Human DNAJC3 cDNA Clone Expression Plasmid – Cat# MBS1266493

DNAJC3 cDNA Clone – Dnaj (Hsp40) Homolog, Subfamily C, Member 3 (Human)

Name: DNAJC3 cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1266493
Price: 235 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1266493

MBS1266493 is a cDNA clone targeting DNAJC3. More details

$235 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

DNAJC3, cDNA Clone

Full Product Name

DNAJC3 cDNA Clone

Product Gene Name

DNAJC3 cdna clone

Sequence

atggtggccc ccggctccgt gaccagccgg ctgggctcgg tattcccctt cctgctagtc ctggtggatc tgcagtacga aggtgctgaa tgtggagtaa atgcagatgt tgagaaacat cttgaattgg gcaagaaatt acttgcagct ggacagctag ctgatgcttt atctcagttt catgctgccg tagatggtga ccctgataac tatattgctt attatcggag ggctactgtc tttttagcta tgggcaaatc aaaagctgca cttcctgatt taactaaagt gattcaattg aagatggact tcactgcagc aagattacag agaggtcact tattactcaa acaaggaaaa cttgatgaag cagaagatga ttttaaaaaa gtgctcaaat ctaatccaag tgaaaatgaa gaaaaggaag cacagtctca acttataaaa tctgatgaaa tgcagcgttt gcgttcacaa gcacttaacg cttttggaag tggagattat actgctgcta tagccttcct tgataagatt ttagaggttt gtgtttggga tgcagaacta cgggaacttc gagctgaatg ttttataaaa gaaggagaac ctaggaaagc tataagtgac ttaaaagctg cgtcaaagtt gaagaatgat aatactgaag cgttttataa aataagcaca ctgtactacc aactaggaga ccacgaactg tccctcagtg aagttcggga atgtcttaaa cttgaccagg atcataaaag gtgttttgca cactataaac aagtaaagaa acttaataag ctgattgagt cagctgaaga gctcatcaga gatggcagat acacagatgc taccagcaaa tatgaatctg tcatgaaaac agagccaagc attgctgaat atacagttcg ttcaaaggag aggatttgcc actgcttttc taaggacgag aagcctgttg aagctattag ggtttgttct gaagttttac agatggaacc tgacaatgtg aatgccctga aagatcgagc agaggcctat ttgatagagg aaatgtatga tgaagctatt caggattatg aaactgctca ggaacacaat gaaaatgatc agcagattcg agaaggtcta gagaaagcac aaagattatt gaaacagtcg cagaaacgag attattataa aatcttggga gtaaaaagaa atgccaaaaa gcaagaaatt attaaagcat accgaaaatt agcactgcag tggcacccag ataacttcca gaatgaagaa gaaaagaaaa aagctgagaa aaagttcatt gatatagcag ctgctaaaga agtcctctct gatccagaaa tgagaaagaa gtttgacgac ggagaagatc ctttggatgc agagagccag caaggaggcg gcggcaaccc tttccacaga agctggaact catggcaagg gttcaatccc ttcagctcag gcggaccatt tagatttaaa ttccacttca attaa

Molecular Weight

57,580 Da

OMIM

601184

Vector

pENTR223.1

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of DNAJC3 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for DNAJC3. It may not necessarily be applicable to this product.

NCBI GI #

28839677

NCBI GeneID

5611

NCBI Accession #

BC047936

UniProt Secondary Accession #

Q86WT9; Q8N4N2

UniProt Related Accession #

Q13217

NCBI Official Full Name

Homo sapiens DnaJ (Hsp40) homolog, subfamily C, member 3, mRNA

NCBI Official Synonym Full Names

DnaJ heat shock protein family (Hsp40) member C3

NCBI Official Symbol

DNAJC3

NCBI Official Synonym Symbols

P58; HP58; ACPHD; ERdj6; PRKRI; P58IPK

UniProt Protein Name

DnaJ homolog subfamily C member 3

UniProt Synonym Protein Names

Endoplasmic reticulum DNA J domain-containing protein 6; ER-resident protein ERdj6; ERdj6; Interferon-induced, double-stranded RNA-activated protein kinase inhibitor; Protein kinase inhibitor of 58 kDa; Protein kinase inhibitor p58

Protein Family

DnaJ homolog subfamily

UniProt Gene Name

DNAJC3

UniProt Synonym Gene Names

P58IPK; PRKRI; ER-resident protein ERdj6; ERdj6; Protein kinase inhibitor p58

UniProt Entry Name

DNJC3_HUMAN

NCBI Protein Information

dnaJ homolog subfamily C member 3

NCBI Summary for DNAJC3

This gene encodes a protein with multiple tetratricopeptide repeat (TPR) motifs as well as the highly conserved J domain found in DNAJ chaperone family members. It is a member of the tetratricopeptide repeat family of proteins and acts as an inhibitor of the interferon-induced, dsRNA-activated protein kinase (PKR). [provided by RefSeq, Jul 2010]

