens desmin, mRNA
NCBI Official Synonym Full Names
desmin
NCBI Official Symbol
DES
NCBI Official Synonym Symbols
CSM1; CSM2; LGMD2R
UniProt Protein Name
Desmin
Protein Family
9-divinyl ether synthase
UniProt Gene Name
DES
UniProt Entry Name
DESM_HUMAN
NCBI Protein Information
desmin

NCBI Summary for DES

This gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies. [provided by RefSeq, Jul 2008]
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UniProt Comments for DES

desmin: a class-III intermediate filaments found in muscle cells. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies.

Protein type: Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 2q35

Cellular Component: cytosol; intermediate filament cytoskeleton; sarcolemma; Z disc

Molecular Function: cytoskeletal protein binding; identical protein binding; protein binding; structural constituent of cytoskeleton

Biological Process: cytoskeleton organization and biogenesis; intermediate filament organization; muscle contraction; muscle filament sliding; regulation of heart contraction

Disease: Cardiomyopathy, Dilated, 1i; Muscular Dystrophy, Limb-girdle, Type 2r; Myopathy, Myofibrillar, 1; Scapuloperoneal Syndrome, Neurogenic, Kaeser Type
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Research Articles on DES

1. Increasing desmin abnormalities were correlated with diastolic dysfunction progression.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with DES cdna clone

 Products by Pathway  Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Aurora B Signaling Pathway antibodies  Aurora B Signaling Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Hypertrophic Cardiomyopathy (HCM) Pathway antibodies  Hypertrophic Cardiomyopathy (HCM) Pathway Diagram
 Hypertrophic Cardiomyopathy (HCM) Pathway antibodies  Hypertrophic Cardiomyopathy (HCM) Pathway Diagram
 Muscle Contraction Pathway antibodies  Muscle Contraction Pathway Diagram
 Striated Muscle Contraction Pathway antibodies  Striated Muscle Contraction Pathway Diagram

Diseases associated with DES cdna clone

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >11086 publications with DES and Neoplasms
 Nervous System Diseases Antibodies  >8283 publications with DES and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >7961 publications with DES and Cardiovascular Diseases
 Heart Diseases Antibodies  >4609 publications with DES and Heart Diseases
 Carcinoma Antibodies  >3326 publications with DES and Carcinoma
 Drug Toxicity Antibodies  >3258 publications with DES and Drug Toxicity
 Inflammation Antibodies  >2983 publications with DES and Inflammation
 Pain Antibodies  >2599 publications with DES and Pain
 Liver Diseases Antibodies  >2153 publications with DES and Liver Diseases
 Thrombosis Antibodies  >1940 publications with DES and Thrombosis

Organs/Tissues associated with DES cdna clone

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >16533 publications with DES and Blood
 Brain Antibodies  >8306 publications with DES and Brain
 Vascular Antibodies  >4948 publications with DES and Vascular
 Muscle Antibodies  >4776 publications with DES and Muscle
 Heart Antibodies  >4379 publications with DES and Heart
 Liver Antibodies  >4332 publications with DES and Liver
 Bone Antibodies  >3770 publications with DES and Bone
 Skin Antibodies  >2946 publications with DES and Skin
 Lung Antibodies  >2931 publications with DES and Lung
 Nerve Antibodies  >2585 publications with DES and Nerve
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