Human DOK2 cDNA Clone Expression Plasmid – Cat# MBS1277410

DOK2 cDNA Clone – Docking Protein 2, 56kDa (Human)

Name: DOK2 cDNA Clone; Docking Protein 2, 56kDa; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1277410
Price: 235 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1277410

MBS1277410 is a cDNA clone targeting DOK2. More details

$235 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

DOK2, cDNA Clone

Full Product Name

DOK2 cDNA Clone

Product Gene Name

DOK2 cdna clone

Sequence

atgggagacg gggcagtgaa acaaggcttc ttgtatcttc agcagcagca gacgtttgga aagaaatggc gccgcttcgg cgcctcactg tatggagggt cggactgcgc cttggcccgg ctggagctgc aggagggccc ggagaagcct cgtcggtgtg aggctgcccg gaaggtcatc cgcctcagtg actgcctgcg ggtggccgag gccggcggag aggccagcag cccccgggac accagtgcct tcttcctgga gaccaaggag cgcctgtacc tcctggcggc ccctgcagcg gagcgcggcg actgggtgca ggccatctgc ctcctggcct tccccgggca gaggaaggag ctctcggggc cagagggaaa gcagagccgg ccctgcatgg aggaaaatga attgtacagc agcgcagtca cagtcggccc ccacaaggaa tttgctgtga ccatgagacc tacagaagcc agtgagaggt gccacctgcg ggggtcctat accctccggg ctggggagag tgccctggag ctgtggggtg ggcccgagcc agggacccag ctgtacgact ggccctacag gtttctgcgg cgctttgggc gggacaaggt aaccttttcc tttgaggcag gccgtcgctg cgtctctgga gagggcaact ttgagttcga aacccggcaa ggcaatgaga tcttcttggc cctggaagag gccatctctg cccagaagaa tgctgcaccc gctacacccc aaccgcagcc agccacaatc cccgcctcgc tgccccggcc tgatagcccc tactctcggc cgcatgactc actgccgccg ccttcaccca ccacaccggt gcctgctcca cggcctcggg gccaggaggg ggagtatgcc gtgcccttcg atgcggtggc ccgttccttg gggaagaact tcaggggcat cttggcagtc cctcctcagc tcctggccga ccctctgtac gacagcattg aggagaccct gccccctcga cctgaccaca tatacgatga gcccgaggga gtggctgccc tgtccctcta tgacagcccg caggagcccc ggggtgaggc atggaggagg caggcgacag ctgacaggga ccctgctggc ctccagcatg tccagccagc tgggcaggat ttctctgctt ctggctggca gccaggaact gagtatgaca atgttgtact aaagaaaggc ccaaagtga

Molecular Weight

45,379 Da

OMIM

604997

Vector

pENTR223.1 or pUC

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of DOK2 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for DOK2. It may not necessarily be applicable to this product.

NCBI GI #

21618482

NCBI GeneID

9046

NCBI Accession #

BC032623

UniProt Secondary Accession #

Q8N5A4

UniProt Related Accession #

O60496

NCBI Official Full Name

Homo sapiens docking protein 2, 56kDa, mRNA

NCBI Official Synonym Full Names

docking protein 2

NCBI Official Symbol

DOK2

NCBI Official Synonym Symbols

p56DOK; p56dok-2

UniProt Protein Name

Docking protein 2

UniProt Synonym Protein Names

Downstream of tyrosine kinase 2; p56(dok-2)

Protein Family

Docking protein

UniProt Gene Name

DOK2

UniProt Entry Name

DOK2_HUMAN

NCBI Protein Information

docking protein 2

NCBI Summary for DOK2

The protein encoded by this gene is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells. [provided by RefSeq, Jul 2008]

UniProt Comments for DOK2

DOK2: a member of the p62dok family of proteins that interact with receptor tyrosine kinases and mediate particular biological responses. Constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/Abl), a chimeric protein whose presence is associated with CML. Contains a pleckstrin homology domain at the amino terminus, 13 potential tyrosine phosphorylation sites, and six PXXP SH3 recognition motifs. Binds p120 (RasGAP) from CML cells.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 8p21.3

Cellular Component: cytosol

Molecular Function: protein binding

Biological Process: cell surface receptor linked signal transduction; leukocyte migration; signal transduction

Research Articles on DOK2

1. point mutations in DOK1 and DOK2 genes are detected with low frequency in chronic myelomonocytic leukemia but may have consequences for the function of the DOK2 PTB domain

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with DOK2 cdna clone

Products by Pathway	Pathway Diagram
Angiopoietin Receptor Tie2-mediated Signaling Pathway antibodies	Angiopoietin Receptor Tie2-mediated Signaling Pathway Diagram
Cell Surface Interactions At The Vascular Wall Pathway antibodies	Cell Surface Interactions At The Vascular Wall Pathway Diagram
EGFR1 Signaling Pathway antibodies	EGFR1 Signaling Pathway Diagram
Hemostasis Pathway antibodies	Hemostasis Pathway Diagram
IL-4 Signaling Pathway antibodies	IL-4 Signaling Pathway Diagram
IL2-mediated Signaling Events Pathway antibodies	IL2-mediated Signaling Events Pathway Diagram
IL4-mediated Signaling Events Pathway antibodies	IL4-mediated Signaling Events Pathway Diagram
Tie2 Signaling Pathway antibodies	Tie2 Signaling Pathway Diagram

Diseases associated with DOK2 cdna clone

Disease Name	Pubmed Publications
Neoplasms Antibodies	>16 publications with DOK2 and Neoplasms
Necrosis Antibodies	>3 publications with DOK2 and Necrosis
Adenocarcinoma Antibodies	>3 publications with DOK2 and Adenocarcinoma
Liver Diseases Antibodies	>3 publications with DOK2 and Liver Diseases
Lung Neoplasms Antibodies	>3 publications with DOK2 and Lung Neoplasms
Liver Neoplasms Antibodies	>2 publications with DOK2 and Liver Neoplasms
Inflammation Antibodies	>2 publications with DOK2 and Inflammation
Disease Models, Animal Antibodies	>2 publications with DOK2 and Disease Models, Animal
Hyperplasia Antibodies	>2 publications with DOK2 and Hyperplasia
Brain Diseases Antibodies	>1 publications with DOK2 and Brain Diseases

Organs/Tissues associated with DOK2 cdna clone

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>15 publications with DOK2 and Blood
Bone Antibodies	>9 publications with DOK2 and Bone
Lung Antibodies	>7 publications with DOK2 and Lung
Liver Antibodies	>3 publications with DOK2 and Liver
Kidney Antibodies	>2 publications with DOK2 and Kidney
Spleen Antibodies	>2 publications with DOK2 and Spleen
Stomach Antibodies	>2 publications with DOK2 and Stomach
Brain Antibodies	>2 publications with DOK2 and Brain
Thymus Antibodies	>2 publications with DOK2 and Thymus
Intestine Antibodies	>1 publications with DOK2 and Intestine