Human DPYS cDNA Clone Expression Plasmid – Cat# MBS1274023

DPYS cDNA Clone – Dihydropyrimidinase (Human)

Name: DPYS cDNA Clone; Dihydropyrimidinase; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1274023
Price: 605 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1274023

MBS1274023 is a cDNA clone targeting DPYS. More details

$605 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

DPYS, cDNA Clone

Full Product Name

DPYS cDNA Clone

Product Gene Name

DPYS cdna clone

Sequence

atggcggcgc cctcgcggct cctgatccgc gggggtcgcg tggtcaacga tgacttctcg gaggtggccg acgtgctggt ggaggacggc gtggtgcggg cactcgggca cgacctgctg cctcccgggg gcgctcctgc ggggctgcgg gtcctcgacg ccgccggcaa gctcgtcctg cccggaggca tcgacacaca cacgcacatg cagttcccct tcatgggctc gcggtccatc gacgacttcc accagggcac caaggctgct ctctcaggag gcaccaccat gattattgat ttcgccattc ctcagaaagg tggctccctc attgaggcct tcgagacctg gcgaagctgg gctgatccca aagtttgctg cgactacagc cttcatgtgg cagtgacgtg gtggagtgac caggttaaag aagaaatgaa aatccttgtg caagataaag gtgttaactc tttcaagatg tttatggcct ataaagatct gtacatggtg acagacctgg agctgtacga agccttctct cggtgcaagg aaattggagc aattgcccag gtccatgcgg aaaatggaga cttaattgca gagggagcaa agaagatgtt ggctctgggg ataacaggcc ctgagggcca cgagctgtgc cgcccagagg cagtggaggc agaggccacg ctgagagcca tcaccatagc cagcgctgtg aactgtcctc tctacattgt gcatgtgatg agcaagtctg cagctaaggt gatagcggat gcaaggagag atgggaaggt ggtctatggt gaacccatag cagccagtct tggcacagat ggcactcact actggaataa agaatggcac catgcagccc accatgtcat gggtccacct ttgcgaccag acccctcaac acccgacttc ctcatgaatc tgttggctaa tgatgatcta accacaacag ggactgataa ctgcactttc aacacctgcc agaaagctct tgggaaggat gattttacca agatccccaa tggggtgaat ggtgttgaag atcggatgtc cgtaatatgg gaaaaaggcg tgcatagtgg taaaatggat gaaaacagat ttgtggcagt taccagcaca aatgcagcca aaatttttaa tctctatcca agaaaaggaa gaatagctgt aggatcagat gctgacattg ttatttggga cccaaaaggc acaaggacta tctcagcaaa aactcatcat caggctgtta acttcaacat tttcgagggc atggtttgcc acggggtgcc ccttgtgact atttcaagag gcaaagtggt atatgaagcc ggagtgttca gtgtcacggc aggagatggg aagtttattc ctcgaaaacc atttgctgaa tatatttaca aacgaataaa gcagcgagac cggacttgca cacctacccc tgtggagcgt gcaccctata agggagaagt cgccacactg aaatccagag tgacaaaaga agatgccaca gcagggacca ggaaacaggc ccacccctga

Molecular Weight

56,630 Da

OMIM

222748

Vector

Please Inquire

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of DPYS cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for DPYS. It may not necessarily be applicable to this product.

NCBI GI #

21707926

NCBI GeneID

1807

NCBI Accession #

BC034395

UniProt Related Accession #

Q14117

NCBI Official Full Name

Homo sapiens dihydropyrimidinase, mRNA

NCBI Official Synonym Full Names

dihydropyrimidinase

NCBI Official Symbol

DPYS

NCBI Official Synonym Symbols

DHP; DHPase

UniProt Protein Name

Dihydropyrimidinase

UniProt Synonym Protein Names

Dihydropyrimidine amidohydrolase; Hydantoinase

UniProt Gene Name

DPYS

UniProt Synonym Gene Names

DHP; DHPase

UniProt Entry Name

DPYS_HUMAN

NCBI Protein Information

dihydropyrimidinase

NCBI Summary for DPYS

Dihydropyrimidinase catalyzes the conversion of 5,6-dihydrouracil to 3-ureidopropionate in pyrimidine metabolism. Dihydropyrimidinase is expressed at a high level in liver and kidney as a major 2.5-kb transcript and a minor 3.8-kb transcript. Defects in the DPYS gene are linked to dihydropyrimidinuria. [provided by RefSeq, Jul 2008]