UniProt Comments for DNAJC3

DNAJC3: Involved in the unfolded protein response (UPR) during ER stress. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity. Interacts with EIF2AK3 and EIF2AK2. Forms a trimeric complex with DNAJB1 and HSPA8. Interacts with PRKRIR/P52RIPK. Up-regulated during an endoplasmic reticulum stress via ATF6. Activated in response to infection by influenza virus through the dissociation of DNAJB1. Down-regulated by DNAJB1 and PRKRIR/P52RIPK. Widely expressed with high level in the pancreas and testis. Also expressed in cell lines with different levels.

Protein type: Endoplasmic reticulum; Inhibitor; Chaperone; Protein kinase, regulatory subunit

Chromosomal Location of Human Ortholog: 13q32.1

Cellular Component: cytoplasm; cytosol; endoplasmic reticulum; endoplasmic reticulum lumen; membrane

Molecular Function: protein kinase binding; protein kinase inhibitor activity

Biological Process: negative regulation of apoptosis

Disease: Ataxia, Combined Cerebellar And Peripheral, With Hearing Loss And Diabetes Mellitus

Research Articles on DNAJC3

1. p58IPK is a general inhibitor of the eIF2alpha kinases in that it also interacts with GCN2. Thus forced overexpression of cytoplasmic p58 delays eIF2alpha phosphorylation, suppresses GCN2 phosphorylation and prolongs protein synthesis

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with DNAJC3 cdna clone

Products by Pathway	Pathway Diagram
Activation Of Chaperone Genes By XBP1(S) Pathway antibodies	Activation Of Chaperone Genes By XBP1(S) Pathway Diagram
Activation Of Chaperones By IRE1alpha Pathway antibodies	Activation Of Chaperones By IRE1alpha Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
Influenza A Pathway antibodies	Influenza A Pathway Diagram
Influenza A Pathway antibodies	Influenza A Pathway Diagram
Influenza Infection Pathway antibodies	Influenza Infection Pathway Diagram
Influenza Life Cycle Pathway antibodies	Influenza Life Cycle Pathway Diagram
Influenza Viral RNA Transcription And Replication Pathway antibodies	Influenza Viral RNA Transcription And Replication Pathway Diagram
Metabolism Of Proteins Pathway antibodies	Metabolism Of Proteins Pathway Diagram
Protein Processing In Endoplasmic Reticulum Pathway antibodies	Protein Processing In Endoplasmic Reticulum Pathway Diagram

Diseases associated with DNAJC3 cdna clone

Disease Name	Pubmed Publications
Neoplasms Antibodies	>6 publications with DNAJC3 and Neoplasms
Nervous System Diseases Antibodies	>4 publications with DNAJC3 and Nervous System Diseases
Brain Diseases Antibodies	>3 publications with DNAJC3 and Brain Diseases
Cell Transformation, Neoplastic Antibodies	>2 publications with DNAJC3 and Cell Transformation, Neoplastic
Movement Disorders Antibodies	>2 publications with DNAJC3 and Movement Disorders
Disease Models, Animal Antibodies	>2 publications with DNAJC3 and Disease Models, Animal
Drug Toxicity Antibodies	>2 publications with DNAJC3 and Drug Toxicity
Inflammation Antibodies	>2 publications with DNAJC3 and Inflammation
Congenital Abnormalities Antibodies	>1 publications with DNAJC3 and Congenital Abnormalities
Neoplasms, Experimental Antibodies	>1 publications with DNAJC3 and Neoplasms, Experimental

Organs/Tissues associated with DNAJC3 cdna clone

Organ/Tissue Name	Pubmed Publications
Pancreas Antibodies	>5 publications with DNAJC3 and Pancreas
Vascular Antibodies	>3 publications with DNAJC3 and Vascular
Blood Antibodies	>3 publications with DNAJC3 and Blood
Muscle Antibodies	>2 publications with DNAJC3 and Muscle
Liver Antibodies	>2 publications with DNAJC3 and Liver
Intestine Antibodies	>2 publications with DNAJC3 and Intestine
Eye Antibodies	>2 publications with DNAJC3 and Eye
Brain Antibodies	>2 publications with DNAJC3 and Brain
Lung Antibodies	>2 publications with DNAJC3 and Lung
Spleen Antibodies	>1 publications with DNAJC3 and Spleen