UniProt Comments for DPYS

DPYS: Catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines. Can catalyze the ring opening of 5,6- dihydrouracil to N-carbamyl-alanine and of 5,6-dihydrothymine to N-carbamyl-amino isobutyrate. Defects in DPYS are the cause of dihydropyrimidinase deficiency (DHPD). DHPD is an autosomal recessive disorder characterized by dihydropyrimidinuria and associated with a variable clinical phenotype: epileptic or convulsive attacks, dysmorphic features and severe developmental delay, and congenital microvillous atrophy. Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily.

Protein type: Xenobiotic Metabolism - drug metabolism - other enzymes; Hydrolase; Cofactor and Vitamin Metabolism - pantothenate and CoA biosynthesis; Other Amino Acids Metabolism - beta-alanine; EC 3.5.2.2; Nucleotide Metabolism - pyrimidine

Chromosomal Location of Human Ortholog: 8q22

Cellular Component: cytosol

Molecular Function: dihydropyrimidinase activity

Biological Process: protein homotetramerization; pyrimidine base catabolic process; pyrimidine nucleoside catabolic process; thymine catabolic process; uracil catabolic process

Disease: Dihydropyrimidinase Deficiency

Research Articles on DPYS

1. Stepwise Cox regression modelling suggested that the methylation of genes HSPB1, CCND2 and DPYS contributed objective prognostic information to Gleason score and PSA with respect to prostate cancer-related death.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with DPYS cdna clone

Products by Pathway	Pathway Diagram
Drug Metabolism - Other Enzymes Pathway antibodies	Drug Metabolism - Other Enzymes Pathway Diagram
Drug Metabolism - Other Enzymes Pathway antibodies	Drug Metabolism - Other Enzymes Pathway Diagram
Fluoropyrimidine Activity Pathway antibodies	Fluoropyrimidine Activity Pathway Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Metabolism Of Nucleotides Pathway antibodies	Metabolism Of Nucleotides Pathway Diagram
Pantothenate And CoA Biosynthesis Pathway antibodies	Pantothenate And CoA Biosynthesis Pathway Diagram
Pantothenate And CoA Biosynthesis Pathway antibodies	Pantothenate And CoA Biosynthesis Pathway Diagram
Pyrimidine Catabolism Pathway antibodies	Pyrimidine Catabolism Pathway Diagram
Pyrimidine Degradation, Uracil => Beta-alanine, Thymine => 3-aminoisobutanoate Pathway antibodies	Pyrimidine Degradation, Uracil => Beta-alanine, Thymine => 3-aminoisobutanoate Pathway Diagram
Pyrimidine Degradation, Uracil => Beta-alanine, Thymine => 3-aminoisobutanoate Pathway antibodies	Pyrimidine Degradation, Uracil => Beta-alanine, Thymine => 3-aminoisobutanoate Pathway Diagram

Diseases associated with DPYS cdna clone

Disease Name	Pubmed Publications
Dihydropyrimidinase Deficiency Antibodies	>5 publications with DPYS and Dihydropyrimidinase Deficiency
Intestinal Neoplasms Antibodies	>3 publications with DPYS and Intestinal Neoplasms
Drug Toxicity Antibodies	>2 publications with DPYS and Drug Toxicity
Poisoning Antibodies	>1 publications with DPYS and Poisoning
Neoplasms, Experimental Antibodies	>1 publications with DPYS and Neoplasms, Experimental
Hyperplasia Antibodies	>1 publications with DPYS and Hyperplasia
Liver Diseases Antibodies	>1 publications with DPYS and Liver Diseases
Necrosis Antibodies	>1 publications with DPYS and Necrosis

Organs/Tissues associated with DPYS cdna clone

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>1 publications with DPYS and Brain
Liver Antibodies	>1 publications with DPYS and Liver